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Intu
Gene Detail
Symbol

Name
ID
Intu
inturned planar cell polarity effector homolog (Drosophila)
MGI:2443752
Synonyms
9230116I04Rik, 9430087H23Rik, mKIAA1284, Pdzd6, Pdzk6
Feature Type
protein coding gene
Genetic Map
Chromosome 3
19.46 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr3:40531286-40704774 bp, + strand
From VEGA annotation of GRCm38

  173489 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:41059  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Intu

Human
homologs
Human Homolog INTU, inturned planar cell polarity protein
NCBI Gene ID 27152
neXtProt AC  NX_Q9ULD6
Human Synonyms  INT, PDZD6, PDZK6
Human Chr (Location)  4q28.1; chr4:127632932-127716779 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit abnormal neural tube development, polydactyly, and die by E16.5.
 
Interactions
Intu interacts with 360 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process cell projection organization, cilium assembly, ...
Component cytoplasm
Function molecular_function
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (43)    Tissues (29)    Images (13)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 43
cDNA source data(5)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(5) cDNA(5)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000030600 (Evidence)
Ensembl Gene ModelENSMUSG00000060798 (Evidence)
Entrez Gene380614 (Evidence)
DFCITC1626467, TC1686568, TC1592262
DoTSDT.55152875, DT.91296983
NIA Mouse Gene IndexU003184
International Mouse Knockout Project StatusIntu
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030600 VEGA Gene Model | MGI Sequence Detail 173489 C57BL/6J ±  kb
transcript OTTMUST00000075785 VEGA | MGI Sequence Detail 6387 Not Applicable 
polypeptide OTTMUSP00000039792 VEGA | MGI Sequence Detail 942 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(470 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001478 PDZ domain
Protein Ontology PR:000030497 protein inturned
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:205544 Dai D, et al., Planar cell polarity effector gene Intu regulates cell fate-specific differentiation of keratinocytes through the primary cilia. Cell Death Differ. 2013 Jan;20(1):130-8
All references(28)
Other
accession IDs
MGI:1925153

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/11/2014
MGI 5.20
The Jackson Laboratory