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Intu
Gene Detail
Symbol

Name
ID
Intu
inturned planar cell polarity effector homolog (Drosophila)
MGI:2443752
Synonyms
9230116I04Rik, 9430087H23Rik, mKIAA1284, Pdzd6, Pdzk6
Feature Type
protein coding gene
Genetic Map
Chromosome 3
19.46 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr3:40653702-40704774 bp, + strand
From NCBI annotation of GRCm38

  51073 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:41059  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: INTU
Gene Tree: Intu

Human
homologs
INTU, inturned planar cell polarity protein
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 27152
neXtProt AC: NX_Q9ULD6

Human Synonyms: INT, PDZD6, PDZK6

Human Chr (Location): 4q28.1; chr4:127623271-127716779 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a knock-out allele exhibit abnormal neural tube development, polydactyly, and die by E16.5.
 
Interactions
Intu interacts with 359 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process cell projection organization, cilium assembly, ...
Component cytoplasm
Function molecular_function
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (43)    Tissues (29)    Images (13)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 43
cDNA source data(5)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase intu    NEW 
Molecular
reagents
All nucleic(5) cDNA(5)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000060798 (Evidence)
Entrez Gene 380614 (Evidence)
DFCI TC1592262, TC1626467, TC1686568
DoTS DT.55152875, DT.91296983
NIA Mouse Gene Index U003184
International Mouse Phenotyping Consortium Status Intu
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 380614 NCBI Gene Model | MGI Sequence Detail 51073 C57BL/6J ±  kb
transcript NM_175515 RefSeq | MGI Sequence Detail 6387 C57BL/6 
polypeptide Q059U7 UniProt | EBI | MGI Sequence Detail 942 Not Applicable 

For the selected sequences
All sequences(24) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(294 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001478 PDZ domain
Protein Ontology PR:000030497 protein inturned
Graphical View of Protein Domain Structure
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:205544 Dai D, et al., Planar cell polarity effector gene Intu regulates cell fate-specific differentiation of keratinocytes through the primary cilia. Cell Death Differ. 2013 Jan;20(1):130-8
All references(25)
Other
accession IDs
MGI:1925153

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory