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Mavs Gene Detail
Summary
  • Symbol
    Mavs
  • Name
    mitochondrial antiviral signaling protein
  • Synonyms
    D430028G21Rik, IPS-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2444773
    NCBI Gene: 228607
  • Gene Overview
    MyGene.info: MAVS
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:131234063-131248025 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 63.30 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    137 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2444773
protein coding gene Chr2:131234063-131248025 (.)
129S1/SvImJ MGP_129S1SvImJ_G0026528
protein coding gene Chr2:134750090-134763990 (+)
A/J MGP_AJ_G0026492
protein coding gene Chr2:129281041-129294971 (+)
AKR/J MGP_AKRJ_G0026467
protein coding gene Chr2:133013180-133027114 (+)
BALB/cJ MGP_BALBcJ_G0026504
protein coding gene Chr2:129667302-129682969 (+)
C3H/HeJ MGP_C3HHeJ_G0026247
protein coding gene Chr2:133451878-133465766 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026949
protein coding gene Chr2:138886815-138900723 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024326
protein coding gene Chr2:124022444-124036455 (+)
CAST/EiJ MGP_CASTEiJ_G0025708
protein coding gene Chr2:133733257-133747030 (+)
CBA/J MGP_CBAJ_G0026227
protein coding gene Chr2:144059874-144073777 (+)
DBA/2J MGP_DBA2J_G0026361
protein coding gene Chr2:128670596-128684472 (+)
FVB/NJ MGP_FVBNJ_G0026325
protein coding gene Chr2:127300591-127314579 (+)
LP/J MGP_LPJ_G0026466
protein coding gene Chr2:134981071-134994929 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026345
protein coding gene Chr2:147879412-147894395 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027004
protein coding gene Chr2:132979878-132993765 (+)
PWK/PhJ MGP_PWKPhJ_G0025444
protein coding gene Chr2:128245594-128259820 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025246
protein coding gene Chr2:132127811-132143693 (+)
WSB/EiJ MGP_WSBEiJ_G0025782
protein coding gene Chr2:133893953-133907888 (+)



Homology
more
  • Human Ortholog
    MAVS, mitochondrial antiviral signaling protein
  • Vertebrate Orthologs
    7
  • Human Ortholog
    MAVS, mitochondrial antiviral signaling protein
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CARDIF, IPS1, IPS-1, VISA
  • Links
    NCBI Gene ID: 57506
    neXtProt AC: NX_Q7Z434
    UniProt: Q7Z434

  • Chr Location
    20p13; chr20:3846799-3876123 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    38 phenotypes from 4 alleles in 6 genetic backgrounds
    27 phenotypes from multigenic genotypes
    129 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous and heterozygous mice for mutations display defective innate immunity in response to viral infections.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 228607 NCBI Gene Model | MGI Sequence Detail 13963 C57BL/6J ±  kb
transcript NM_144888 RefSeq | MGI Sequence Detail 3099 C57BL/6  
polypeptide Q8VCF0 UniProt | EBI | MGI Sequence Detail 503 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 76
    cDNA 76

    Microarray probesets 4
References
more
  • Summaries
    All 179
    Gene Ontology 11
    Phenotypes 129
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:266385 Plantamura E, et al., MAVS deficiency induces gut dysbiotic microbiota conferring a proallergic phenotype. Proc Natl Acad Sci U S A. 2018 Oct 9;115(41):10404-10409

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory