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Mavs
Gene Detail
 Symbol
Name
ID
Mavs
mitochondrial antiviral signaling protein
MGI:2444773
Synonyms D430028G21Rik, IPS-1
Feature Type protein coding gene
Genetic Map
Chromosome 2
63.30 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr2:131234063-131248025 bp, + strand
From VEGA annotation of GRCm38

  13963 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:17004  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Mavs

Human
homologs
Human Homolog MAVS, mitochondrial antiviral signaling protein
NCBI Gene ID 57506
neXtProt AC  NX_Q7Z434
Human Synonyms  CARDIF, IPS1, IPS-1, VISA
Human Chr (Location)  20p13; chr20:3846799-3876123 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(13) : Gene trapped(6) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous and heterozygous mice for mutations display defective innate immunity in response to viral infections.
 
Interactions
Mavs interacts with 184 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (45 annotations)
Process activation of innate immune response, cellular response to exogenous dsRNA, ...
Component cytoplasm, integral component of membrane, ...
Function CARD domain binding, protein binding, ...
External Resources: FuncBase
Expression
cDNA source data(74)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(74) cDNA(74)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000016041 (Evidence)
Ensembl Gene ModelENSMUSG00000037523 (Evidence)
Entrez Gene228607 (Evidence)
UniGene287226
DFCITC1575188, TC1618474
DoTSDT.101409883, DT.489957, DT.94375246, DT.94400877, DT.97346673
NIA Mouse Gene IndexU002492
PDB4GHU
Consensus CDS ProjectCCDS16760.1
International Mouse Knockout Project StatusMavs
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016041 VEGA Gene Model | MGI Sequence Detail 13963 C57BL/6J ±  kb
transcript OTTMUST00000038266 VEGA | MGI Sequence Detail 2867 Not Applicable 
polypeptide OTTMUSP00000017159 VEGA | MGI Sequence Detail 503 Not Applicable 

For the selected sequences
All sequences(59) RefSeq(8) UniProt(3)
Polymorphisms SNPs within 2kb(137 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR026148 Mitochondrial antiviral-signaling protein
Protein Ontology PR:000010210 mitochondrial antiviral-signaling protein
References (Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:211677 Fleige H, et al., IL-17-induced CXCL12 recruits B cells and induces follicle formation in BALT in the absence of differentiated FDCs. J Exp Med. 2014 Apr 7;211(4):643-51
All references(107)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory