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Iqcb1
Gene Detail
Symbol

Name
ID
Iqcb1
IQ calmodulin-binding motif containing 1
MGI:2443764
Synonyms
6820449I09Rik, NPHP5
Feature Type
protein coding gene
Genetic Map
Chromosome 16
26.11 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr16:36828385-36872721 bp, + strand
From VEGA annotation of GRCm38

  44337 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8766  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: IQCB1
Gene Tree: Iqcb1

Human
homologs
IQCB1, IQ motif containing B1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 9657
neXtProt AC: NX_Q15051

Human Synonyms: NPHP5, PIQ, SLSN5

Human Chr (Location): 3q13.33; chr3:121769763-121835079 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human IQCB1

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(3) Targeted(2)
Incidental mutations (data from Mutagenetix , APF , CvDC )
Interactions
Iqcb1 interacts with 190 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process cilium assembly, maintenance of organ identity, ...
Component centrosome, cytoplasm, ...
Function calmodulin binding, enzyme binding, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (38)    Tissues (12)    Images (28)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 4
RNA in situ 30
Western blot 4
cDNA source data(41)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase iqcb1    NEW 
Molecular
reagents
All nucleic(41) cDNA(41)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000024358 (Evidence)
Ensembl Gene Model ENSMUSG00000022837 (Evidence)
Entrez Gene 320299 (Evidence)
UniGene 222934
DFCI TC1579019, TC1589901, TC1624890
DoTS DT.91587535, DT.99839381, DT.55223853, DT.485387
NIA Mouse Gene Index U017079
Consensus CDS Project CCDS28157.1
International Mouse Phenotyping Consortium Status Iqcb1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024358 VEGA Gene Model | MGI Sequence Detail 44337 C57BL/6J ±  kb
transcript OTTMUST00000059670 VEGA | MGI Sequence Detail 2257 Not Applicable 
polypeptide OTTMUSP00000029045 VEGA | MGI Sequence Detail 598 Not Applicable 

For the selected sequences
All sequences(51) RefSeq(10) UniProt(1)
Polymorphisms
SNPs within 2kb(43 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016024 Armadillo-type fold
InterPro IPR000048 IQ motif, EF-hand binding site
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000031856 IQ calmodulin-binding motif-containing protein 1
References
(Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:173396 Sang L, et al., Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways. Cell. 2011 May 13;145(4):513-28
All references(29)
Other
accession IDs
MGI:2146598

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory