Tmem117 Gene Detail

Summary

• Symbol
  Tmem117
• Name
  transmembrane protein 117
• Synonyms
  B930062P21Rik

• Feature Type
  protein coding gene
• IDs
  MGI:2444580
  NCBI Gene: 320709
• Gene Overview
  MyGene.info: TMEM117
• Alliance
  gene page
• Transcription Start Sites
  5 TSS

Location &
Maps

• Sequence Map
  Chr15:94629232-95096098 bp, + strand
• From Ensembl annotation of GRCm38
  

  View this region in JBrowse
  
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 15, 48.65 cM
• Mapping Data
  1 experiment

Strain
Comparison

• SNPs within 2kb
  3776 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2444580	protein coding gene	Chr15:94629185-95096098 (.)
129S1/SvImJ	MGP_129S1SvImJ_G0022262	protein coding gene	Chr15:96096819-96589349 (+)
A/J	MGP_AJ_G0022221	protein coding gene	Chr15:92356704-92834625 (+)
AKR/J	MGP_AKRJ_G0022196	protein coding gene	Chr15:95146099-95633101 (+)
BALB/cJ	MGP_BALBcJ_G0022227	protein coding gene	Chr15:92522427-93003209 (+)
C3H/HeJ	MGP_C3HHeJ_G0021997	protein coding gene	Chr15:95163287-95650602 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0022672	protein coding gene	Chr15:99648220-100159369 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020198	protein coding gene	Chr15:88383990-88844527 (+)
CAST/EiJ	MGP_CASTEiJ_G0021519	protein coding gene	Chr15:95986283-96489302 (+)
CBA/J	MGP_CBAJ_G0021964	protein coding gene	Chr15:102971654-103500758 (+)
DBA/2J	MGP_DBA2J_G0022091	protein coding gene	Chr15:91803876-92277240 (+)
FVB/NJ	MGP_FVBNJ_G0022070	protein coding gene	Chr15:90808833-91281741 (+)
LP/J	MGP_LPJ_G0022162	protein coding gene	Chr15:96221285-96718278 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022090	protein coding gene	Chr15:107262673-107788309 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022687	protein coding gene	Chr15:95228777-95717131 (+)
PWK/PhJ	MGP_PWKPhJ_G0021260	protein coding gene	Chr15:91861280-92338413 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0021094	protein coding gene	Chr15:94974969-95484014 (+)
WSB/EiJ	MGP_WSBEiJ_G0021568	protein coding gene	Chr15:95735751-96216926 (+)

Homology

• Human Ortholog
  TMEM117, transmembrane protein 117

• Vertebrate Orthologs
  10

• Human Ortholog
  TMEM117, transmembrane protein 117
  Orthology source: HomoloGene, HGNC
• Links
  HGNC:25308

  NCBI Gene ID: 84216

  neXtProt AC: NX_Q9H0C3

  UniProt: Q9H0C3

  
  
• Chr Location
  12q12; chr12:43795806-44389762 (+)  GRCh38.p7

---

• HomoloGene
  Vertebrate Homology Class 12992
  1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  
• HCOP
  human homology predictions: TMEM117
• Gene Tree
  Tmem117
  

Human Diseases

• References
  1 with disease annotations

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  23 phenotype references
  

• All Mutations and Alleles
  8
• Chemically induced (other)
  1
• Gene trapped
  3
• Radiation induced
  2
• Targeted
  2
• Genomic Mutations
  3 involving Tmem117
• Incidental Mutations
  Mutagenetix , APF , CvDC
• Find Mice (IMSR)
  28 strains or lines available

Gene Ontology
(GO)
Classifications

• All GO Annotations
  6
• GO References
  2

• External Resources
  FuncBase

Expression

• cDNA Data
  7

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  Xenbase tmem117
  ZFIN tmem117

Interactions

• Tmem117 interacts with 230 markers (Mir1a-1, Mir1a-2, Mir1b, ...) View All

Sequences &
Gene Models

• All Sequences
  34
• RefSeq
  2
• UniProt
  1
• CCDS
  CCDS27774.1

• Ensembl
  ENSMUSG00000063296 (Evidence)
• NCBI Gene
  320709

Representative Sequences			Length	Strain/Species
genomic	ENSMUSG00000063296	Ensembl Gene Model | MGI Sequence Detail	466867	C57BL/6J
transcript	ENSMUST00000080141	Ensembl | MGI Sequence Detail	2717	Not Applicable
polypeptide	ENSMUSP00000079038	Ensembl | MGI Sequence Detail	514	Not Applicable

Protein
Information

• UniProt
  1 Sequence
• Protein Ontology
  PR:000032756 transmembrane protein 117
  (term hierarchy)
• InterPro Domains
  IPR029370 TMEM117 protein

Molecular
Reagents

• All nucleic 7

  cDNA 7

  
  

  Microarray probesets 3

References

• Summaries
  All 41

  Diseases 1

  Gene Ontology 2

  Phenotypes 23
• Earliest
  J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
• Latest
  J:233611 Hirata A, et al., Homeobox family Hoxc localization during murine palate formation. Congenit Anom (Kyoto). 2016 Jul;56(4):172-9

TSS for Tmem117:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr132785	Chr15:94628906-94628922 (+)	-318 bp
Tssr132786	Chr15:94629082-94629129 (+)	-126 bp
Tssr132787	Chr15:94629148-94629159 (+)	-78 bp
Tssr132788	Chr15:94629236-94629270 (+)	21 bp
Tssr4700	Chr15:94715346-94715350 (+)	86,116 bp