Slc9a6 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Slc9a6
solute carrier family 9 (sodium/hydrogen exchanger), member 6
MGI:2443511

31 phenotypes from 2 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Slc9a6^tm1Dgen/Y B6.129P2-Slc9a6^tm1Dgen/J	abnormal amygdala morphology	J:229166, J:241124
	abnormal brain morphology	J:241124
	abnormal cerebellar molecular layer	J:229166
	abnormal cerebellum morphology	J:262453
	abnormal cerebral hemisphere morphology	J:262453
	abnormal enzyme/coenzyme activity	J:241124
	abnormal ganglioside level	J:229166, J:241124
	abnormal hippocampus morphology	J:262453
	abnormal neuron morphology	J:241124
	abnormal Purkinje cell axon morphology	J:241124
	abnormal spatial reference memory	J:229166
	astrocytosis	J:262453
	ataxia	J:229166
	normal behavior/neurological phenotype	J:241124
	decreased brain size	J:262453
	decreased striatum size	J:262453
	gliosis	J:229166
	impaired coordination	J:229166, J:241124
	increased locomotor activity	J:229166, J:241124
	increased vertical activity	J:241124
	microgliosis	J:262453
	Purkinje cell degeneration	J:229166, J:241124, J:262453
	small cerebellum	J:262453
	thin cerebral cortex	J:262453
Slc9a6^tm1Dgen/Slc9a6⁺ B6.129P2-Slc9a6^tm1Dgen/J	abnormal amygdala morphology	J:229166
	abnormal ganglioside level	J:229166
	abnormal hippocampus CA3 region morphology	J:229166
	abnormal hippocampus CA4 region morphology	J:229166
	abnormal spatial reference memory	J:229166
	decreased Purkinje cell number	J:262453
	gliosis	J:229166
	impaired coordination	J:229166
	Purkinje cell degeneration	J:229166
Slc9a6^tm1Dgen/Y involves: 129P2/OlaHsd * C57BL/6	increased locomotor activity	J:101679
Slc9a6^tm1Dgen/Y involves: 129P2/OlaHsd * C57BL/6	increased susceptibility to pharmacologically induced seizures	J:101679
Slc9a6^tm1Dgen/Slc9a6^tm1Dgen B6.129P2-Slc9a6^tm1Dgen/J	abnormal amygdala morphology	J:241124
	abnormal brain cholesterol level	J:241124
	abnormal brain morphology	J:241124
	abnormal cerebral cortex morphology	J:241124
	abnormal enzyme/coenzyme activity	J:241124
	abnormal ganglioside level	J:241124
	abnormal neuron morphology	J:241124
	abnormal Purkinje cell axon morphology	J:241124
	normal behavior/neurological phenotype	J:241124
	postnatal lethality, incomplete penetrance	J:241124
	Purkinje cell degeneration	J:241124
Slc9a6^tm1Tigm/Y B6J.Cg-Slc9a6^tm1Tigm	decreased Purkinje cell number	J:262453

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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