Slc4a7
Gene Detail

Symbol Name ID

Slc4a7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 MGI:2443878

Synonyms

E430014N10Rik, NBC3, NBCn1

Feature Type

protein coding gene

Genetic Map

Chromosome 14

7.08 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr14:14703025-14799943 bp, + strand From NCBI annotation of GRCm38   96919 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:2680  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: band 3-like protein
Gene Tree: Slc4a7

Human homologs

Human Homolog		SLC4A7, solute carrier family 4, sodium bicarbonate cotransporter, member 7
NCBI Gene ID		9497
neXtProt AC		NX_Q9Y6M7
Human Synonyms		NBC2, NBC3, NBCN1, SBC2, SLC4A6
Human Chr (Location)		3p22; chr3:27414212-27525911 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(16) : Targeted(4) Gene trapped(12)
 

Mice homozygous for a disruption at this locus display defects of the auditory and visual systems similar to those observed in patients with Ushers syndrome. Mice homozygous for a gene trap allele exhibit disruption in sodium/bicarbonate function that impacts vasodilation and hypertension.

 
Human Diseases Modeled Using Mouse Slc4a7 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (27 annotations)

Process	anion transport, auditory receptor cell development, ...
Component	apical plasma membrane, basolateral plasma membrane, ...
Function	anion transmembrane transporter activity, inorganic anion exchanger activity, ...

External Resources: FuncBase

Expression

Literature Summary: (1 records)
cDNA source data(8)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(11) cDNA(8) Primer pair(1) Other(2)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000021733 (Evidence)
Entrez Gene	218756 (Evidence)
DFCI	TC1583195, TC1603101, TC1620500, TC1622978, TC1637551
DoTS	DT.101382067, DT.103570738, DT.110748956, DT.483664, DT.529055, DT.91329681, DT.94239425
NIA Mouse Gene Index	U015326
Consensus CDS Project	CCDS36810.1
International Mouse Knockout Project Status	Slc4a7

Sequences

Length	Strain/Species
genomic	218756	NCBI Gene Model | MGI Sequence Detail	96919	C57BL/6J
transcript	NM_001033270	RefSeq | MGI Sequence Detail	7389	Not Specified
polypeptide	Q8BTY2	UniProt | EBI | MGI Sequence Detail	1034	Not Applicable

All sequences(56) RefSeq(2) UniProt(14)

Polymorphisms

SNPs(535 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR011531	Bicarbonate transporter, C-terminal
InterPro	IPR013769	Bicarbonate transporter, cytoplasmic
InterPro	IPR003020	Bicarbonate transporter, eukaryotic
InterPro	IPR016152	Phosphotransferase/anion transporter
InterPro	IPR003024	Sodium bicarbonate cotransporter
Protein Ontology	PR:000015162	sodium bicarbonate cotransporter 3

Graphical View of Protein Domain Structure

References

(Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:189470 Boedtkjer E, et al., Disruption of Na+,HCO(3)(-) cotransporter NBCn1 (slc4a7) inhibits NO-mediated vasorelaxation, smooth muscle Ca(2)(+) sensitivity, and hypertension development in mice. Circulation. 2011 Oct 25;124(17):1819-29
All references(42)