Dennd5b MGI Mouse Gene Detail - MGI:2444273

Symbol

Dennd5b
Name

DENN domain containing 5B
Synonyms

9330160C06Rik, D030011O10Rik

Feature Type

protein coding gene
IDs

MGI:2444273
NCBI Gene: 320560
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr6:148889569-149003178 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 78.71 cM
Mapping Data

3 experiments

SNPs within 2kb

382 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2444273	protein coding gene	Chr6:148889566-149003178 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0031507	protein coding gene	Chr6:154100430-154216702 (-)
A/J	MGP_AJ_G0031482	protein coding gene	Chr6:147990807-148104851 (-)
AKR/J	MGP_AKRJ_G0031410	protein coding gene	Chr6:152405242-152524122 (-)
BALB/cJ	MGP_BALBcJ_G0031490	protein coding gene	Chr6:147744404-147859360 (-)
C3H/HeJ	MGP_C3HHeJ_G0031211	protein coding gene	Chr6:152459069-152577290 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0031951	protein coding gene	Chr6:158194025-158336865 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0029075	protein coding gene	Chr6:146704579-146820482 (-)
CAST/EiJ	MGP_CASTEiJ_G0030580	protein coding gene	Chr6:152132014-152251631 (-)
CBA/J	MGP_CBAJ_G0031171	protein coding gene	Chr6:164287637-164411534 (-)
DBA/2J	MGP_DBA2J_G0031327	protein coding gene	Chr6:146777062-146901445 (-)
FVB/NJ	MGP_FVBNJ_G0031279	protein coding gene	Chr6:145468532-145582889 (-)
LP/J	MGP_LPJ_G0031413	protein coding gene	Chr6:154243296-154359417 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0031319	protein coding gene	Chr6:167921765-168042381 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0031984	protein coding gene	Chr6:152250940-152387713 (-)
PWK/PhJ	MGP_PWKPhJ_G0030306	protein coding gene	Chr6:145303434-145421890 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0030130	protein coding gene	Chr6:150348193-150461883 (-)
WSB/EiJ	MGP_WSBEiJ_G0030673	protein coding gene	Chr6:152866895-152985660 (-)

Human Ortholog

DENND5B, DENN domain containing 5B

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DENND5B, DENN domain containing 5B
Links

HGNC:28338

NCBI Gene ID: 160518

neXtProt AC: NX_Q6ZUT9

UniProt: Q6ZUT9
Chr Location

12p11.21; chr12:31382226-31591136 (-) GRCh38

MGI Vertebrate Homology

Dennd5b stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: DENND5B
Gene Tree

Dennd5b

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Phenotype Summary

42 phenotypes from 3 alleles in 3 genetic backgrounds
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

89
Chemically induced (ENU)

1
Endonuclease-mediated

2
Gene trapped

84
Targeted

2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

202 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Knockout decreases triglyceride absorption, and reduces susceptibility to weight gain and atherosclerosis when fed Western diet. Mice homozygous for an ENU-induced allele exhibit normal blood lymphocyte populations.

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All GO Annotations

6
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

48
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase dennd5b

ZFIN dennd5b

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All Sequences

66
RefSeq

12
UniProt

4
CCDS

CCDS20714.2

Ensembl

ENSMUSG00000030313 (Evidence)
NCBI Gene

320560

			Length	Strain/Species	Flank
genomic	ENSMUSG00000030313	Ensembl Gene Model \| MGI Sequence Detail	113610	C57BL/6J	± kb
transcript	ENSMUST00000111557	Ensembl \| MGI Sequence Detail	9831	Not Applicable
polypeptide	ENSMUSP00000107182	Ensembl \| MGI Sequence Detail	1274	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000029405 DENN domain-containing protein 5B

(term hierarchy)
InterPro Domains

IPR001194 cDENN domain

IPR005112 dDENN domain

IPR047278 DENN domain-containing protein 5A/B

IPR047277 DENN domain-containing protein 5A/B, PLAT/LH2 domain

IPR047293 DENN domain-containing protein 5B, first RUN domain

IPR047292 DENN domain-containing protein 5B, second RUN domain

IPR043153 DENN domain, C-terminal lobe

IPR001024 PLAT/LH2 domain

IPR036392 PLAT/LH2 domain superfamily

IPR004012 RUN domain

IPR037213 RUN domain superfamily

IPR037516 Tripartite DENN domain

IPR005113 uDENN domain

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All nucleic 49

cDNA 49

Microarray probesets 7

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MGI:2141506, MGI:2442876, MGI:3641775

Summaries

All 32

Developmental Gene Expression 1

Gene Ontology 5

Phenotypes 9
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:303495 Iwaki A, et al., Loss of Rab6a in the small intestine causes lipid accumulation and epithelial cell death from lactation. FASEB J. 2020 Jul;34(7):9450-9465

TSS for Dennd5b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr64172	Chr6:149003172-149003184 (-)	0 bp
Tssr64171	Chr6:149003004-149003087 (-)	132 bp
Tssr64170	Chr6:149001873-149001877 (-)	1,303 bp
Tssr64169	Chr6:148893913-148893925 (-)	109,259 bp
Tssr64168	Chr6:148890831-148890836 (-)	112,344 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23