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Arhgef10 Gene Detail
Summary
  • Symbol
    Arhgef10
  • Name
    Rho guanine nucleotide exchange factor (GEF) 10
  • Synonyms
    6430549H08Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2444453
    NCBI Gene: 234094
  • Gene Overview
    MyGene.info: ARHGEF10
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:14911663-15001085 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 7.59 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    805 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2444453
protein coding gene Chr8:14908494-15001085 (.)
129S1/SvImJ MGP_129S1SvImJ_G0033398
protein coding gene Chr8:12332872-12429496 (+)
A/J MGP_AJ_G0033379
protein coding gene Chr8:11905277-11998171 (+)
AKR/J MGP_AKRJ_G0033309
protein coding gene Chr8:12203218-12295369 (+)
BALB/cJ MGP_BALBcJ_G0033379
protein coding gene Chr8:11980832-12070824 (+)
C3H/HeJ MGP_C3HHeJ_G0033092
protein coding gene Chr8:12427086-12523336 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033891
protein coding gene Chr8:12700877-12803798 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030857
protein coding gene Chr8:11305018-11396863 (+)
CAST/EiJ MGP_CASTEiJ_G0032414
protein coding gene Chr8:12237808-12336750 (+)
CBA/J MGP_CBAJ_G0033065
protein coding gene Chr8:13256364-13352191 (+)
DBA/2J MGP_DBA2J_G0033219
protein coding gene Chr8:11818351-11907888 (+)
FVB/NJ MGP_FVBNJ_G0033167
protein coding gene Chr8:11843715-11939388 (+)
LP/J MGP_LPJ_G0033312
protein coding gene Chr8:12306468-12404052 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033204
protein coding gene Chr8:13465402-13566205 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033908
protein coding gene Chr8:12286381-12376703 (+)
PWK/PhJ MGP_PWKPhJ_G0032127
protein coding gene Chr8:11881281-11973867 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031968
protein coding gene Chr8:12159720-12257809 (+)
WSB/EiJ MGP_WSBEiJ_G0032530
protein coding gene Chr8:12308547-12409342 (+)



Homology
more
  • Human Ortholog
    ARHGEF10, Rho guanine nucleotide exchange factor 10
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ARHGEF10, Rho guanine nucleotide exchange factor 10
    Orthology source: HGNC, HomoloGene
  • Synonyms
    GEF10, SNCV
  • Links
    NCBI Gene ID: 9639
    neXtProt AC: NX_O15013
    UniProt: O15013

  • Chr Location
    8p23.3; chr8:1823976-1958641 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000071176 Ensembl Gene Model | MGI Sequence Detail 89423 C57BL/6J ±  kb
transcript ENSMUST00000084207 Ensembl | MGI Sequence Detail 5528 Not Applicable  
polypeptide ENSMUSP00000081225 Ensembl | MGI Sequence Detail 1345 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000004246 rho guanine nucleotide exchange factor 10
  • InterPro Domains
    IPR000219 Dbl homology (DH) domain
    IPR035899 Dbl homology (DH) domain superfamily
    IPR030632 Rho guanine nucleotide exchange factor 10
    IPR039919 Rho guanine nucleotide exchange factor 10/17
    IPR036322 WD40-repeat-containing domain superfamily
    IPR015943 WD40/YVTN repeat-like-containing domain superfamily
Molecular
Reagents
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  • All nucleic 80
    cDNA 76
    Primer pair 3
    Other 1

    Microarray probesets 6
References
more
  • Summaries
    All 33
    Developmental Gene Expression 3
    Gene Ontology 4
    Phenotypes 7
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:246066 Sundberg JP, et al., Systematic screening for skin, hair, and nail abnormalities in a large-scale knockout mouse program. PLoS One. 2017;12(7):e0180682

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/04/2018
MGI 6.13
The Jackson Laboratory