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Hecw1 Gene Detail
Summary
  • Symbol
    Hecw1
  • Name
    HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
  • Synonyms
    E130207I19Rik, NEDL1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2444115
    NCBI Gene: 94253
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:14226438-14523228 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 5.29 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1218 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2444115
protein coding gene Chr13:14226438-14523279 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020243
protein coding gene Chr13:11195425-11504474 (-)
A/J MGP_AJ_G0020201
protein coding gene Chr13:11117621-11418661 (-)
AKR/J MGP_AKRJ_G0020175
protein coding gene Chr13:11242365-11556316 (-)
BALB/cJ MGP_BALBcJ_G0020187
protein coding gene Chr13:11099777-11393343 (-)
C3H/HeJ MGP_C3HHeJ_G0019991
protein coding gene Chr13:11407740-11712682 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020631
protein coding gene Chr13:11785642-12126006 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018237
protein coding gene Chr13:9839882-10115321 (-)
CAST/EiJ MGP_CASTEiJ_G0019524
protein coding gene Chr13:11065632-11377645 (-)
CBA/J MGP_CBAJ_G0019955
protein coding gene Chr13:12152309-12370048 (-)
DBA/2J MGP_DBA2J_G0020074
protein coding gene Chr13:10759351-11064827 (-)
FVB/NJ MGP_FVBNJ_G0020055
protein coding gene Chr13:10534752-10828962 (-)
LP/J MGP_LPJ_G0020144
protein coding gene Chr13:11408207-11718072 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020092
protein coding gene Chr13:12258280-12614363 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020658
protein coding gene Chr13:11054560-11370006 (-)
PWK/PhJ MGP_PWKPhJ_G0019288
protein coding gene Chr13:10856834-11149462 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019095
protein coding gene Chr13:10217288-10526226 (-)
WSB/EiJ MGP_WSBEiJ_G0019586
protein coding gene Chr13:11071897-11378275 (-)



Homology
more
  • Human Ortholog
    HECW1, HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    HECW1, HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    NEDL1
  • Links
    NCBI Gene ID: 23072
    neXtProt AC: NX_Q76N89
    UniProt: Q76N89

  • Chr Location
    7p14.1-p13; chr7:43112580-43566001 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 9004
    1 human;1 mouse;1 rat;1 chimpanzee;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: HECW1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000021301 Ensembl Gene Model | MGI Sequence Detail 296791 C57BL/6J ±  kb
transcript ENSMUST00000110516 Ensembl | MGI Sequence Detail 9460 Not Applicable  
polypeptide ENSMUSP00000106145 Ensembl | MGI Sequence Detail 1604 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 31
    Genomic 4
    cDNA 25
    Primer pair 2

    Microarray probesets 5
Other
Accession IDs
less
MGI:2137556, MGI:2442515
References
more
  • Summaries
    All 31
    Developmental Gene Expression 2
    Gene Ontology 5
    Phenotypes 4
  • Earliest
    J:70256 Martin N, et al., Genetic and physical delineation of the region overlapping the progressive motor neuropathy (pmn) locus on mouse chromosome 13. Genomics. 2001 Jul;75(1-3):9-16
  • Latest
    J:236569 Inaba H, et al., Ndel1 suppresses ciliogenesis in proliferating cells by regulating the trichoplein-Aurora A pathway. J Cell Biol. 2016 Feb 15;212(4):409-23

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory