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Intu Gene Detail
Summary
  • Symbol
    Intu
  • Name
    inturned planar cell polarity protein
  • Synonyms
    9230116I04Rik, 9430087H23Rik, mKIAA1284, Pdzd6, Pdzk6
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443752
    NCBI Gene: 380614
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr3:40531286-40704774 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      173489 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 19.46 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    INTU, inturned planar cell polarity protein
  • Vertebrate Orthologs
    9
  • Human Ortholog
    INTU, inturned planar cell polarity protein
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CPLANE4, INT, OFD17, PDZD6, PDZK6, SRTD20
  • Links
    NCBI Gene ID: 27152
    neXtProt AC: NX_Q9ULD6
    UniProt: Q9ULD6

  • Chr Location
    4q28.1; chr4:127623271-127716779 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 41059
    1 human;1 mouse;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: INTU
  • Gene Tree
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    39 phenotypes from 3 alleles in 3 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice show defective ciliogenesis and neural tube closure, abnormal patterning of the CNS and limbs, polydactyly, edema and death by E16.5. Homozygotes for a hypomorphic allele show defective ciliation and endochondral ossification, stunted growth, polydactyly and postnatal lethality.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000030600 VEGA Gene Model | MGI Sequence Detail 173489 C57BL/6J ±  kb
    transcript OTTMUST00000075785 VEGA | MGI Sequence Detail 6387 Not Applicable  
    polypeptide OTTMUSP00000039792 VEGA | MGI Sequence Detail 942 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      470 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 5
      cDNA 5

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1925153
    References
    more
    • Summaries
      All 32
      Developmental Gene Expression 3
      Diseases 1
      Gene Ontology 6
      Phenotypes 10
    • Earliest
      J:64276 Lyon MF, et al., Dose-response curves for radiation-induced gene mutations in mouse oocytes and their interpretation. Mutat Res. 1979 Nov;63(1):161-73
    • Latest
      J:222441 Chang R, et al., A hypomorphic allele reveals an important role of inturned in mouse skeletal development. Dev Dyn. 2015 Jun;244(6):736-47

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory