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Snx8 Gene Detail
Summary
  • Symbol
    Snx8
  • Name
    sorting nexin 8
  • Synonyms
    B130023O14Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443816
    NCBI Gene: 231834
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:140340299-140389262 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 78.95 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    7 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443816
protein coding gene Chr5:140340293-140389308 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030298
protein coding gene Chr5:145400251-145454932 (-)
A/J MGP_AJ_G0030267
protein coding gene Chr5:139216253-139270253 (-)
AKR/J MGP_AKRJ_G0030199
protein coding gene Chr5:143563111-143616178 (-)
BALB/cJ MGP_BALBcJ_G0030284
protein coding gene Chr5:140461170-140510895 (-)
C3H/HeJ MGP_C3HHeJ_G0029995
protein coding gene Chr5:144340318-144394254 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030729
protein coding gene Chr5:150787441-150844108 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027947
protein coding gene Chr5:133063254-133113844 (-)
CAST/EiJ MGP_CASTEiJ_G0029400
protein coding gene Chr5:143773409-143824805 (-)
CBA/J MGP_CBAJ_G0029965
protein coding gene Chr5:156975448-157038699 (-)
DBA/2J MGP_DBA2J_G0030115
protein coding gene Chr5:139028801-139079120 (-)
FVB/NJ MGP_FVBNJ_G0030070
protein coding gene Chr5:138171514-138223680 (-)
LP/J MGP_LPJ_G0030201
protein coding gene Chr5:146014773-146065685 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030101
protein coding gene Chr5:159571063-159628335 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030769
protein coding gene Chr5:143395147-143451386 (-)
PWK/PhJ MGP_PWKPhJ_G0029115
protein coding gene Chr5:138050515-138102627 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028951
protein coding gene Chr5:141094463-141153833 (-)
WSB/EiJ MGP_WSBEiJ_G0029474
protein coding gene Chr5:144179731-144233426 (-)



Homology
more
  • Human Ortholog
    SNX8, sorting nexin 8
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SNX8, sorting nexin 8
    Orthology source: HomoloGene, HGNC
  • Synonyms
    Mvp1
  • Links
    NCBI Gene ID: 29886
    neXtProt AC: NX_Q9Y5X2
    UniProt: Q9Y5X2

  • Chr Location
    7p22.3; chr7:2251770-2354481 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 8338
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: SNX8
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000029560 Ensembl Gene Model | MGI Sequence Detail 48964 C57BL/6J ±  kb
transcript ENSMUST00000031539 Ensembl | MGI Sequence Detail 2627 Not Applicable  
polypeptide ENSMUSP00000031539 Ensembl | MGI Sequence Detail 459 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 46
    cDNA 46

    Microarray probesets 3
References
more
  • Summaries
    All 29
    Developmental Gene Expression 1
    Gene Ontology 3
    Phenotypes 9
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:254306 Wei J, et al., SNX8 mediates IFNgamma-triggered noncanonical signaling pathway and host defense against Listeria monocytogenes. Proc Natl Acad Sci U S A. 2017 Dec 5;114(49):13000-13005

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
12/03/2019
MGI 6.14
The Jackson Laboratory