Sequence Detail

ID/Version

Q80ZE3 (UniProt | EBI)

Last sequence update: 2003-06-01
Last annotation update: 2024-01-24

Sequence description from provider

RecName: Full=Sialic acid-binding Ig-like lectin 10; Short=Siglec-10;AltName: Full=Sialic acid-binding Ig-like lectin G; Short=Siglec-G; Short=mSiglec-G;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 688 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Siglecg	sialic acid binding Ig-like lectin G	20	98	6	22

Sequence references in MGI

J:86117 Aizawa H, et al., Molecular analysis of human Siglec-8 orthologs relevant to mouse eosinophils: identification of mouse orthologs of Siglec-5 (mSiglec-F) and Siglec-10 (mSiglec-G). Genomics. 2003 Nov;82(5):521-30
J:123353 Hoffmann A, et al., Siglec-G is a B1 cell-inhibitory receptor that controls expansion and calcium signaling of the B1 cell population. Nat Immunol. 2007 Jul;8(7):695-704
J:156821 Duong BH, et al., Decoration of T-independent antigen with ligands for CD22 and Siglec-G can suppress immunity and induce B cell tolerance in vivo. J Exp Med. 2010 Jan 18;207(1):173-87, S1-4
J:160078 Jellusova J, et al., CD22 x Siglec-G double-deficient mice have massively increased B1 cell numbers and develop systemic autoimmunity. J Immunol. 2010 Apr 1;184(7):3618-27
J:193456 Chen W, et al., Induction of Siglec-G by RNA Viruses Inhibits the Innate Immune Response by Promoting RIG-I Degradation. Cell. 2013 Jan 31;152(3):467-78
J:205703 Pfrengle F, et al., Copresentation of antigen and ligands of Siglec-G induces B cell tolerance independent of CD22. J Immunol. 2013 Aug 15;191(4):1724-31
J:244884 Chen GY, et al., CD24 and Siglec-10 selectively repress tissue damage-induced immune responses. Science. 2009 Mar 27;323(5922):1722-5
J:265415 Hutzler S, et al., The ligand-binding domain of Siglec-G is crucial for its selective inhibitory function on B1 cells. J Immunol. 2014 Jun 1;192(11):5406-14
J:280035 Ding Y, et al., The lectin Siglec-G inhibits dendritic cell cross-presentation by impairing MHC class I-peptide complex formation. Nat Immunol. 2016 Oct;17(10):1167-75
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89