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Siglecg
Gene Detail
Symbol

Name
ID
Siglecg
sialic acid binding Ig-like lectin G
MGI:2443630
Synonyms
A630096C01Rik, mSiglec-G
Feature Type
protein coding gene
Genetic Map
Chromosome 7
28.25 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:43408204-43418358 bp, + strand
From VEGA annotation of GRCm38

  10155 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:13228  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 24 western clawed frog

HCOP human homology predictions: SIGLEC10
Gene Tree: Siglecg

Human
homologs
SIGLEC10, sialic acid binding Ig-like lectin 10
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 89790
neXtProt AC: NX_Q96LC7

Human Synonyms: PRO940, SIGLEC-10, SLG2

Human Chr (Location): 19q13.3; chr19:51410021-51417803 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(3) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit increased B-1 cell numbers, increased IgM levels and IgM-producing plasma cells, and produce more IgM autoantibodies.
 
Interactions
Siglecg interacts with 82 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (2 annotations)
Process hematopoietic progenitor cell differentiation
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (6)    Tissues (1)    Images (6)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 6
cDNA source data(16)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(16) cDNA(16)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000031927 (Evidence)
Ensembl Gene Model ENSMUSG00000030468 (Evidence)
Entrez Gene 243958 (Evidence)
UniGene 24444
DFCI TC1699005, TC1587638, TC1662859
DoTS DT.94251347, DT.101723223, DT.94227925, DT.526808, DT.40175065
NIA Mouse Gene Index U008011
Consensus CDS Project CCDS52221.1
International Mouse Phenotyping Consortium Status Siglecg
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031927 VEGA Gene Model | MGI Sequence Detail 10155 C57BL/6J ±  kb
transcript OTTMUST00000079177 VEGA | MGI Sequence Detail 2569 Not Applicable 
polypeptide OTTMUSP00000042196 VEGA | MGI Sequence Detail 688 Not Applicable 

For the selected sequences
All sequences(50) RefSeq(10) UniProt(3)
Polymorphisms
SNPs within 2kb(137 from dbSNP Build 137)    SNPs within 2kb including multiple locations(141)
Protein-related
information
ResourceIDDescription
InterPro IPR013162 CD80-like, immunoglobulin C2-set
InterPro IPR013098 Immunoglobulin I-set
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
InterPro IPR003598 Immunoglobulin subtype 2
InterPro IPR013106 Immunoglobulin V-set
Protein Ontology PR:000014865 sialic acid-binding Ig-like lectin 11
References
(Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:212405 Toubai T, et al., Siglec-G-CD24 axis controls the severity of graft-versus-host disease in mice. Blood. 2014 May 29;123(22):3512-23
All references(37)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory