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Mavs
Gene Detail
Symbol

Name
ID
Mavs
mitochondrial antiviral signaling protein
MGI:2444773
Synonyms
D430028G21Rik, IPS-1
Feature Type
protein coding gene
Genetic Map
Chromosome 2
63.30 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr2:131234063-131248025 bp, + strand
From VEGA annotation of GRCm38

  13963 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:17004  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: MAVS
Gene Tree: Mavs

Human
homologs
MAVS, mitochondrial antiviral signaling protein
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 57506
neXtProt AC: NX_Q7Z434

Human Synonyms: CARDIF, IPS1, IPS-1, VISA

Human Chr (Location): 20p13; chr20:3846799-3876123 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(13) : Gene trapped(6) Targeted(7)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous and heterozygous mice for mutations display defective innate immunity in response to viral infections.
 
Interactions
Mavs interacts with 183 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (45 annotations)
Process activation of innate immune response, cellular response to exogenous dsRNA, ...
Component cytoplasm, integral component of membrane, ...
Function CARD domain binding, protein binding, ...
External Resources: FuncBase
Expression
cDNA source data(74)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: ZFIN mavs    NEW 
Molecular
reagents
All nucleic(74) cDNA(74)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000016041 (Evidence)
Ensembl Gene Model ENSMUSG00000037523 (Evidence)
Entrez Gene 228607 (Evidence)
UniGene 287226
DFCI TC1575188, TC1618474
DoTS DT.101409883, DT.489957, DT.94375246, DT.94400877, DT.97346673
NIA Mouse Gene Index U002492
PDB 4GHU
Consensus CDS Project CCDS16760.1
International Mouse Phenotyping Consortium Status Mavs
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016041 VEGA Gene Model | MGI Sequence Detail 13963 C57BL/6J ±  kb
transcript OTTMUST00000038268 VEGA | MGI Sequence Detail 3057 Not Applicable 
polypeptide OTTMUSP00000017160 VEGA | MGI Sequence Detail 503 Not Applicable 

For the selected sequences
All sequences(59) RefSeq(8) UniProt(3)
Polymorphisms
SNPs within 2kb(137 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR026148 Mitochondrial antiviral-signalling protein
Protein Ontology PR:000010210 mitochondrial antiviral-signaling protein
References
(Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:222697 Goritzka M, et al., Alveolar macrophage-derived type I interferons orchestrate innate immunity to RSV through recruitment of antiviral monocytes. J Exp Med. 2015 May 4;212(5):699-714
All references(115)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory