Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rnaseh2atm1Crh mutation
(0 available);
any
Rnaseh2a mutation
(45 available)
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mortality/aging
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• mice are born dead or die within hours after birth indicating perinatal lethality
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growth/size/body
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• embryos are approximately 20% smaller from E10.5
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• approximately 20% smaller
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embryo
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• embryos are approximately 20% smaller from E10.5
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immune system
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• mice show increased expression of interferon-stimulated genes indicating innate immune activation of IFN-stimulated genes
• however, no inflammation is seen in various tissues, including the brain
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• mouse embryo fibroblasts are highly refractory to vesicular stomatitis virus infection
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nervous system
N |
• no abnormalities are seen in the brain
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rnaseh2atm1Crh mutation
(0 available);
any
Rnaseh2a mutation
(45 available)
Sting1tm1Gnb mutation
(0 available);
any
Sting1 mutation
(49 available)
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mortality/aging
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• mice are either perinatal lethal or survive after birth; survival is at 6% of expected frequency with 2% of pups surviving weaning
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growth/size/body
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• surviving mice are about 70% in body size and weight compared to controls
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• surviving mice are about 70% in body size and weight compared to controls
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pigmentation
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• white patches show lack of melanin in hair shafts
• however, skin histology from white patches in normal
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• all viable mice present a ventral white spotting phenotype and white hind- and forepaws from birth which remains through life
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cellular
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• E13.5 and E15.5 embryos exhibit increased LINE-1 retroelement DNA levels in cytosolic extract, however, no elevation in L1 ORF1 protein is seen
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integument
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• white patches show lack of melanin in hair shafts
• however, skin histology from white patches in normal
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• all viable mice present a ventral white spotting phenotype and white hind- and forepaws from birth which remains through life
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reproductive system
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• mice fail to produce offspring
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immune system
N |
• no abnormalities or inflammation in internal organs, including the brain, are seen in viable mice and expression of interferon-stimulated genes is restored to normal levels
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rag2tm1Fwa mutation
(48 available);
any
Rag2 mutation
(117 available)
Rnaseh2atm1Crh mutation
(0 available);
any
Rnaseh2a mutation
(45 available)
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cgastm1a(EUCOMM)Hmgu mutation
(1 available);
any
Cgas mutation
(23 available)
Rnaseh2atm1Crh mutation
(0 available);
any
Rnaseh2a mutation
(45 available)
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immune system
N |
• expression of interferon-stimulated genes is restored to normal levels
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mavstm1Zjc mutation
(1 available);
any
Mavs mutation
(36 available)
Rnaseh2atm1Crh mutation
(0 available);
any
Rnaseh2a mutation
(45 available)
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mortality/aging
immune system
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• E14.5 mouse embryo fibroblasts show increased expression of interferon-stimulated genes indicating innate immune activation of IFN-stimulated genes
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