About   Help   FAQ
Iqcb1 Gene Detail
Summary
  • Symbol
    Iqcb1
  • Name
    IQ calmodulin-binding motif containing 1
  • Synonyms
    6820449I09Rik, NPHP5
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443764
    NCBI Gene: 320299
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:36648747-36693083 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 26.11 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    717 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443764
 protein coding gene Chr16:36648722-36694044 (+)
129S1/SvImJ ENSMUSG00200029012
 protein coding gene Chr16:33584368-33629911 (+)
A/J ENSMUSG00195010132
 protein coding gene Chr16:33130806-33176350 (+)
AKR/J ENSMUSG00220027928
 protein coding gene Chr16:33508485-33553989 (+)
BALB/cJ ENSMUSG00180012477
 protein coding gene Chr16:33346416-33391958 (+)
C3H/HeJ ENSMUSG00175031283
 protein coding gene Chr16:33566795-33612327 (+)
C57BL/6NJ ENSMUSG00215017739
 protein coding gene Chr16:33419959-33465500 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020721
 protein coding gene Chr16:33872636-33918808 (+)
CAST/EiJ ENSTCUG00005031187
 protein coding gene Chr16:33838889-33884442 (+)
CBA/J ENSMUSG00210026750
 protein coding gene Chr16:33623873-33669410 (+)
DBA/2J ENSMUSG00185022531
 protein coding gene Chr16:33526910-33572440 (+)
FVB/NJ ENSMUSG00205020792
 protein coding gene Chr16:33483862-33529365 (+)
JF1/MsJ ENSUMUG00000017015
 protein coding gene Chr16:33747807-33792146 (+)
LP/J ENSMUSG00230025943
 protein coding gene Chr16:36099107-36144639 (+)
NOD/ShiLtJ ENSMUSG00190022098
 protein coding gene Chr16:33645300-33690789 (+)
NZO/HlLtJ ENSMUSG00225039426
 protein coding gene Chr16:39198470-39244004 (+)
PWK/PhJ ENSLUMG00010029095
 protein coding gene Chr16:33655128-33699951 (+)
SPRET/EiJ ENSMSPG00010016605
 protein coding gene Chr16:33626702-33672037 (+)
WSB/EiJ ENSIUOG00005024202
 protein coding gene Chr16:33696686-33740957 (+)



Homology
more
  • Human Ortholog
    IQCB1, IQ motif containing B1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IQCB1, IQ motif containing B1
  • Synonyms
    NPHP5, PIQ, SLSN5
  • Links
    NCBI Gene ID: 9657
    UniProt: Q15051

  • Chr Location
    3q13.33; chr3:121769399-121835093 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Iqcb1 mouse models; 4 with human IQCB1 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotypes from 2 alleles in 3 genetic backgrounds
    4 phenotypes from multigenic genotypes
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice show absence of scotopic and photopic responses indicating early blindness, photoreceptor degeneration and impaired outer segment formation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    39
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    635
  • Tissues
    12
  • cDNA Data
    43
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022837 Ensembl Gene Model | MGI Sequence Detail 44337 C57BL/6J ±  kb
    transcript ENSMUST00000023535 Ensembl | MGI Sequence Detail 2257 Not Applicable  
    polypeptide ENSMUSP00000023535 Ensembl | MGI Sequence Detail 598 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000031856 IQ calmodulin-binding motif-containing protein 1
      (term hierarchy)
    • InterPro Domains
      IPR016024 Armadillo-type fold
      IPR028765 IQ calmodulin-binding motif-containing protein 1
      IPR000048 IQ motif, EF-hand binding site
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
    Molecular
    Reagents
    less
    • All nucleic 43
      cDNA 43
      Antibodies 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2146598
    References
    more
    • Summaries
      All 41
      Developmental Gene Expression 3
      Diseases 1
      Gene Ontology 8
      Phenotypes 13
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory