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Numa1 Gene Detail
Summary
  • Symbol
    Numa1
  • Name
    nuclear mitotic apparatus protein 1
  • Synonyms
    6720401E04Rik, NuMA
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443665
    NCBI Gene: 101706
Location & Maps
more
  • Sequence Map
    Chr7:101934111-102014964 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      80854 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 54.70 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    NUMA1, nuclear mitotic apparatus protein 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    NUMA1, nuclear mitotic apparatus protein 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    NMP-22, NUMA
  • Links
    NCBI Gene ID: 4926
    neXtProt AC: NX_Q14980
    UniProt: Q14980

  • Chr Location
    11q13.4; chr11:72002864-72080693 (-)  GRCh38.p7
Human Diseases
more
  • Diseases
    1 with human NUMA1 associations

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 3 alleles in 4 genetic backgrounds
    14 phenotypes from multigenic genotypes
    2 images
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out or hypomorphic allele exhibit embryonic lethality by E9.5.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    63
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    37
  • Tissues
    9
  • cDNA Data
    262
  • Literature Summary
    9
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035829 VEGA Gene Model | MGI Sequence Detail 80854 C57BL/6J ±  kb
transcript OTTMUST00000091764 VEGA | MGI Sequence Detail 7180 Not Applicable  
polypeptide OTTMUSP00000050572 VEGA | MGI Sequence Detail 2094 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    441 from dbSNP Build 142
Protein
Information
less
  • UniProt
    11 Sequences
  • InterPro Domains
    IPR026650 Nuclear mitotic apparatus protein 1
Molecular
Reagents
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  • All nucleic 262
    cDNA 262

    Microarray probesets 4
Other
Accession IDs
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MGI:2137869, MGI:2142083, MGI:2142110
References
more
  • Summaries
    All 55
    Developmental Gene Expression 9
    Diseases 1
    Gene Ontology 7
    Phenotypes 21
  • Earliest
    J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
  • Latest
    J:229900 Seldin L, et al., NuMA-microtubule interactions are critical for spindle orientation and the morphogenesis of diverse epidermal structures. Elife. 2016;5
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
07/11/2017
MGI 6.10 		The Jackson Laboratory