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Gene Detail
solute carrier family 4, sodium bicarbonate cotransporter, member 7
Synonyms E430014N10Rik, NBC3, NBCn1
Feature Type protein coding gene
Genetic Map
Chromosome 14
7.08 cM
Detailed Genetic Map ± 1 cM

Mapping data(1)
Sequence Map
Chr14:14703025-14799943 bp, + strand
From NCBI annotation of GRCm38

  96919 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
HomoloGene:2680  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: band 3-like protein
Gene Tree: Slc4a7

Human Homolog SLC4A7, solute carrier family 4, sodium bicarbonate cotransporter, member 7
NCBI Gene ID 9497
neXtProt AC  NX_Q9Y6M7
Human Synonyms  NBC2, NBC3, NBCN1, SBC2, SLC4A6
Human Chr (Location)  3p22; chr3:27372721-27484420 (-)  GRCh38
alleles, and
All mutations/alleles(16) : Gene trapped(12) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
Mice homozygous for a disruption at this locus display defects of the auditory and visual systems similar to those observed in patients with Ushers syndrome. Mice homozygous for a gene trap allele exhibit disruption in sodium/bicarbonate function that impacts vasodilation and hypertension.
Human Diseases Modeled Using Mouse Slc4a7 (1)    Alleles Annotated to Human Diseases(1)   
Slc4a7 interacts with 438 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
All GO classifications: (29 annotations)
Process anion transport, auditory receptor cell development, ...
Component apical plasma membrane, basolateral plasma membrane, ...
Function anion transmembrane transporter activity, inorganic anion exchanger activity, ...
External Resources: FuncBase
Literature Summary: (1 records)
cDNA source data(96)
External Resources: Allen Institute   GEO   Expression Atlas
All nucleic(99) cDNA(96) Primer pair(1) Other(2)
Microarray probesets(4)
Other database
Ensembl Gene ModelENSMUSG00000021733 (Evidence)
Entrez Gene218756 (Evidence)
DFCITC1583195, TC1603101, TC1620500, TC1622978, TC1637551
DoTSDT.101382067, DT.103570738, DT.110748956, DT.483664, DT.529055, DT.91329681, DT.94239425
NIA Mouse Gene IndexU015326
Consensus CDS ProjectCCDS36810.1
International Mouse Knockout Project StatusSlc4a7
Representative SequencesLengthStrain/SpeciesFlank
genomic 218756 NCBI Gene Model | MGI Sequence Detail 96919 C57BL/6J ±  kb
transcript NM_001033270 RefSeq | MGI Sequence Detail 7389 Not Specified 
polypeptide Q8BTY2 UniProt | EBI | MGI Sequence Detail 1034 Not Applicable 

For the selected sequences
All sequences(84) RefSeq(16) UniProt(21)
Polymorphisms SNPs within 2kb(680 from dbSNP Build 137)    SNPs within 2kb including multiple locations(692)
InterPro IPR013769 Band 3 cytoplasmic domain
InterPro IPR011531 Bicarbonate transporter, C-terminal
InterPro IPR003020 Bicarbonate transporter, eukaryotic
InterPro IPR016152 Phosphotransferase/anion transporter
InterPro IPR003024 Sodium bicarbonate cotransporter
Protein Ontology PR:000015162 sodium bicarbonate cotransporter 3
Graphical View of Protein Domain Structure
References (Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:208247 Singh AK, et al., Essential role of the electroneutral Na+-HCO3- cotransporter NBCn1 in murine duodenal acid-base balance and colonic mucus layer build-up in vivo. J Physiol. 2013 Apr 15;591(Pt 8):2189-204
All references(46)
Disease annotation references (1)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 5.19
The Jackson Laboratory