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Nlrp10 Gene Detail
Summary
  • Symbol
    Nlrp10
  • Name
    NLR family, pyrin domain containing 10
  • Synonyms
    6430548I20Rik, Nalp10, Pynod
  • Feature Type
    protein coding gene
  • IDs
    MGI:2444084
    NCBI Gene: 244202
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:108521060-108529365 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 57.21 cM, cytoband E3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    259 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2444084
 protein coding gene Chr7:108521059-108529385 (-)
129S1/SvImJ ENSMUSG00200030843
 protein coding gene Chr7:95062187-95070605 (-)
A/J ENSMUSG00195052768
 protein coding gene Chr7:99558484-99566898 (-)
AKR/J ENSMUSG00220036341
 protein coding gene Chr7:92961928-92970346 (-)
BALB/cJ ENSMUSG00180036862
 protein coding gene Chr7:96233575-96241995 (-)
C3H/HeJ ENSMUSG00175045960
 protein coding gene Chr7:96869644-96878064 (-)
C57BL/6NJ ENSMUSG00215048367
 protein coding gene Chr7:96174455-96182873 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030302
 protein coding gene Chr7:111151075-111157998 (-)
CAST/EiJ ENSTCUG00005052838
 protein coding gene Chr7:99535208-99543781 (-)
CBA/J ENSMUSG00210045097
 protein coding gene Chr7:96696791-96705201 (-)
DBA/2J ENSMUSG00185021936
 protein coding gene Chr7:101047035-101055459 (-)
FVB/NJ ENSMUSG00205036850
 protein coding gene Chr7:96653451-96661871 (-)
JF1/MsJ ENSUMUG00000029317
 protein coding gene Chr7:106056675-106064987 (-)
LP/J ENSMUSG00230044918
 protein coding gene Chr7:107148070-107156488 (-)
NOD/ShiLtJ ENSMUSG00190035287
 protein coding gene Chr7:96863119-96871425 (-)
NZO/HlLtJ ENSMUSG00225014980
 protein coding gene Chr7:105368540-105376957 (-)
PWK/PhJ ENSLUMG00010032745
 protein coding gene Chr7:95176682-95185153 (-)
SPRET/EiJ ENSMSPG00010037126
 protein coding gene Chr7:96335858-96341826 (-)
WSB/EiJ ENSIUOG00005046354
 protein coding gene Chr7:97498189-97506647 (-)



Homology
more
  • Human Ortholog
    NLRP10, NLR family pyrin domain containing 10
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NLRP10, NLR family pyrin domain containing 10
  • Synonyms
    CLR11.1, NALP10, NOD8, PAN5, PYNOD
  • Links
    NCBI Gene ID: 338322
    UniProt: Q86W26

  • Chr Location
    11p15.4; chr11:7957537-7965447 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele display a global defect in adaptive immune responses with impaired dendritic cell migration to lymph nodes.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    44
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    600
  • Tissues
    2
  • cDNA Data
    8
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 244202 NCBI Gene Model | MGI Sequence Detail 8306 C57BL/6J ±  kb
transcript NM_175532 RefSeq | MGI Sequence Detail 4483 C57BL/6  
polypeptide Q8CCN1 UniProt | EBI | MGI Sequence Detail 673 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 9
    cDNA 8
    Primer pair 1

    Microarray probesets 3
References
more
  • Summaries
    All 55
    Developmental Gene Expression 1
    Gene Ontology 9
    Phenotypes 24
  • Earliest
    J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
  • Latest
    J:354090 Zheng D, et al., Epithelial Nlrp10 inflammasome mediates protection against intestinal autoinflammation. Nat Immunol. 2023 Apr;24(4):585-594
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/15/2026
MGI 6.29 		The Jackson Laboratory