About   Help   FAQ
Pde8b
Gene Detail
Symbol

Name
ID
Pde8b
phosphodiesterase 8B
MGI:2443999
Synonyms
B230331L10Rik, C030047E14Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 13
49.22 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr13:95024454-95250336 bp, - strand
From VEGA annotation of GRCm38

  225883 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2758  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PDE8B
Protein SuperFamily: 3',5'-cyclic-nucleotide phosphodiesterase 8A, high affinity cAMP-specific
Gene Tree: Pde8b

Human
homologs
PDE8B, phosphodiesterase 8B
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 8622
neXtProt AC: NX_O95263

Human Synonyms: ADSD, PPNAD3

Human Chr (Location): 5q13.3; chr5:77180262-77428256 (+)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human PDE8B

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Gene trapped(1) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit increased uring corticosterone, decreased serum adrenocorticotropin and decreased sensitivity to a PDE8-selective inhibitor.
 
Interactions
Pde8b interacts with 254 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (3 records)
Data Summary: Results (230)    Tissues (163)    Images (34)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 230
cDNA source data(32)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase pde8b    NEW 
Molecular
reagents
All nucleic(32) cDNA(32)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000032523 (Evidence)
Ensembl Gene Model ENSMUSG00000021684 (Evidence)
Entrez Gene 218461 (Evidence)
UniGene 100167
DFCI TC1581318, TC1773079, TC1612484, TC1594599, TC1591323, TC1610172, TC1597598
DoTS DT.101732290, DT.94192105, DT.91597970, DT.87043950, DT.91319098, DT.91324775, DT.101364060, DT.91280793, DT.97360798, DT.101296728, DT.101341690
NIA Mouse Gene Index U035050, U015133
EC 3.1.4.53
Consensus CDS Project CCDS49331.1, CCDS49332.1
International Mouse Phenotyping Consortium Status Pde8b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000032523 VEGA Gene Model | MGI Sequence Detail 225883 C57BL/6J ±  kb
transcript OTTMUST00000093586 VEGA | MGI Sequence Detail 2598 Not Applicable 
polypeptide OTTMUSP00000051960 VEGA | MGI Sequence Detail 865 Not Applicable 

For the selected sequences
All sequences(141) RefSeq(32) UniProt(16)
Polymorphisms
SNPs within 2kb(1467 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR023088 3'5'-cyclic nucleotide phosphodiesterase
InterPro IPR002073 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
InterPro IPR023174 3'5'-cyclic nucleotide phosphodiesterase, conserved site
InterPro IPR013938 3'5'-cyclic nucleotide phosphodiesterase PDE8
InterPro IPR011006 CheY-like superfamily
InterPro IPR003607 HD/PDEase domain
InterPro IPR000014 PAS domain
InterPro IPR001789 Signal transduction response regulator, receiver domain
Protein Ontology PR:000012487 high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:203250 Tsai LC, et al., Inactivation of Pde8b enhances memory, motor performance, and protects against age-induced motor coordination decay. Genes Brain Behav. 2012 Oct;11(7):837-47
All references(34)
Other
accession IDs
MGI:1924861

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/23/2015
MGI 5.22
The Jackson Laboratory