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Pde8b Gene Detail
Summary
  • Symbol
    Pde8b
  • Name
    phosphodiesterase 8B
  • Synonyms
    B230331L10Rik, C030047E14Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443999
    NCBI Gene: 218461
  • Gene Overview
    MyGene.info: PDE8B
Location & Maps
more
  • Sequence Map
    Chr13:95024454-95250336 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      225883 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 49.22 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    PDE8B, phosphodiesterase 8B
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PDE8B, phosphodiesterase 8B
    Orthology source: HomoloGene
  • Synonyms
    ADSD, PPNAD3
  • Links
    NCBI Gene ID: 8622
    neXtProt AC: NX_O95263

  • Chr Location
    5q13.3; chr5:77180262-77428256 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    2 with human PDE8B associations

Human Disease Mouse Models
       Pigmented Nodular Adrenocortical Disease, Primary, 3; PPNAD3   OMIM: 614190
Striatal Degeneration, Autosomal Dominant 1; ADSD1   OMIM: 609161
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    4
  • Chemically induced (other)
    1
  • Gene trapped
    1
  • Targeted
    2
  • Genomic Mutations
    1 involving Pde8b
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit increased uring corticosterone, decreased serum adrenocorticotropin and decreased sensitivity to a PDE8-selective inhibitor.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000032523 VEGA Gene Model | MGI Sequence Detail 225883 C57BL/6J ±  kb
transcript OTTMUST00000093586 VEGA | MGI Sequence Detail 2598 Not Applicable  
polypeptide OTTMUSP00000051960 VEGA | MGI Sequence Detail 865 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    1465 from dbSNP Build 142
Protein
Information
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  • UniProt
    16 Sequences
  • Protein Ontology
    PR:000012487 high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B
  • EC
  • InterPro Domains
    IPR023088 3'5'-cyclic nucleotide phosphodiesterase
    IPR002073 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
    IPR023174 3'5'-cyclic nucleotide phosphodiesterase, conserved site
    IPR013938 3'5'-cyclic nucleotide phosphodiesterase PDE8
    IPR011006 CheY-like superfamily
    IPR003607 HD/PDEase domain
    IPR000014 PAS domain
Molecular
Reagents
less
  • All nucleic 32
    cDNA 32

    Microarray probesets 5
Other
Accession IDs
less
MGI:1924861
References
more
  • Summaries
    All 32
    Developmental Gene Expression 3
    Gene Ontology 6
    Phenotypes 8
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:203250 Tsai LC, et al., Inactivation of Pde8b enhances memory, motor performance, and protects against age-induced motor coordination decay. Genes Brain Behav. 2012 Oct;11(7):837-47

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory