Ssc3 QTL Detail

Summary

• Symbol
  Ssc3
• Name
  serum sodium concentration 3, 12 mos, females only

• Feature Type
  QTL
• IDs
  MGI:7286096
• Candidate Genes
  1 Gene

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.

• Genetic Map
  Chromosome 14, cM position of peak correlated region/marker: Syntenic
• Mapping Data
  2 experiments

References

• Summaries
  All 1
• Earliest
  J:171768 Sinke AP, et al., Genetic analysis of mouse strains with variable serum sodium concentrations identifies the Nalcn sodium channel as a novel player in osmoregulation. Physiol Genomics. 2011 Mar 16;43(5):265-70

Candidate Genes for Ssc3:

Gene	Genome Location (GRCm39)	Reference	QTL Note
Nalcn	Chr14:123514046-123864556 (-)	J:171768	Ssc3 (serum sodium concentration 3, 12 mos, female) maps to Chr 14 and contains only one known gene (Nalcn; MGI:2444306). Within this locus three different haplotypes could be distinguished, which associated with different average serum sodium levels. The association of Nalcn with sodium levels was confirmed by analysis of heterozygous Nalcn knockout mice, which displayed hypernatremia compared with wild-type littermates.