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Numa1 Gene Detail
Summary
  • Symbol
    Numa1
  • Name
    nuclear mitotic apparatus protein 1
  • Synonyms
    6720401E04Rik, NuMA
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443665
    NCBI Gene: 101706
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:101934111-102014964 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 54.70 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    441 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443665
 protein coding gene Chr7:101934002-102014964 (+)
129S1/SvImJ MGP_129S1SvImJ_G0032595
 protein coding gene Chr7:104992699-105041123 (+)
A/J MGP_AJ_G0032571
 protein coding gene Chr7:102317632-102363064 (+)
AKR/J MGP_AKRJ_G0032507
 protein coding gene Chr7:104769677-104814765 (+)
BALB/cJ MGP_BALBcJ_G0032582
 protein coding gene Chr7:102010362-102057473 (+)
C3H/HeJ MGP_C3HHeJ_G0032296
 protein coding gene Chr7:105137246-105182969 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033079
 protein coding gene Chr7:108958429-109007227 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030073
 protein coding gene Chr7:104675353-104719558 (+)
CAST/EiJ MGP_CASTEiJ_G0031622
 protein coding gene Chr7:96700388-96748205 (+)
CBA/J MGP_CBAJ_G0032262
 protein coding gene Chr7:112723920-112769441 (+)
DBA/2J MGP_DBA2J_G0032414
 protein coding gene Chr7:100643152-100688647 (+)
FVB/NJ MGP_FVBNJ_G0032370
 protein coding gene Chr7:100430532-100475370 (+)
LP/J MGP_LPJ_G0032503
 protein coding gene Chr7:106311829-106356153 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032404
 protein coding gene Chr7:114047905-114094890 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033101
 protein coding gene Chr7:104036712-104081795 (+)
PWK/PhJ MGP_PWKPhJ_G0031340
 protein coding gene Chr7:93759388-93803742 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031184
 protein coding gene Chr7:91333217-91383529 (+)
WSB/EiJ MGP_WSBEiJ_G0031739
 protein coding gene Chr7:104728057-104771656 (+)



Homology
more
  • Human Ortholog
    NUMA1, nuclear mitotic apparatus protein 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    NUMA1, nuclear mitotic apparatus protein 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    NMP-22, NUMA
  • Links
    NCBI Gene ID: 4926
    neXtProt AC: NX_Q14980
    UniProt: Q14980

  • Chr Location
    11q13.4; chr11:72002864-72080693 (-)  GRCh38.p7
Human Diseases
more
  • Diseases
    1 with human NUMA1 associations

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 3 alleles in 4 genetic backgrounds
    14 phenotypes from multigenic genotypes
    2 images
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out or hypomorphic allele exhibit embryonic lethality by E9.5.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    80
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    39
  • Tissues
    10
  • cDNA Data
    263
  • Literature Summary
    10
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000066306 Ensembl Gene Model | MGI Sequence Detail 80854 C57BL/6J ±  kb
transcript ENSMUST00000084852 Ensembl | MGI Sequence Detail 7180 Not Applicable  
polypeptide ENSMUSP00000081912 Ensembl | MGI Sequence Detail 2094 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 263
    cDNA 263

    Microarray probesets 4
Other
Accession IDs
less
MGI:2137869, MGI:2142083, MGI:2142110
References
more
  • Summaries
    All 62
    Developmental Gene Expression 10
    Diseases 1
    Gene Ontology 11
    Phenotypes 21
  • Earliest
    J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
  • Latest
    J:275317 Magescas J, et al., Spindle pole cohesion requires glycosylation-mediated localization of NuMA. Sci Rep. 2017 May 3;7(1):1474
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
10/08/2019
MGI 6.14 		The Jackson Laboratory