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Arhgef10
Gene Detail
Symbol

Name
ID
Arhgef10
Rho guanine nucleotide exchange factor (GEF) 10
MGI:2444453
Synonyms
6430549H08Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 8
7.59 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr8:14911663-15001085 bp, + strand
From VEGA annotation of GRCm38

  89423 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:22827  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Arhgef10

Human
homologs
Human Homolog ARHGEF10, Rho guanine nucleotide exchange factor (GEF) 10
NCBI Gene ID 9639
neXtProt AC  NX_O15013
Human Synonyms  GEF10, SNCV
Human Chr (Location)  8p23; chr8:1823983-1958641 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human ARHGEF10
Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(8) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Arhgef10 interacts with 242 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process centrosome duplication, myelination in peripheral nervous system, ...
Component centrosome
Function guanyl-nucleotide exchange factor activity, kinesin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (36)    Tissues (22)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 20
Northern blot 7
RT-PCR 9
cDNA source data(75)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(79) cDNA(75) Primer pair(3) Other(1)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000034037 (Evidence)
Ensembl Gene ModelENSMUSG00000071176 (Evidence)
Entrez Gene234094 (Evidence)
UniGene240298
DFCITC1578820, TC1590490, TC1623985, TC1619002
DoTSDT.102556126, DT.491408, DT.91347392, DT.40177216
NIA Mouse Gene IndexU009122
Consensus CDS ProjectCCDS40240.1, CCDS40241.1
International Mouse Knockout Project StatusArhgef10
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034037 VEGA Gene Model | MGI Sequence Detail 89423 C57BL/6J ±  kb
transcript OTTMUST00000085947 VEGA | MGI Sequence Detail 5528 Not Applicable 
polypeptide OTTMUSP00000046476 VEGA | MGI Sequence Detail 1345 Not Applicable 

For the selected sequences
All sequences(86) RefSeq(24) UniProt(7)
Polymorphisms
SNPs within 2kb(814 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000219 Dbl homology (DH) domain
InterPro IPR011993 Pleckstrin homology-like domain
InterPro IPR017986 WD40-repeat-containing domain
InterPro IPR015943 WD40/YVTN repeat-like-containing domain
Protein Ontology PR:000004246 rho guanine nucleotide exchange factor 10
References
(Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:184769 Xue W, et al., A cluster of cooperating tumor-suppressor gene candidates in chromosomal deletions. Proc Natl Acad Sci U S A. 2012 May 22;109(21):8212-7
All references(33)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory