Arhgef10
Gene Detail

Symbol Name ID

Arhgef10 Rho guanine nucleotide exchange factor (GEF) 10 MGI:2444453

Synonyms

6430549H08Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 8

7.59 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr8:14911663-15001085 bp, + strand From VEGA annotation of GRCm38   89423 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:22827  Vertebrate Homology Class
1 human; 1 mouse; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Arhgef10

Human homologs

Human Homolog		ARHGEF10, Rho guanine nucleotide exchange factor (GEF) 10
NCBI Gene ID		9639
neXtProt AC		NX_O15013
Human Synonyms		GEF10
Human Chr (Location)		8p23; chr8:1772149-1906807 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human ARHGEF10

Alleles and phenotypes

All alleles(9) : Targeted(1) Gene trapped(8)

Gene Ontology (GO) classifications

All GO classifications: (11 annotations)

Process	centrosome duplication, myelination in peripheral nervous system, ...
Component	centrosome
Function	guanyl-nucleotide exchange factor activity, kinesin binding, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (36)    Tissues (22)    Images (1)
Theiler Stages: 13, 15, 20, 21, 25, 28

Assay Type	Results
RNA in situ	20
Northern blot	7
RT-PCR	9

cDNA source data(75)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(79) cDNA(75) Primer pair(3) Other(1)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000034037 (Evidence)
Ensembl Gene Model	ENSMUSG00000071176 (Evidence)
Entrez Gene	234094 (Evidence)
UniGene	240298
DFCI	TC1578820, TC1590490, TC1619002, TC1623985
DoTS	DT.40177216, DT.102556126, DT.491408, DT.91347392
NIA Mouse Gene Index	U009122
Consensus CDS Project	CCDS40240.1, CCDS40241.1
International Mouse Knockout Project Status	Arhgef10

Sequences

Length	Strain/Species
genomic	OTTMUSG00000034037	VEGA Gene Model | MGI Sequence Detail	89423	C57BL/6J
transcript	OTTMUST00000085947	VEGA | MGI Sequence Detail	5528	Not Applicable
polypeptide	OTTMUSP00000046476	VEGA | MGI Sequence Detail	1345	Not Applicable

All sequences(62) RefSeq(4) UniProt(4)

Polymorphisms

SNPs(639 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000219	Dbl homology (DH) domain
InterPro	IPR011993	Pleckstrin homology-like domain
InterPro	IPR017986	WD40-repeat-containing domain
InterPro	IPR015943	WD40/YVTN repeat-like-containing domain
Protein Ontology	PR:000004246	rho guanine nucleotide exchange factor 10

References

(Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:184769 Xue W, et al., A cluster of cooperating tumor-suppressor gene candidates in chromosomal deletions. Proc Natl Acad Sci U S A. 2012 May 22;109(21):8212-7
All references(32)