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Aldh4a1
Gene Detail
Symbol

Name
ID
Aldh4a1
aldehyde dehydrogenase 4 family, member A1
MGI:2443883
Synonyms
A930035F14Rik, Ahd1, Ahd-1, ALDH4, P5CDH, Ssdh1
Feature Type
protein coding gene
Genetic Map
Chromosome 4
70.79 cM
Detailed Genetic Map ± 1 cM


Mapping data(29)
Sequence Map
Chr4:139622866-139649690 bp, + strand
From VEGA annotation of GRCm38

  26825 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:6081  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ALDH4A1
Protein SuperFamily: NAD-dependent aldehyde dehydrogenase
Gene Tree: Aldh4a1

Human
homologs
ALDH4A1, aldehyde dehydrogenase 4 family, member A1
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 8659
neXtProt AC: NX_P30038

Human Synonyms: ALDH4, P5CD, P5CDh

Human Chr (Location): 1p36; chr1:18871430-18902799 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human ALDH4A1

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Genomic Mutations involving Aldh4a1 (1)
Incidental mutations (data from APF )
Interactions
Aldh4a1 interacts with 136 markers (Mir1a-1, Mir1a-2, Mir17, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process glutamate biosynthetic process, metabolic process, ...
Component mitochondrion
Function 1-pyrroline-5-carboxylate dehydrogenase activity, aldehyde dehydrogenase (NAD) activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (119)    Tissues (119)    Images (13)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 119
cDNA source data(168)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA ALDH4A1 ; Xenbase aldh4a1 ; ZFIN aldh4a1    NEW 
Molecular
reagents
All nucleic(169) cDNA(168) Primer pair(1)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000010054 (Evidence)
Ensembl Gene Model ENSMUSG00000028737 (Evidence)
Entrez Gene 212647 (Evidence)
UniGene 273571
DFCI TC1608068, TC1574479
DoTS DT.97410832, DT.101261049
NIA Mouse Gene Index U005019
EC 1.2.1.3, 1.2.1.88
PDB 3V9L, 4E3X, 3V9J, 3V9K, 4LGZ, 4LH0, 4LH3, 4LH2, 4LH1
Consensus CDS Project CCDS18848.1
International Mouse Phenotyping Consortium Status Aldh4a1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010054 VEGA Gene Model | MGI Sequence Detail 26825 C57BL/6J ±  kb
transcript OTTMUST00000023381 VEGA | MGI Sequence Detail 3382 Not Applicable 
polypeptide OTTMUSP00000010689 VEGA | MGI Sequence Detail 562 Not Applicable 

For the selected sequences
All sequences(42) RefSeq(6) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(437 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005931 1-pyrroline-5-carboxylate dehydrogenase
InterPro IPR016160 Aldehyde dehydrogenase, conserved site
InterPro IPR016163 Aldehyde dehydrogenase, C-terminal
InterPro IPR015590 Aldehyde dehydrogenase domain
InterPro IPR016162 Aldehyde dehydrogenase, N-terminal
InterPro IPR016161 Aldehyde/histidinol dehydrogenase
Protein Ontology PR:000003928 delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial
References
(Earliest) J:174 Holmes RS, Ahd. Mouse News Lett. 1978;58:45
(Latest) J:206680 Pemberton TA, et al., Structural basis of substrate selectivity of Delta(1)-pyrroline-5-carboxylate dehydrogenase (ALDH4A1): semialdehyde chain length. Arch Biochem Biophys. 2013 Oct 1;538(1):34-40
All references(60)
Other
accession IDs
MGD-MRK-1205, MGD-MRK-1212, MGD-MRK-16330, MGI:1353453, MGI:99552

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory