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Slc4a7
Gene Detail
Symbol

Name
ID
Slc4a7
solute carrier family 4, sodium bicarbonate cotransporter, member 7
MGI:2443878
Synonyms
E430014N10Rik, NBC3, NBCn1
Feature Type
protein coding gene
Genetic Map
Chromosome 14
7.08 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr14:14703025-14799943 bp, + strand
From Ensembl annotation of GRCm38

  96919 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2680  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: band 3-like protein
Gene Tree: Slc4a7

Human
homologs
Human Homolog SLC4A7, solute carrier family 4, sodium bicarbonate cotransporter, member 7
NCBI Gene ID 9497
neXtProt AC  NX_Q9Y6M7
Human Synonyms  NBC2, NBC3, NBCN1, SBC2, SLC4A6
Human Chr (Location)  3p22; chr3:27372721-27484420 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(16) : Gene trapped(12) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a disruption at this locus display defects of the auditory and visual systems similar to those observed in patients with Ushers syndrome. Mice homozygous for a gene trap allele exhibit disruption in sodium/bicarbonate function that impacts vasodilation and hypertension.
 
Human Diseases Modeled Using Mouse Slc4a7 (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Slc4a7 interacts with 438 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (1 records)
cDNA source data(96)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(99) cDNA(96) Primer pair(1) Other(2)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000021733 (Evidence)
Entrez Gene218756 (Evidence)
UniGene258893
DFCITC1620500, TC1637551, TC1622978, TC1583195, TC1603101
DoTSDT.91329681, DT.483664, DT.529055, DT.110748956, DT.103570738, DT.101382067, DT.94239425
NIA Mouse Gene IndexU015326
Consensus CDS ProjectCCDS36810.1
International Mouse Knockout Project StatusSlc4a7
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000021733 Ensembl Gene Model | MGI Sequence Detail 96919 C57BL/6J ±  kb
transcript ENSMUST00000057015 Ensembl | MGI Sequence Detail 7389 Not Applicable 
polypeptide ENSMUSP00000058313 Ensembl | MGI Sequence Detail 1131 Not Applicable 

For the selected sequences
All sequences(104) RefSeq(16) UniProt(41)
Polymorphisms
SNPs within 2kb(680 from dbSNP Build 137)    SNPs within 2kb including multiple locations(692)
Protein-related
information
ResourceIDDescription
InterPro IPR013769 Band 3 cytoplasmic domain
InterPro IPR011531 Bicarbonate transporter, C-terminal
InterPro IPR003020 Bicarbonate transporter, eukaryotic
InterPro IPR016152 Phosphotransferase/anion transporter
InterPro IPR003024 Sodium bicarbonate cotransporter
Protein Ontology PR:000015162 sodium bicarbonate cotransporter 3
References
(Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:208247 Singh AK, et al., Essential role of the electroneutral Na+-HCO3- cotransporter NBCn1 in murine duodenal acid-base balance and colonic mucus layer build-up in vivo. J Physiol. 2013 Apr 15;591(Pt 8):2189-204
All references(47)
Disease annotation references (1)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory