Rnaseh2atm1Crh
Targeted Allele Detail
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Symbol: |
Rnaseh2atm1Crh |
Name: |
ribonuclease H2, large subunit; targeted mutation 1, Robert J Crouch |
MGI ID: |
MGI:6147721 |
Synonyms: |
Rnaseh2aG37S |
Gene: |
Rnaseh2a Location: Chr8:85683239-85694498 bp, - strand Genetic Position: Chr8, 41.38 cM, cytoband C3
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Alliance: |
Rnaseh2atm1Crh page
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Germline Transmission: |
Earliest citation of germline transmission:
J:232933
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
C57BL/6N
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Allele Type: |
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Targeted (Humanized sequence) |
Mutations: |
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Insertion, Nucleotide substitutions
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Mutation details: A serine substitution for glycine 37 (G37S) near the catalytic center on the RNase H2A subunit, a mutation associated with the human Aicardi-Goutieres syndrome, was introduced into this highly conserved residue of the catalytic subunit. A floxed selection cassette is present.
(J:232933)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Rnaseh2a Mutation: |
45 strains or lines available
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Original: |
J:232933 Pokatayev V, et al., RNase H2 catalytic core Aicardi-Goutieres syndrome-related mutant invokes cGAS-STING innate immune-sensing pathway in mice. J Exp Med. 2016 Mar 7;213(3):329-36 |
All: |
1 reference(s) |
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