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Pde8b
Gene Detail
 Symbol
Name
ID
Pde8b
phosphodiesterase 8B
MGI:2443999
Synonyms B230331L10Rik, C030047E14Rik
Feature Type protein coding gene
Genetic Map
Chromosome 13
49.22 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr13:95024454-95250336 bp, - strand
From VEGA annotation of GRCm38

  225883 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2758  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: 3',5'-cyclic-nucleotide phosphodiesterase 8A, high affinity cAMP-specific
Gene Tree: Pde8b

Human
homologs
Human Homolog PDE8B, phosphodiesterase 8B
NCBI Gene ID 8622
neXtProt AC  NX_O95263
Human Synonyms  ADSD, PPNAD3
Human Chr (Location)  5q13.3; chr5:77180257-77428256 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human PDE8B
Alleles
and
phenotypes
All alleles(3) : Targeted(2) Gene trapped(1)
 
Mice homozygous for a knock-out allele exhibit increased uring corticosterone, decreased serum adrenocorticotropin and decreased sensitivity to a PDE8-selective inhibitor.
 
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process negative regulation of insulin secretion, negative regulation of steroid hormone biosynthetic process, ...
Component cellular_component
Function 3',5'-cyclic-AMP phosphodiesterase activity, 3',5'-cyclic-nucleotide phosphodiesterase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (230)    Tissues (163)    Images (34)
Theiler Stages: 22, 23, 26, 28
Assay TypeResults
RNA in situ 230
cDNA source data(32)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(32) cDNA(32)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000032523 (Evidence)
Ensembl Gene ModelENSMUSG00000021684 (Evidence)
Entrez Gene218461 (Evidence)
UniGene100167
DFCITC1581318, TC1591323, TC1594599, TC1597598, TC1610172, TC1612484, TC1773079
DoTSDT.101296728, DT.101341690, DT.101364060, DT.101732290, DT.87043950, DT.91280793, DT.91319098, DT.91324775, DT.91597970, DT.94192105, DT.97360798
NIA Mouse Gene IndexU015133, U035050
EC3.1.4.53
Consensus CDS ProjectCCDS49331.1, CCDS49332.1
International Mouse Knockout Project StatusPde8b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000032523 VEGA Gene Model | MGI Sequence Detail 225883 C57BL/6J ±  kb
transcript OTTMUST00000093586 VEGA | MGI Sequence Detail 2598 Not Applicable 
polypeptide OTTMUSP00000051960 VEGA | MGI Sequence Detail 865 Not Applicable 

For the selected sequences
All sequences(136) RefSeq(26) UniProt(17)
Polymorphisms SNPs within 2kb(1467 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR023088 3'5'-cyclic nucleotide phosphodiesterase
InterPro IPR002073 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
InterPro IPR023174 3'5'-cyclic nucleotide phosphodiesterase, conserved site
InterPro IPR013938 3'5'-cyclic nucleotide phosphodiesterase PDE8
InterPro IPR011006 CheY-like superfamily
InterPro IPR003607 HD/PDEase domain
InterPro IPR000014 PAS domain
InterPro IPR001789 Signal transduction response regulator, receiver domain
Protein Ontology PR:000012487 high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:203335 Tsai LC, et al., The high-affinity cAMP-specific phosphodiesterase 8B controls steroidogenesis in the mouse adrenal gland. Mol Pharmacol. 2011 Apr;79(4):639-48
All references(33)
Other
accession IDs
MGI:1924861

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory