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Slc9a6
Gene Detail
Symbol

Name
ID
Slc9a6
solute carrier family 9 (sodium/hydrogen exchanger), member 6
MGI:2443511
Synonyms
6430520C02Rik, mKIAA0267, NHE6
Feature Type
protein coding gene
Genetic Map
Chromosome X
30.06 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
ChrX:56609757-56664230 bp, + strand
From VEGA annotation of GRCm38

  54474 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55971  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: SLC9A6
Gene Tree: Slc9a6

Human
homologs
SLC9A6, solute carrier family 9, subfamily A (NHE6, cation proton antiporter 6), member 6
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 10479
neXtProt AC: NX_Q92581

Human Synonyms: MRSA, NHE6

Human Chr (Location): XQ26.3; chrX:135985424-136047269 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human SLC9A6

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from APF )
 
Male mice hemizygous for a targeted mutation display hyperactivity and susceptibility to pharmacologically induced seizures.
 
Interactions
Slc9a6 interacts with 416 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (25 annotations)
Process axon extension, brain-derived neurotrophic factor receptor signaling pathway, ...
Component axonal spine, axon terminus, ...
Function molecular_function
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (255)    Tissues (115)    Images (108)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 64
In situ reporter (knock in) 153
RT-PCR 38
cDNA source data(7)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase slc9a6 ; ZFIN slc9a6b    NEW 
Molecular
reagents
All nucleic(9) cDNA(7) Primer pair(2)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000017578 (Evidence)
Ensembl Gene Model ENSMUSG00000060681 (Evidence)
Entrez Gene 236794 (Evidence)
DFCI TC1597878, TC1580553
DoTS DT.111023099, DT.40143501, DT.40161566
NIA Mouse Gene Index U019864
Consensus CDS Project CCDS40979.1
International Mouse Phenotyping Consortium Status Slc9a6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017578 VEGA Gene Model | MGI Sequence Detail 54474 C57BL/6J ±  kb
transcript OTTMUST00000042740 VEGA | MGI Sequence Detail 4897 Not Applicable 
polypeptide OTTMUSP00000019196 VEGA | MGI Sequence Detail 702 Not Applicable 

For the selected sequences
All sequences(42) RefSeq(6) UniProt(5)
Polymorphisms
SNPs within 2kb(169 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006153 Cation/H+ exchanger
InterPro IPR018422 Cation/H+ exchanger, CPA1 family
InterPro IPR004709 Na+/H+ exchanger
InterPro IPR002090 Na+/H+ exchanger, isoform 6 (NHE6)
Protein Ontology PR:000015218 sodium/hydrogen exchanger 6
References
(Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:201826 Ouyang Q, et al., Christianson Syndrome Protein NHE6 Modulates TrkB Endosomal Signaling Required for Neuronal Circuit Development. Neuron. 2013 Oct 2;80(1):97-112
All references(30)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory