All Phenotypes Rnaseh2a<tm1Crh> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Rnaseh2a^tm1Crh
targeted mutation 1, Robert J Crouch
MGI:6147721

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rnaseh2a^tm1Crh/Rnaseh2a^tm1Crh	Not Specified	MGI:6274936
cx2	Rnaseh2a^tm1Crh/Rnaseh2a^tm1Crh Sting1^tm1Gnb/Sting1^tm1Gnb	involves: 129P2/OlaHsd	MGI:6274938
cx3	Rag2^tm1Fwa/Rag2^tm1Fwa Rnaseh2a^tm1Crh/Rnaseh2a^tm1Crh	involves: 129S/SvEv	MGI:6274937
cx4	Cgas^{tm1a(EUCOMM)Hmgu}/Cgas^{tm1a(EUCOMM)Hmgu} Rnaseh2a^tm1Crh/Rnaseh2a^tm1Crh	involves: C57BL/6N	MGI:6274941
cx5	Mavs^tm1Zjc/Mavs^tm1Zjc Rnaseh2a^tm1Crh/Rnaseh2a^tm1Crh	Not Specified	MGI:6274939

Allelic Composition	Rnaseh2a^tm1Crh/Rnaseh2a^tm1Crh
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rnaseh2a^tm1Crh mutation (0 available); any Rnaseh2a mutation (44 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:232933 )

• mice are born dead or die within hours after birth indicating perinatal lethality

growth/size/body

decreased embryo size ( J:232933 )

• embryos are approximately 20% smaller from E10.5

decreased fetal size ( J:232933 )

• approximately 20% smaller

embryo

decreased embryo size ( J:232933 )

• embryos are approximately 20% smaller from E10.5

immune system

abnormal innate immunity ( J:232933 )

• mice show increased expression of interferon-stimulated genes indicating innate immune activation of IFN-stimulated genes

• however, no inflammation is seen in various tissues, including the brain

decreased susceptibility to Riboviria infection ( J:232933 )

• mouse embryo fibroblasts are highly refractory to vesicular stomatitis virus infection

nervous system

nervous system phenotype ( J:232933 )

N	• no abnormalities are seen in the brain

Allelic Composition	Rnaseh2a^tm1Crh/Rnaseh2a^tm1Crh Sting1^tm1Gnb/Sting1^tm1Gnb
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rnaseh2a^tm1Crh mutation (0 available); any Rnaseh2a mutation (44 available)
Sting1^tm1Gnb mutation (0 available); any Sting1 mutation (45 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality, incomplete penetrance ( J:232933 )

• mice are either perinatal lethal or survive after birth; survival is at 6% of expected frequency with 2% of pups surviving weaning

growth/size/body

decreased body size ( J:232933 )

• surviving mice are about 70% in body size and weight compared to controls

decreased body weight ( J:232933 )

• surviving mice are about 70% in body size and weight compared to controls

pigmentation

abnormal hair shaft melanin granule morphology ( J:232933 )

• white patches show lack of melanin in hair shafts

• however, skin histology from white patches in normal

white spotting ( J:232933 )

• all viable mice present a ventral white spotting phenotype and white hind- and forepaws from birth which remains through life

cellular

abnormal cell physiology ( J:232933 )

• E13.5 and E15.5 embryos exhibit increased LINE-1 retroelement DNA levels in cytosolic extract, however, no elevation in L1 ORF1 protein is seen

integument

abnormal hair shaft melanin granule morphology ( J:232933 )

• white patches show lack of melanin in hair shafts

• however, skin histology from white patches in normal

white spotting ( J:232933 )

• all viable mice present a ventral white spotting phenotype and white hind- and forepaws from birth which remains through life

reproductive system

infertility ( J:232933 )

• mice fail to produce offspring

immune system

immune system phenotype ( J:232933 )

N	• no abnormalities or inflammation in internal organs, including the brain, are seen in viable mice and expression of interferon-stimulated genes is restored to normal levels

Allelic Composition	Rag2^tm1Fwa/Rag2^tm1Fwa Rnaseh2a^tm1Crh/Rnaseh2a^tm1Crh
Genetic Background	involves: 129S/SvEv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rag2^tm1Fwa mutation (45 available); any Rag2 mutation (115 available)
Rnaseh2a^tm1Crh mutation (0 available); any Rnaseh2a mutation (44 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:232933 )

Allelic Composition	Cgas^{tm1a(EUCOMM)Hmgu}/Cgas^{tm1a(EUCOMM)Hmgu} Rnaseh2a^tm1Crh/Rnaseh2a^tm1Crh
Genetic Background	involves: C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cgas^{tm1a(EUCOMM)Hmgu} mutation (1 available); any Cgas mutation (26 available)
Rnaseh2a^tm1Crh mutation (0 available); any Rnaseh2a mutation (44 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:232933 )

N	• expression of interferon-stimulated genes is restored to normal levels

Allelic Composition	Mavs^tm1Zjc/Mavs^tm1Zjc Rnaseh2a^tm1Crh/Rnaseh2a^tm1Crh
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mavs^tm1Zjc mutation (1 available); any Mavs mutation (38 available)
Rnaseh2a^tm1Crh mutation (0 available); any Rnaseh2a mutation (44 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:232933 )

immune system

abnormal innate immunity ( J:232933 )

• E14.5 mouse embryo fibroblasts show increased expression of interferon-stimulated genes indicating innate immune activation of IFN-stimulated genes

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