Numa1 MGI Mouse Gene Detail - MGI:2443665 - nuclear mitotic apparatus protein 1

Numa1 Gene Detail

Symbol

Numa1
Name

nuclear mitotic apparatus protein 1
Synonyms

6720401E04Rik, NuMA

Feature Type

protein coding gene
IDs

MGI:2443665
NCBI Gene: 101706
Alliance

gene page

Sequence Map

Chr7:101934111-102014964 bp, + strand
From VEGA annotation of GRCm38

Mouse Genome Browser
Download
Sequence

80854 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 54.70 cM
Mapping Data

2 experiments

Human Ortholog

NUMA1, nuclear mitotic apparatus protein 1

Vertebrate Orthologs

9

Human Ortholog

NUMA1, nuclear mitotic apparatus protein 1
Orthology source: HomoloGene, HGNC
Synonyms

NMP-22, NUMA
Links

HGNC:8059

NCBI Gene ID: 4926

neXtProt AC: NX_Q14980

UniProt: Q14980
Chr Location

11q13.4; chr11:72002864-72080693 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 38150
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: NUMA1
Gene Tree

Numa1

Diseases

1 with human NUMA1 associations

Human Disease

Mouse Models

acute promyelocytic leukemia

IDs

View 1 model

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

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Phenotype Summary

7 phenotypes from 3 alleles in 4 genetic backgrounds
14 phenotypes from multigenic genotypes
2 images
21 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

105
Chemically induced (other)

1
Gene trapped

99
Radiation induced

1
Targeted

3
Transgenic

1
Genomic Mutations

2 involving Numa1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

45 strains or lines available

Mice homozygous for a knock-out or hypomorphic allele exhibit embryonic lethality by E9.5.

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All GO Annotations

75
GO References

10

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

37
Tissues

9
cDNA Data

262
Literature Summary

10

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase numa1

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Numa1 interacts with 193 markers (Mir7-1, Mir7-2, Mir7b, ...) View All

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All Sequences

74
RefSeq

20
UniProt

10
CCDS

CCDS40046.1
UniGene

27259

			Length	Strain/Species	Flank
genomic	OTTMUSG00000035829	VEGA Gene Model \| MGI Sequence Detail	80854	C57BL/6J	± kb
transcript	OTTMUST00000091764	VEGA \| MGI Sequence Detail	7180	Not Applicable
polypeptide	OTTMUSP00000050572	VEGA \| MGI Sequence Detail	2094	Not Applicable

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SNPs within 2kb

441 from dbSNP Build 142

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UniProt

10 Sequences
Protein Ontology

PR:000011503 nuclear mitotic apparatus protein 1

(term hierarchy)
InterPro Domains

IPR026650 Nuclear mitotic apparatus protein 1

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All nucleic 262

cDNA 262

Microarray probesets 4

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MGI:2137869, MGI:2142083, MGI:2142110

Summaries

All 60

Developmental Gene Expression 10

Diseases 1

Gene Ontology 10

Phenotypes 21
Earliest

J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
Latest

J:249114 Cavalheiro GR, et al., N-myc regulates growth and fiber cell differentiation in lens development. Dev Biol. 2017 Sep 1;429(1):105-117

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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