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Cadps2
Gene Detail
 Symbol
Name
ID
Cadps2
Ca2+-dependent activator protein for secretion 2
MGI:2443963
Synonyms A230044C21Rik, Caps2, cpd2
Feature Type protein coding gene
Genetic Map
Chromosome 6
10.57 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr6:23262773-23839420 bp, - strand
From VEGA annotation of GRCm38

  576648 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:23060  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Gene Tree: Cadps2

Human
homologs
Human Homolog CADPS2, Ca++-dependent secretion activator 2
NCBI Gene ID 93664
neXtProt AC  NX_Q86UW7
Human Chr (Location)  7q31.3; chr7:122318424-122886759 (-)  GRCh38
Alleles
and
phenotypes
All alleles(6) : Gene trapped(4) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit defects in cerebellum, Purkinje cell and interneuron morphology, paired-pulse facilitation, and behaviors including emotional behavior, vestibuoocular reflex, circadium and sleep patterns, social investigation and nurturing behavior.
 
Human Diseases Modeled Using Mouse Cadps2 (1)    Alleles Annotated to Human Diseases(1)   
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process cellular response to starvation, exocytosis, ...
Component cell junction, cytoplasmic membrane-bounded vesicle, ...
Function lipid binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (366)    Tissues (106)    Images (75)
Theiler Stages: 23, 24, 26, 28
Assay TypeResults
Immunohistochemistry 136
RNA in situ 190
Western blot 10
RT-PCR 30
cDNA source data(34)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(37) cDNA(34) Primer pair(3)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000022856 (Evidence)
Ensembl Gene ModelENSMUSG00000017978 (Evidence)
Entrez Gene320405 (Evidence)
UniGene259632
DFCITC1582295, TC1593298, TC1595787, TC1596158, TC1612785, TC1619883, TC1625115
DoTSDT.101124362, DT.101366715, DT.87047862, DT.91283315, DT.91421993, DT.91588032, DT.94267473, DT.99550327
NIA Mouse Gene IndexU006593, U027080
Consensus CDS ProjectCCDS39439.1, CCDS57411.1, CCDS57412.1, CCDS57413.1
International Mouse Knockout Project StatusCadps2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022856 VEGA Gene Model | MGI Sequence Detail 576648 C57BL/6J ±  kb
transcript OTTMUST00000055054 VEGA | MGI Sequence Detail 4723 Not Applicable 
polypeptide OTTMUSP00000026308 VEGA | MGI Sequence Detail 1304 Not Applicable 

For the selected sequences
All sequences(145) RefSeq(36) UniProt(11)
Polymorphisms SNPs within 2kb(3305 from dbSNP Build 137)    SNPs within 2kb including multiple locations(3313)
Protein-related
information
ResourceIDDescription
InterPro IPR000008 C2 calcium-dependent membrane targeting
InterPro IPR010439 Calcium-dependent secretion activator
InterPro IPR014770 Munc13 homology 1
InterPro IPR001849 Pleckstrin homology domain
InterPro IPR011993 Pleckstrin homology-like domain
Protein Ontology PR:000004965 calcium-dependent secretion activator 2
References (Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:205051 Miller JA, et al., Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates. Development. 2013 Nov;140(22):4633-44
All references(49)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory