Mavs^tm1Aki
Targeted Allele Detail

Summary

• Symbol: Mavs^tm1Aki
• Name: mitochondrial antiviral signaling protein; targeted mutation 1, Shizuo Akira
• MGI ID: MGI:3773161
• Synonyms: IPS-1^-
• Gene: Mavs Location: Chr2:131075983-131089945 bp, + strand Genetic Position: Chr2, 63.3 cM
• Alliance: Mavs^tm1Aki page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:124405
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1 and 2 were replaced with a neo cassette. The absence of protein expression was confirmed by western blot analysis on mouse embryonic fibroblasts. (J:124405)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mavs Mutation: 36 strains or lines available

References

• Original: J:124405 Kumar H, et al., Essential role of IPS-1 in innate immune responses against RNA viruses. J Exp Med. 2006 Jul 10;203(7):1795-803
• All: 67 reference(s)