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Pde8b
Gene Detail
Symbol

Name
ID
Pde8b
phosphodiesterase 8B
MGI:2443999
Synonyms
B230331L10Rik, C030047E14Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 13
49.22 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr13:95024454-95250336 bp, - strand
From VEGA annotation of GRCm38

  225883 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2758  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: 3',5'-cyclic-nucleotide phosphodiesterase 8A, high affinity cAMP-specific
Gene Tree: Pde8b

Human
homologs
Human Homolog PDE8B, phosphodiesterase 8B
NCBI Gene ID 8622
neXtProt AC  NX_O95263
Human Synonyms  ADSD, PPNAD3
Human Chr (Location)  5q13.3; chr5:77180257-77428256 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human PDE8B
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Gene trapped(1) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit increased uring corticosterone, decreased serum adrenocorticotropin and decreased sensitivity to a PDE8-selective inhibitor.
 
Interactions
Pde8b interacts with 254 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (3 records)
Data Summary: Results (230)    Tissues (163)    Images (34)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 230
cDNA source data(32)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(32) cDNA(32)
Microarray probesets(5)
Other database
links
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000032523 VEGA Gene Model | MGI Sequence Detail 225883 C57BL/6J ±  kb
transcript OTTMUST00000093586 VEGA | MGI Sequence Detail 2598 Not Applicable 
polypeptide OTTMUSP00000051960 VEGA | MGI Sequence Detail 865 Not Applicable 

For the selected sequences
All sequences(151) RefSeq(26) UniProt(32)
Polymorphisms
SNPs within 2kb(1467 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR023088 3'5'-cyclic nucleotide phosphodiesterase
InterPro IPR002073 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
InterPro IPR023174 3'5'-cyclic nucleotide phosphodiesterase, conserved site
InterPro IPR013938 3'5'-cyclic nucleotide phosphodiesterase PDE8
InterPro IPR011006 CheY-like superfamily
InterPro IPR003607 HD/PDEase domain
InterPro IPR000014 PAS domain
InterPro IPR001789 Signal transduction response regulator, receiver domain
Protein Ontology PR:000012487 high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:203250 Tsai LC, et al., Inactivation of Pde8b enhances memory, motor performance, and protects against age-induced motor coordination decay. Genes Brain Behav. 2012 Oct;11(7):837-47
All references(35)
Other
accession IDs
MGI:1924861

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory