About   Help   FAQ
Iqcb1 Gene Detail
Summary
  • Symbol
    Iqcb1
  • Name
    IQ calmodulin-binding motif containing 1
  • Synonyms
    6820449I09Rik, NPHP5
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443764
    NCBI Gene: 320299
  • Gene Overview
    MyGene.info: IQCB1
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:36828385-36872721 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 26.11 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    41 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443764
protein coding gene Chr16:36828360-36872721 (.)
129S1/SvImJ MGP_129S1SvImJ_G0022794
protein coding gene Chr16:35240703-35294219 (+)
A/J MGP_AJ_G0022759
protein coding gene Chr16:33508383-33553478 (+)
AKR/J MGP_AKRJ_G0022731
protein coding gene Chr16:34792801-34837084 (+)
BALB/cJ MGP_BALBcJ_G0022760
protein coding gene Chr16:33611576-33657067 (+)
C3H/HeJ MGP_C3HHeJ_G0022524
protein coding gene Chr16:34901985-34954019 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023207
protein coding gene Chr16:36089100-36137100 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020721
protein coding gene Chr16:33872636-33918808 (+)
CAST/EiJ MGP_CASTEiJ_G0022050
protein coding gene Chr16:35026493-35074688 (+)
CBA/J MGP_CBAJ_G0022495
protein coding gene Chr16:37666030-37716436 (+)
DBA/2J MGP_DBA2J_G0022627
protein coding gene Chr16:33400550-33449060 (+)
FVB/NJ MGP_FVBNJ_G0022602
protein coding gene Chr16:33435181-33479276 (+)
LP/J MGP_LPJ_G0022695
protein coding gene Chr16:34952683-35000295 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022621
protein coding gene Chr16:36690815-36772961 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023222
protein coding gene Chr16:34735199-34785318 (+)
PWK/PhJ MGP_PWKPhJ_G0021790
protein coding gene Chr16:33802444-33849316 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021621
protein coding gene Chr16:34652843-34701991 (+)
WSB/EiJ MGP_WSBEiJ_G0022094
protein coding gene Chr16:34793524-34842516 (+)



Homology
more
  • Human Ortholog
    IQCB1, IQ motif containing B1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    IQCB1, IQ motif containing B1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    NPHP5, PIQ, SLSN5
  • Links
    NCBI Gene ID: 9657
    neXtProt AC: NX_Q15051
    UniProt: Q15051

  • Chr Location
    3q13.33; chr3:121769761-121835079 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human IQCB1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022837 Ensembl Gene Model | MGI Sequence Detail 44337 C57BL/6J ±  kb
transcript ENSMUST00000023535 Ensembl | MGI Sequence Detail 2257 Not Applicable  
polypeptide ENSMUSP00000023535 Ensembl | MGI Sequence Detail 598 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000031856 IQ calmodulin-binding motif-containing protein 1
  • InterPro Domains
    IPR016024 Armadillo-type fold
    IPR028765 IQ calmodulin-binding motif-containing protein 1
    IPR000048 IQ motif, EF-hand binding site
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
Molecular
Reagents
less
  • All nucleic 43
    cDNA 43

    Microarray probesets 4
Other
Accession IDs
less
MGI:2146598
References
more
  • Summaries
    All 28
    Developmental Gene Expression 3
    Gene Ontology 4
    Phenotypes 4
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:239714 Ronquillo CC, et al., Ciliopathy-associated IQCB1/NPHP5 protein is required for mouse photoreceptor outer segment formation. FASEB J. 2016 Oct;30(10):3400-3412

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/06/2018
MGI 6.13
The Jackson Laboratory