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Fitm2 Gene Detail
Summary
  • Symbol
    Fitm2
  • Name
    fat storage-inducing transmembrane protein 2
  • Synonyms
    D930001I22Rik, Fit2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2444508
    NCBI Gene: 228859
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:163468703-163472629 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 84.29 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    76 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2444508
protein coding gene Chr2:163466379-163472629 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026823
protein coding gene Chr2:168813619-168819869 (-)
A/J MGP_AJ_G0026789
protein coding gene Chr2:162015061-162021311 (-)
AKR/J MGP_AKRJ_G0026760
protein coding gene Chr2:166804016-166810266 (-)
BALB/cJ MGP_BALBcJ_G0026798
protein coding gene Chr2:162339023-162345273 (-)
C3H/HeJ MGP_C3HHeJ_G0026540
protein coding gene Chr2:167155619-167161869 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027246
protein coding gene Chr2:173745455-173751705 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024616
protein coding gene Chr2:155308848-155315153 (-)
CAST/EiJ MGP_CASTEiJ_G0026001
protein coding gene Chr2:167539622-167545925 (-)
CBA/J MGP_CBAJ_G0026517
protein coding gene Chr2:180033144-180039394 (-)
DBA/2J MGP_DBA2J_G0026655
protein coding gene Chr2:161178703-161184953 (-)
FVB/NJ MGP_FVBNJ_G0026621
protein coding gene Chr2:159554467-159560717 (-)
LP/J MGP_LPJ_G0026758
protein coding gene Chr2:168947071-168953321 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026643
protein coding gene Chr2:183682117-183688367 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027302
protein coding gene Chr2:166686829-166693079 (-)
PWK/PhJ MGP_PWKPhJ_G0025735
protein coding gene Chr2:160738414-160744725 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025538
protein coding gene Chr2:165563045-165569343 (-)
WSB/EiJ MGP_WSBEiJ_G0026071
protein coding gene Chr2:167546345-167552777 (-)



Homology
more
  • Human Ortholog
    FITM2, fat storage inducing transmembrane protein 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    FITM2, fat storage inducing transmembrane protein 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    C20orf142, dJ881L22.2, Fit2
  • Links
    NCBI Gene ID: 128486
    neXtProt AC: NX_Q8N6M3
    UniProt: Q8N6M3

  • Chr Location
    20q13.12; chr20:44306557-44311249 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 35254
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: FITM2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    21 phenotypes from 2 alleles in 2 genetic backgrounds
    3 phenotypes from multigenic genotypes
    5 images
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 228859 NCBI Gene Model | MGI Sequence Detail 3927 C57BL/6J ±  kb
    transcript NM_173397 RefSeq | MGI Sequence Detail 1643 C57BL/6  
    polypeptide P59266 UniProt | EBI | MGI Sequence Detail 262 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 68
      cDNA 68

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2138930
    References
    more
    • Summaries
      All 38
      Developmental Gene Expression 1
      Gene Ontology 9
      Phenotypes 9
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:228563 Koscielny G, et al., The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Nucleic Acids Res. 2014 Jan;42(Database issue):D802-9

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory