Numa1 MGI Mouse Gene Detail - MGI:2443665 - nuclear mitotic apparatus protein 1

Symbol

Numa1
Name

nuclear mitotic apparatus protein 1
Synonyms

6720401E04Rik, NuMA

Feature Type

protein coding gene
IDs

MGI:2443665
NCBI Gene: 101706
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

Chr7:101583318-101664171 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 54.70 cM
Mapping Data

2 experiments

SNPs within 2kb

1642 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2443665	protein coding gene	Chr7:101583169-101664171 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0032595	protein coding gene	Chr7:104992699-105041123 (+)
A/J	MGP_AJ_G0032571	protein coding gene	Chr7:102317632-102363064 (+)
AKR/J	MGP_AKRJ_G0032507	protein coding gene	Chr7:104769677-104814765 (+)
BALB/cJ	MGP_BALBcJ_G0032582	protein coding gene	Chr7:102010362-102057473 (+)
C3H/HeJ	MGP_C3HHeJ_G0032296	protein coding gene	Chr7:105137246-105182969 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0033079	protein coding gene	Chr7:108958429-109007227 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030073	protein coding gene	Chr7:104675353-104719558 (+)
CAST/EiJ	MGP_CASTEiJ_G0031622	protein coding gene	Chr7:96700388-96748205 (+)
CBA/J	MGP_CBAJ_G0032262	protein coding gene	Chr7:112723920-112769441 (+)
DBA/2J	MGP_DBA2J_G0032414	protein coding gene	Chr7:100643152-100688647 (+)
FVB/NJ	MGP_FVBNJ_G0032370	protein coding gene	Chr7:100430532-100475370 (+)
LP/J	MGP_LPJ_G0032503	protein coding gene	Chr7:106311829-106356153 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0032404	protein coding gene	Chr7:114047905-114094890 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0033101	protein coding gene	Chr7:104036712-104081795 (+)
PWK/PhJ	MGP_PWKPhJ_G0031340	protein coding gene	Chr7:93759388-93803742 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0031184	protein coding gene	Chr7:91333217-91383529 (+)
WSB/EiJ	MGP_WSBEiJ_G0031739	protein coding gene	Chr7:104728057-104771656 (+)

Human Ortholog

NUMA1, nuclear mitotic apparatus protein 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NUMA1, nuclear mitotic apparatus protein 1
Synonyms

NMP-22, NUMA
Links

HGNC:8059

NCBI Gene ID: 4926

UniProt: Q14980
Chr Location

11q13.4; chr11:72002864-72080693 (-) GRCh38

MGI Vertebrate Homology

Numa1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: NUMA1
Gene Tree

Numa1

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Phenotype Summary

7 phenotypes from 3 alleles in 4 genetic backgrounds
2 images
23 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

91
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

83
Radiation induced

1
Targeted

3
Genomic Mutations

2 involving Numa1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

78 strains or lines available

Mice homozygous for a knock-out or hypomorphic allele exhibit embryonic lethality by E9.5.

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All GO Annotations

166
GO References

13

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

767
Tissues

28
cDNA Data

263
Literature Summary

20

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase numa1

ZFIN numa1

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All Sequences

91
RefSeq

34
UniProt

10
CCDS

CCDS40046.1

Ensembl

ENSMUSG00000066306 (Evidence)
NCBI Gene

101706

			Length	Strain/Species	Flank
genomic	ENSMUSG00000066306	Ensembl Gene Model \| MGI Sequence Detail	80854	C57BL/6J	± kb
transcript	ENSMUST00000084852	Ensembl \| MGI Sequence Detail	7180	Not Applicable
polypeptide	ENSMUSP00000081912	Ensembl \| MGI Sequence Detail	2094	Not Applicable

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UniProt

10 Sequences
Protein Ontology

PR:000011503 nuclear mitotic apparatus protein 1

(term hierarchy)
InterPro Domains

IPR051841 Microtubule and Golgi organization protein

IPR048726 Nuclear mitotic apparatus protein 1, LGN binding domain

IPR048724 Nuclear mitotic apparatus protein 1, N-terminal hook domain
GlyGen

E9Q7G0 5 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (3 sites)

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All nucleic 265

cDNA 263

Primer pair 2

Microarray probesets 4

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MGI:2137869, MGI:2142083, MGI:2142110

Summaries

All 78

Developmental Gene Expression 20

Gene Ontology 13

Phenotypes 23
Earliest

J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
Latest

J:338401 Nutter CA, et al., Choroid plexus mis-splicing and altered cerebrospinal fluid composition in myotonic dystrophy type 1. Brain. 2023 May 5;

TSS for Numa1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr68285	Chr7:101583160-101583233 (+)	-121 bp
Tssr68286	Chr7:101583283-101583397 (+)	22 bp
Tssr68287	Chr7:101618843-101618881 (+)	35,544 bp
Tssr68288	Chr7:101619003-101619047 (+)	35,707 bp
Tssr68289	Chr7:101619339-101619392 (+)	36,048 bp
Tssr68290	Chr7:101619398-101619413 (+)	36,088 bp
Tssr68291	Chr7:101619418-101619430 (+)	36,106 bp
Tssr68292	Chr7:101619849-101619896 (+)	36,555 bp
Tssr68293	Chr7:101619897-101619937 (+)	36,599 bp
Tssr68294	Chr7:101626080-101626087 (+)	42,766 bp
Tssr68295	Chr7:101642468-101642483 (+)	59,158 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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