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Nalcn
Gene Detail
Symbol

Name
ID
Nalcn
sodium leak channel, non-selective
MGI:2444306
Synonyms
A530023G15Rik, Vgcnl1
Feature Type
protein coding gene
Genetic Map
Chromosome 14
66.04 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr14:123276641-123627144 bp, - strand
From Ensembl annotation of GRCm38

  350504 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:21832  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: NALCN
Protein SuperFamily: sodium leak channel non-selective protein
Gene Tree: Nalcn

Human
homologs
NALCN, sodium leak channel, non selective
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 259232
neXtProt AC: NX_Q8IZF0

Human Synonyms: bA430M15.1, CanIon, CLIFAHDD, IHPRF, INNFD, VGCNL1

Human Chr (Location): 13q32.3; chr13:101053776-101417205 (-)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human NALCN

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(2) Targeted(6)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a null allele exhibit abnormal breathing at birth and die within 24 hours.
 
Interactions
Nalcn interacts with 297 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process calcium ion import, calcium ion transmembrane transport, ...
Component integral component of membrane, membrane, ...
Function cation channel activity, ion channel activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (12)    Tissues (10)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 9
RT-PCR 3
cDNA source data(11)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase nalcn ; ZFIN nalcn    NEW 
Molecular
reagents
All nucleic(12) cDNA(11) Primer pair(1)
Microarray probesets(6)
Other database
links
Ensembl Gene Model ENSMUSG00000000197 (Evidence)
Entrez Gene 338370 (Evidence)
DFCI TC1614876, TC1646036, TC1596630, TC1591981, TC1588709, TC1710157, TC1698519, TC1654305
DoTS DT.101723166, DT.91315201, DT.91398842, DT.94220586, DT.91580562, DT.91553365
Consensus CDS Project CCDS37023.1
International Mouse Phenotyping Consortium Status Nalcn
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000000197 Ensembl Gene Model | MGI Sequence Detail 350504 C57BL/6J ±  kb
transcript ENSMUST00000000201 Ensembl | MGI Sequence Detail 7115 Not Applicable 
polypeptide ENSMUSP00000000201 Ensembl | MGI Sequence Detail 1739 Not Applicable 

For the selected sequences
All sequences(43) RefSeq(11) UniProt(2)
Polymorphisms
SNPs within 2kb(1059 from dbSNP Build 137)    SNPs within 2kb including multiple locations(1061)
Protein-related
information
ResourceIDDescription
InterPro IPR005821 Ion transport domain
InterPro IPR027359 Voltage-dependent potassium channel, four helix bundle domain
Protein Ontology PR:000000678 sodium leak channel non-selective protein
References
(Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(32)
Other
accession IDs
MGI:3034847

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory