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Aldh4a1
Gene Detail
 Symbol
Name
ID
Aldh4a1
aldehyde dehydrogenase 4 family, member A1
MGI:2443883
Synonyms A930035F14Rik, Ahd1, Ahd-1, ALDH4, P5CDH, Ssdh1
Feature Type protein coding gene
Genetic Map
Chromosome 4
70.79 cM
Detailed Genetic Map ± 1 cM


Mapping data(29)
Sequence Map
Chr4:139622866-139649690 bp, + strand
From VEGA annotation of GRCm38

  26825 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:6081  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: NAD-dependent aldehyde dehydrogenase
Gene Tree: Aldh4a1

Human
homologs
Human Homolog ALDH4A1, aldehyde dehydrogenase 4 family, member A1
NCBI Gene ID 8659
neXtProt AC  NX_P30038
Human Synonyms  ALDH4, P5CD, P5CDh
Human Chr (Location)  1p36; chr1:18871430-18902799 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human ALDH4A1
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from APF )
Interactions
Aldh4a1 interacts with 137 markers (Mir1a-1, Mir1a-2, Mir17, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process glutamate biosynthetic process, metabolic process, ...
Component mitochondrion
Function 1-pyrroline-5-carboxylate dehydrogenase activity, aldehyde dehydrogenase (NAD) activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (119)    Tissues (119)    Images (13)
Theiler Stages: 22, 26, 28
Assay TypeResults
RNA in situ 119
cDNA source data(168)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(169) cDNA(168) Primer pair(1)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000010054 (Evidence)
Ensembl Gene ModelENSMUSG00000028737 (Evidence)
Entrez Gene212647 (Evidence)
UniGene273571
DFCITC1574479, TC1608068
DoTSDT.101261049, DT.97410832
NIA Mouse Gene IndexU005019
EC1.2.1.3, 1.2.1.88
PDB3V9J, 3V9K, 3V9L, 4E3X, 4LGZ, 4LH0, 4LH1, 4LH2, 4LH3
Consensus CDS ProjectCCDS18848.1
International Mouse Knockout Project StatusAldh4a1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010054 VEGA Gene Model | MGI Sequence Detail 26825 C57BL/6J ±  kb
transcript OTTMUST00000023381 VEGA | MGI Sequence Detail 3382 Not Applicable 
polypeptide OTTMUSP00000010689 VEGA | MGI Sequence Detail 562 Not Applicable 

For the selected sequences
All sequences(39) RefSeq(4) UniProt(3)
Polymorphisms RFLP(1) : SNPs within 2kb(437 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005931 1-pyrroline-5-carboxylate dehydrogenase
InterPro IPR016160 Aldehyde dehydrogenase, conserved site
InterPro IPR016163 Aldehyde dehydrogenase, C-terminal
InterPro IPR015590 Aldehyde dehydrogenase domain
InterPro IPR016162 Aldehyde dehydrogenase, N-terminal
InterPro IPR016161 Aldehyde/histidinol dehydrogenase
Protein Ontology PR:000003928 delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial
References (Earliest) J:174 Holmes RS, Ahd. Mouse News Lett. 1978;58:45
(Latest) J:197778 Srivastava D, et al., The three-dimensional structural basis of type II hyperprolinemia. J Mol Biol. 2012 Jul 13;420(3):176-89
All references(61)
Other
accession IDs
MGD-MRK-1205, MGD-MRK-1212, MGD-MRK-16330, MGI:1353453, MGI:99552

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory