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Nlrp10
Gene Detail
Symbol

Name
ID
Nlrp10
NLR family, pyrin domain containing 10
MGI:2444084
Synonyms
6430548I20Rik, Nalp10, Pynod
Feature Type
protein coding gene
Genetic Map
Chromosome 7
57.21 cM, cytoband E3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr7:108921860-108930158 bp, - strand
From Ensembl annotation of GRCm38

  8299 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:18468  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog

Gene Tree: Nlrp10

Human
homologs
Human Homolog NLRP10, NLR family, pyrin domain containing 10
NCBI Gene ID 338322
neXtProt AC  NX_Q86W26
Human Synonyms  CLR11.1, NALP10, NOD8, PAN5, PYNOD
Human Chr (Location)  11p15.4; chr11:7959609-7963512 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele display a global defect in adaptive immune responses with impaired dendritic cell migration to lymph nodes.
 
Interactions
Nlrp10 interacts with 296 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process defense response, defense response to fungus, ...
Component cytoplasm, extrinsic component of plasma membrane, ...
Function ATP binding, nucleotide binding
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (3)    Tissues (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 3
cDNA source data(7)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(8) cDNA(7) Primer pair(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000049709 (Evidence)
Entrez Gene244202 (Evidence)
DFCITC1587271, TC1611032
DoTSDT.101351551
PDB2DO9
Consensus CDS ProjectCCDS21730.1
International Mouse Knockout Project StatusNlrp10
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000049709 Ensembl Gene Model | MGI Sequence Detail 8299 C57BL/6J ±  kb
transcript ENSMUST00000055745 Ensembl | MGI Sequence Detail 4476 Not Applicable 
polypeptide ENSMUSP00000050252 Ensembl | MGI Sequence Detail 673 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(2) UniProt(4)
Polymorphisms
SNPs within 2kb(88 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003593 AAA+ ATPase domain
InterPro IPR004020 DAPIN domain
InterPro IPR011029 Death-like domain
InterPro IPR007111 NACHT nucleoside triphosphatase
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000011265 NACHT, LRR and PYD domains-containing protein 10
References
(Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:190699 Joly S, et al., Cutting edge: Nlrp10 is essential for protective antifungal adaptive immunity against Candida albicans. J Immunol. 2012 Nov 15;189(10):4713-7
All references(31)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory