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Cadps2 Gene Detail
Summary
  • Symbol
    Cadps2
  • Name
    Ca2+-dependent activator protein for secretion 2
  • Synonyms
    A230044C21Rik, Caps2, cpd2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443963
    NCBI Gene: 320405
  • Gene Overview
    MyGene.info: CADPS2
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:23262773-23839421 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 10.57 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3275 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443963
protein coding gene Chr6:23262773-23839421 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030488
protein coding gene Chr6:20799749-21401452 (-)
A/J MGP_AJ_G0030461
protein coding gene Chr6:19954247-20486267 (-)
AKR/J MGP_AKRJ_G0030388
protein coding gene Chr6:20603753-21149782 (-)
BALB/cJ MGP_BALBcJ_G0030471
protein coding gene Chr6:20040291-20583927 (-)
C3H/HeJ MGP_C3HHeJ_G0030184
protein coding gene Chr6:20547136-21149359 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030925
protein coding gene Chr6:21456191-22068298 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028136
protein coding gene Chr6:18478060-19012891 (-)
CAST/EiJ MGP_CASTEiJ_G0029586
protein coding gene Chr6:20473500-21028675 (-)
CBA/J MGP_CBAJ_G0030162
protein coding gene Chr6:22168877-22823375 (-)
DBA/2J MGP_DBA2J_G0030306
protein coding gene Chr6:19877195-20464746 (-)
FVB/NJ MGP_FVBNJ_G0030260
protein coding gene Chr6:19634733-20213860 (-)
LP/J MGP_LPJ_G0030393
protein coding gene Chr6:20936678-21531980 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030296
protein coding gene Chr6:24045784-24698430 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030955
protein coding gene Chr6:20545240-21110178 (-)
PWK/PhJ MGP_PWKPhJ_G0029300
protein coding gene Chr6:19496133-20043357 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029136
protein coding gene Chr6:20253383-20825414 (-)
WSB/EiJ MGP_WSBEiJ_G0029662
protein coding gene Chr6:20447687-21028981 (-)



Homology
more
  • Human Ortholog
    CADPS2, calcium dependent secretion activator 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CADPS2, calcium dependent secretion activator 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CAPS2
  • Links
    NCBI Gene ID: 93664
    neXtProt AC: NX_Q86UW7
    UniProt: Q86UW7

  • Chr Location
    7q31.32; chr7:122318424-122886759 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Cadps2 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    30 phenotypes from 2 alleles in 2 genetic backgrounds
    16 phenotypes from multigenic genotypes
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit defects in cerebellum, Purkinje cell and interneuron morphology, paired-pulse facilitation, and behaviors including emotional behavior, vestibuoocular reflex, circadium and sleep patterns, social investigation and nurturing behavior.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 320405 NCBI Gene Model | MGI Sequence Detail 576649 C57BL/6J ±  kb
    transcript NM_153163 RefSeq | MGI Sequence Detail 4969 C57BL/6  
    polypeptide Q8BYR5 UniProt | EBI | MGI Sequence Detail 1297 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      11 Sequences
    • InterPro Domains
      IPR033227 Calcium-dependent secretion activator
      IPR010439 Calcium-dependent secretion activator domain
      IPR014770 Munc13 homology 1
      IPR011993 PH-like domain superfamily
      IPR001849 Pleckstrin homology domain
    Molecular
    Reagents
    less
    • All nucleic 38
      cDNA 35
      Primer pair 3

      Microarray probesets 3
    References
    more
    • Summaries
      All 58
      Developmental Gene Expression 9
      Diseases 1
      Gene Ontology 11
      Phenotypes 23
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:261649 Shinoda Y, et al., Calcium-dependent activator protein for secretion 2 (CADPS2) deficiency causes abnormal synapse development in hippocampal mossy fiber terminals. Neurosci Lett. 2018 Apr 22;677:65-71

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/27/2018
    MGI 6.13
    The Jackson Laboratory