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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Mavs
mitochondrial antiviral signaling protein
MGI:2444773
29 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Ddx60tm1b(EUCOMM)Wtsi/Ddx60tm1b(EUCOMM)Wtsi
Mavstm1Tsse/Mavstm1Tsse
involves: 129 * C57BL/6N 		increased susceptibility to Riboviria infection induced morbidity/mortality J:228452
Ifih1Rgsc422/Ifih1+
Mavstm1Aki/Mavs+
involves: C57BL/6JJcl * DBA/2JJcl 		glomerulonephritis J:209917
Ifih1Rgsc422/Ifih1+
Mavstm1Aki/Mavstm1Aki
involves: C57BL/6JJcl * DBA/2JJcl 		normal immune system phenotype J:209917
Mavstm1Aki/Mavstm1Aki
Ifna6tm1Aki/Ifna6+
involves: 129P2/OlaHsd 		abnormal alveolar macrophage morphology J:124340
abnormal macrophage morphology J:124340
abnormal myeloid dendritic cell morphology J:124340
decreased interferon-alpha secretion J:124340
Mavstm1Aki/Mavstm1Aki
Ticam1tm1Aki/Ticam1tm1Aki
involves: 129P2/OlaHsd * C57BL/6 		decreased CD8-positive, alpha-beta T cell number J:130954
decreased circulating interferon-alpha level J:130954
decreased circulating interferon-beta level J:130954
decreased circulating interferon-gamma level J:130954
decreased circulating interleukin-6 level J:130954
decreased circulating interleukin-12b level J:130954
decreased cytotoxic T cell cytolysis J:130954
decreased IgG1 level J:130954
decreased IgG2a level J:130954
decreased IgG level J:130954
decreased interferon-beta secretion J:130954
decreased interleukin-12b secretion J:130954
Mavstm1Itl/Mavstm1Itl
Trex1tm1Tld/Trex1tm1Tld
involves: 129P2/OlaHsd * C57BL/6 		increased inflammatory response J:181257
myocarditis J:181257
myositis J:181257
premature death J:181257
skin inflammation J:181257
stomach inflammation J:181257
Mavstm1Tsse/Mavstm1Tsse
Tg(PVR)1Kkst/0
involves: 129 * C57BL/6 * ICR 		abnormal interferon-alpha secretion J:179625
decreased susceptibility to Picornaviridae infection induced morbidity/mortality J:179625
Mavstm1Zjc/Mavstm1Zjc
Rnaseh2atm1Crh/Rnaseh2atm1Crh
Not Specified 		abnormal innate immunity J:232933
perinatal lethality, complete penetrance J:232933
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory