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Nlrp10 Gene Detail
Summary
  • Symbol
    Nlrp10
  • Name
    NLR family, pyrin domain containing 10
  • Synonyms
    6430548I20Rik, Nalp10, Pynod
  • Feature Type
    protein coding gene
  • IDs
    MGI:2444084
    NCBI Gene: 244202
  • Gene Overview
    MyGene.info: NLRP10
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:108921853-108930158 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 57.21 cM, cytoband E3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    88 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2444084
protein coding gene Chr7:108921852-108930178 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032835
protein coding gene Chr7:112319288-112330377 (-)
A/J MGP_AJ_G0032819
protein coding gene Chr7:109544326-109569701 (-)
AKR/J MGP_AKRJ_G0032750
protein coding gene Chr7:112285981-112301197 (-)
BALB/cJ MGP_BALBcJ_G0032823
protein coding gene Chr7:109255942-109264235 (-)
C3H/HeJ MGP_C3HHeJ_G0032533
protein coding gene Chr7:112331324-112338676 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033329
protein coding gene Chr7:117009823-117020046 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030302
protein coding gene Chr7:111151075-111157998 (-)
CAST/EiJ MGP_CASTEiJ_G0031861
protein coding gene Chr7:103853350-103861565 (-)
CBA/J MGP_CBAJ_G0032506
protein coding gene Chr7:120833347-120844702 (-)
DBA/2J MGP_DBA2J_G0032658
protein coding gene Chr7:107666479-107676707 (-)
FVB/NJ MGP_FVBNJ_G0032611
protein coding gene Chr7:107515480-107523848 (-)
LP/J MGP_LPJ_G0032752
protein coding gene Chr7:113883629-113891946 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032643
protein coding gene Chr7:122514915-122522188 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033350
protein coding gene Chr7:111314002-111323460 (-)
PWK/PhJ MGP_PWKPhJ_G0031568
protein coding gene Chr7:100468545-100477170 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031416
protein coding gene Chr7:98001573-98009765 (-)
WSB/EiJ MGP_WSBEiJ_G0031974
protein coding gene Chr7:112148191-112157832 (-)



Homology
more
  • Human Ortholog
    NLRP10, NLR family pyrin domain containing 10
  • Vertebrate Orthologs
    6
  • Human Ortholog
    NLRP10, NLR family pyrin domain containing 10
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CLR11.1, NALP10, NOD8, PAN5, PYNOD
  • Links
    NCBI Gene ID: 338322
    neXtProt AC: NX_Q86W26
    UniProt: Q86W26

  • Chr Location
    11p15.4; chr11:7959023-7965427 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 1 allele in 2 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele display a global defect in adaptive immune responses with impaired dendritic cell migration to lymph nodes.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 244202 NCBI Gene Model | MGI Sequence Detail 8306 C57BL/6J ±  kb
transcript NM_175532 RefSeq | MGI Sequence Detail 4483 C57BL/6  
polypeptide Q8CCN1 UniProt | EBI | MGI Sequence Detail 673 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 9
    cDNA 8
    Primer pair 1

    Microarray probesets 3
References
more
  • Summaries
    All 41
    Developmental Gene Expression 1
    Gene Ontology 5
    Phenotypes 15
  • Earliest
    J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
  • Latest
    J:251325 Clay GM, et al., An Anti-Inflammatory Role for NLRP10 in Murine Cutaneous Leishmaniasis. J Immunol. 2017 Oct 15;199(8):2823-2833

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/27/2018
MGI 6.13
The Jackson Laboratory