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Cilp
Gene Detail
 Symbol
Name
ID
Cilp
cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
MGI:2444507
Synonyms C130036G17Rik
Feature Type protein coding gene
Genetic Map
Chromosome 9
35.20 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr9:65265180-65280605 bp, + strand
From VEGA annotation of GRCm38

  15426 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2679  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Cilp

Human
homologs
Human Homolog CILP, cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
NCBI Gene ID 8483
neXtProt AC  NX_O75339
Human Synonyms  CILP-1, HsT18872
Human Chr (Location)  15q22; chr15:65195999-65211502 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human CILP
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Cilp interacts with 407 markers (Mir7-2, Mir7b, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (6 annotations)
Process negative regulation of insulin-like growth factor receptor signaling pathway
Component extracellular matrix, extracellular region, ...
Function molecular_function
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (57)    Tissues (5)    Images (20)
Theiler Stages: 23
Assay TypeResults
RNA in situ 57
cDNA source data(20)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(20) cDNA(20)
Microarray probesets(1)
Other database
links
VEGA Gene ModelOTTMUSG00000016695 (Evidence)
Ensembl Gene ModelENSMUSG00000042254 (Evidence)
Entrez Gene214425 (Evidence)
UniGene138455
DFCITC1584793
DoTSDT.101324835, DT.40152322
NIA Mouse Gene IndexU010632
Consensus CDS ProjectCCDS23287.1
International Mouse Knockout Project StatusCilp
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016695 VEGA Gene Model | MGI Sequence Detail 15426 C57BL/6J ±  kb
transcript OTTMUST00000040435 VEGA | MGI Sequence Detail 4153 Not Applicable 
polypeptide OTTMUSP00000018063 VEGA | MGI Sequence Detail 1250 Not Applicable 

For the selected sequences
All sequences(24) RefSeq(2) UniProt(2)
Polymorphisms SNPs within 2kb(121 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003598 Immunoglobulin subtype 2
InterPro IPR000884 Thrombospondin, type 1 repeat
InterPro IPR025155 WxxW domain
Protein Ontology PR:000005495 cartilage intermediate layer protein 1
References (Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:177564 Bernardo BC, et al., Cartilage Intermediate Layer Protein 2 (CILP-2) Is Expressed in Articular and Meniscal Cartilage and Down-regulated in Experimental Osteoarthritis. J Biol Chem. 2011 Oct 28;286(43):37758-67
All references(26)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory