Slc9a6
Gene Detail

Symbol Name ID

Slc9a6 solute carrier family 9 (sodium/hydrogen exchanger), member 6 MGI:2443511

Synonyms

6430520C02Rik, mKIAA0267, NHE6

Feature Type

protein coding gene

Genetic Map

Chromosome X

30.06 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

ChrX:56609757-56664230 bp, + strand From VEGA annotation of GRCm38   54474 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:55971  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Slc9a6

Human homologs

Human Homolog		SLC9A6, solute carrier family 9, subfamily A (NHE6, cation proton antiporter 6), member 6
NCBI Gene ID		10479
neXtProt AC		NX_Q92581
Human Synonyms		MRSA, NHE6
Human Chr (Location)		XQ26.3; chrX:135067583-135129428 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human SLC9A6

Alleles and phenotypes

All alleles(5) : Targeted(5)
 

Male mice hemizygous for a targeted mutation display hyperactivity and susceptibility to pharmacologically induced seizures.

 

Gene Ontology (GO) classifications

All GO classifications: (12 annotations)

Process	ion transport, sodium ion transport, ...
Component	early endosome membrane, endoplasmic reticulum membrane, ...
Function	antiporter activity

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (255)    Tissues (115)    Images (108)
Theiler Stages: 23, 28

Assay Type	Results
RNA in situ	64
In situ reporter (knock in)	153
RT-PCR	38

cDNA source data(7)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(9) cDNA(7) Primer pair(2)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000017578 (Evidence)
Ensembl Gene Model	ENSMUSG00000060681 (Evidence)
Entrez Gene	236794 (Evidence)
DFCI	TC1580553, TC1597878
DoTS	DT.111023099, DT.40143501, DT.40161566
NIA Mouse Gene Index	U019864
Consensus CDS Project	CCDS40979.1
International Mouse Knockout Project Status	Slc9a6

Sequences

Length	Strain/Species
genomic	OTTMUSG00000017578	VEGA Gene Model | MGI Sequence Detail	54474	C57BL/6J
transcript	OTTMUST00000042740	VEGA | MGI Sequence Detail	4897	Not Applicable
polypeptide	OTTMUSP00000019196	VEGA | MGI Sequence Detail	702	Not Applicable

All sequences(38) RefSeq(2) UniProt(5)

Polymorphisms

SNPs(151 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR006153	Cation/H+ exchanger
InterPro	IPR018422	Cation/H+ exchanger, CPA1 family
InterPro	IPR004709	Na+/H+ exchanger
InterPro	IPR002090	Na+/H+ exchanger, isoform 6 (NHE6)
Protein Ontology	PR:000015218	sodium/hydrogen exchanger 6

References

(Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:193911 Deane EC, et al., Enhanced recruitment of endosomal Na+/H+ exchanger NHE6 into Dendritic spines of hippocampal pyramidal neurons during NMDA receptor-dependent long-term potentiation. J Neurosci. 2013 Jan 9;33(2):595-610
All references(32)