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Phf8
Gene Detail
Symbol

Name
ID
Phf8
PHD finger protein 8
MGI:2444341
Synonyms
9830141C09Rik, mKIAA1111
Feature Type
protein coding gene
Genetic Map
Chromosome X
68.46 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
ChrX:151520672-151633859 bp, + strand
From VEGA annotation of GRCm38

  113188 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:49405  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Gene Tree: Phf8

Human
homologs
Human Homolog PHF8, PHD finger protein 8
NCBI Gene ID 23133
neXtProt AC  NX_Q9UPP1
Human Synonyms  JHDM1F, MRXSSD, ZNF422
Human Chr (Location)  Xp11.22; chrX:53936680-54048935 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human PHF8
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(5) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Phf8 interacts with 337 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process G1/S transition of mitotic cell cycle, histone H3-K27 demethylation, ...
Component microtubule cytoskeleton, nucleolus, ...
Function chromatin binding, histone demethylase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (147)    Tissues (135)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 131
RT-PCR 16
cDNA source data(98)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(101) cDNA(98) Primer pair(3)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000017224 (Evidence)
Ensembl Gene ModelENSMUSG00000041229 (Evidence)
Entrez Gene320595 (Evidence)
UniGene17156
DFCITC1582399, TC1587816, TC1601215, TC1604501, TC1624158
DoTSDT.101151035, DT.101203845, DT.101736677, DT.111037463, DT.50316512, DT.55215870, DT.87057064, DT.97345501
NIA Mouse Gene IndexU020316
Consensus CDS ProjectCCDS30470.1, CCDS53223.1
International Mouse Knockout Project StatusPhf8
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017224 VEGA Gene Model | MGI Sequence Detail 113188 C57BL/6J ±  kb
transcript OTTMUST00000041702 VEGA | MGI Sequence Detail 5728 Not Applicable 
polypeptide OTTMUSP00000018732 VEGA | MGI Sequence Detail 1023 Not Applicable 

For the selected sequences
All sequences(88) RefSeq(16)
Polymorphisms
SNPs within 2kb(317 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
Protein Ontology PR:000012655 histone lysine demethylase PHF8
References
(Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:199665 Asensio-Juan E, et al., The histone demethylase PHF8 is essential for cytoskeleton dynamics. Nucleic Acids Res. 2012 Oct;40(19):9429-40
All references(36)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory