Ppfia2 MGI Mouse Gene Detail - MGI:2443834 - protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2

Symbol

Ppfia2
Name

protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
Synonyms

E130120L08Rik, Liprin-alpha2

Feature Type

protein coding gene
IDs

MGI:2443834
NCBI Gene: 327814
Alliance

gene page
Transcription Start Sites

13 TSS

Sequence Map

Chr10:106305129-106769329 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 55.39 cM
Mapping Data

2 experiments

SNPs within 2kb

15887 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2443834	protein coding gene	Chr10:106305129-106771813 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017705	protein coding gene	Chr10:108568888-109081788 (+)
A/J	MGP_AJ_G0017682	protein coding gene	Chr10:104542845-105017921 (+)
AKR/J	MGP_AKRJ_G0017644	protein coding gene	Chr10:107608767-108080179 (+)
BALB/cJ	MGP_BALBcJ_G0017646	protein coding gene	Chr10:104931365-105400913 (+)
C3H/HeJ	MGP_C3HHeJ_G0017471	protein coding gene	Chr10:107677131-108160889 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018103	protein coding gene	Chr10:112378153-112881868 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015782	protein coding gene	Chr10:99509209-99969719 (+)
CAST/EiJ	MGP_CASTEiJ_G0017032	protein coding gene	Chr10:107749680-108257073 (+)
CBA/J	MGP_CBAJ_G0017440	protein coding gene	Chr10:116733068-117255525 (+)
DBA/2J	MGP_DBA2J_G0017545	protein coding gene	Chr10:103679357-104154094 (+)
FVB/NJ	MGP_FVBNJ_G0017539	protein coding gene	Chr10:102702902-103172856 (+)
LP/J	MGP_LPJ_G0017619	protein coding gene	Chr10:109233580-109712982 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017569	protein coding gene	Chr10:119084972-119726915 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018141	protein coding gene	Chr10:107567649-108050208 (+)
PWK/PhJ	MGP_PWKPhJ_G0016814	protein coding gene	Chr10:103718658-104216299 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016604	protein coding gene	Chr10:106327766-106804250 (+)
WSB/EiJ	MGP_WSBEiJ_G0017092	protein coding gene	Chr10:107666136-108164160 (+)

Human Ortholog

PPFIA2, PPFI scaffold protein A2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PPFIA2, PPFI scaffold protein A2
Links

HGNC:9246

NCBI Gene ID: 8499

UniProt: O75334
Chr Location

12q21.31; chr12:81257975-81759553 (-) GRCh38

MGI Vertebrate Homology

Ppfia2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PPFIA2
Gene Tree

Ppfia2

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Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (other)

1
Endonuclease-mediated

4
Gene trapped

1
Targeted

4
Genomic Mutations

1 involving Ppfia2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

83 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

34
GO References

13

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

778
Tissues

41
cDNA Data

31
Literature Summary

7

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ppfia2

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All Sequences

184
RefSeq

144
UniProt

4
CCDS

CCDS56746.1, CCDS88082.1

Ensembl

ENSMUSG00000053825 (Evidence)
NCBI Gene

327814

			Length	Strain/Species	Flank
genomic	327814	NCBI Gene Model \| MGI Sequence Detail	464201	C57BL/6J	± kb
transcript	NM_001359672	RefSeq \| MGI Sequence Detail	6463	C57BL/6
polypeptide	Q8BSS9	UniProt \| EBI \| MGI Sequence Detail	1257	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000013069 liprin-alpha-2

(term hierarchy)
InterPro Domains

IPR029515 LAR-interacting protein, Liprin

IPR037620 Liprin-alpha, SAM domain repeat 1

IPR037621 Liprin-alpha, SAM domain repeat 2

IPR037622 Liprin-alpha, SAM domain repeat 3

IPR001660 Sterile alpha motif domain

IPR013761 Sterile alpha motif/pointed domain superfamily
GlyGen

Q8BSS9 9 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (7 sites)

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All nucleic 38

Genomic 2

cDNA 31

Primer pair 5

Microarray probesets 3

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MGI:2445215

Summaries

All 51

Developmental Gene Expression 7

Gene Ontology 13

Phenotypes 16
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:358058 Emperador-Melero J, et al., Distinct active zone protein machineries mediate Ca(2+) channel clustering and vesicle priming at hippocampal synapses. Nat Neurosci. 2024 Sep;27(9):1680-1694

TSS for Ppfia2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr95624	Chr10:106306142-106306228 (+)	1,056 bp
Tssr95625	Chr10:106332727-106332731 (+)	27,600 bp
Tssr95626	Chr10:106451641-106451656 (+)	146,520 bp
Tssr95627	Chr10:106468259-106468303 (+)	163,152 bp
Tssr95628	Chr10:106468547-106468559 (+)	163,424 bp
Tssr95629	Chr10:106468612-106468674 (+)	163,514 bp
Tssr95630	Chr10:106474250-106474278 (+)	169,135 bp
Tssr95631	Chr10:106511674-106511675 (+)	206,546 bp
Tssr3344	Chr10:106559472-106559474 (+)	254,344 bp
Tssr95637	Chr10:106715676-106715693 (+)	410,556 bp
Tssr95638	Chr10:106715732-106715762 (+)	410,618 bp
Tssr95639	Chr10:106715818-106715829 (+)	410,695 bp
Tssr95640	Chr10:106715855-106715867 (+)	410,732 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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