About   Help   FAQ
Rnf165 Gene Detail
Summary
  • Symbol
    Rnf165
  • Name
    ring finger protein 165
  • Synonyms
    2900024M11Rik, Ark2c, G630064H08Rik, LOC225743
  • Feature Type
    protein coding gene
  • IDs
    MGI:2444521
    NCBI Gene: 225743
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:77456110-77565136 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 52.28 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    661 from dbSNP Build 142
  • Strain Annotations
    14
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2444521
 protein coding gene Chr18:77456110-77565161 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024576
 protein coding gene Chr18:78224913-78349246 (-)
A/J MGP_AJ_G0024543
 protein coding gene Chr18:74810158-74912987 (-)
AKR/J MGP_AKRJ_G0024514
 protein coding gene Chr18:76988202-77098526 (-)
BALB/cJ MGP_BALBcJ_G0024542
 protein coding gene Chr18:75017739-75129562 (-)
C3H/HeJ MGP_C3HHeJ_G0024311
 protein coding gene Chr18:77117600-77227101 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024989
 protein coding gene Chr18:80287576-80395784 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022419
 protein coding gene Chr18:73801892-73910321 (-)
CAST/EiJ MGP_CASTEiJ_G0023783
 protein coding gene Chr18:77412380-77529541 (-)
CBA/J MGP_CBAJ_G0024280
 protein coding gene Chr18:83117181-83252497 (-)
DBA/2J MGP_DBA2J_G0024410
 protein coding gene Chr18:74373838-74484942 (-)
FVB/NJ no annotation
LP/J MGP_LPJ_G0024494
 protein coding gene Chr18:78115367-78232655 (-)
NOD/ShiLtJ no annotation
NZO/HlLtJ MGP_NZOHlLtJ_G0025037
 protein coding gene Chr18:77184584-77297264 (-)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0023847
 protein coding gene Chr18:77140154-77257651 (-)



Homology
more
  • Human Ortholog
    RNF165, ring finger protein 165
  • Vertebrate Orthologs
    9
  • Human Ortholog
    RNF165, ring finger protein 165
    Orthology source: HomoloGene, HGNC
  • Synonyms
    Ark2C, ARKL2, RNF111L2
  • Links
    NCBI Gene ID: 494470
    neXtProt AC: NX_Q6ZSG1
    UniProt: Q6ZSG1

  • Chr Location
    18q21.1; chr18:46334217-46461413 (+)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotypes from 1 allele in 1 genetic background
    7 phenotypes from multigenic genotypes
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap allele exhibit partial neonatal lethality followed by complete postnatal lethality, growth retardation, abnormal joint mobility, cyanosis, abnormal motor neuron innervation pattern and abnormal phrenic nerve innervation pattern to diaphragm.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    23
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    632
  • Tissues
    1
  • cDNA Data
    9
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 225743 NCBI Gene Model | MGI Sequence Detail 109027 C57BL/6J ±  kb
    transcript NM_001164504 RefSeq | MGI Sequence Detail 7321 C57BL/6  
    polypeptide E9QAU8 UniProt | EBI | MGI Sequence Detail 347 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 10
      Genomic 1
      cDNA 9

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:1920120, MGI:2147222, MGI:2684942
    References
    more
    • Summaries
      All 31
      Developmental Gene Expression 2
      Gene Ontology 4
      Phenotypes 7
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:198828 Kelly CE, et al., Rnf165/Ark2C enhances BMP-Smad signaling to mediate motor axon extension. PLoS Biol. 2013;11(4):e1001538
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.     		last database update
    02/16/2021
    MGI 6.16     		The Jackson Laboratory