About   Help   FAQ
Sp8
Gene Detail
Symbol

Name
ID
Sp8
trans-acting transcription factor 8
MGI:2443471
Synonyms
D930049B17Rik, mBtd
Feature Type
protein coding gene
Genetic Map
Chromosome 12
63.48 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr12:118846329-118852578 bp, + strand
From Ensembl annotation of GRCm38

  6250 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:18548  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Sp8

Human
homologs
Human Homolog SP8, Sp8 transcription factor
NCBI Gene ID 221833
neXtProt AC  NX_Q8IXZ3
Human Synonyms  BTD
Human Chr (Location)  7p21.2; chr7:20782274-20786889 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutant fetuses are characterized by truncated limbs, the lack of a tail, and neural tube defects.
 
Interactions
Sp8 interacts with 350 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process dorsal/ventral pattern formation, embryonic limb morphogenesis, ...
Component nucleus
Function DNA binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (38 records)
Data Summary: Results (29)    Tissues (25)    Images (10)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 29
cDNA source data(11)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(12) Genomic(1) cDNA(11)
Microarray probesets(2)
Other database
links
Ensembl Gene ModelENSMUSG00000048562 (Evidence)
Entrez Gene320145 (Evidence)
UniGene51682
DFCITC1655441, TC1587219, TC1630342
DoTSDT.101353496, DT.91432758, DT.55182179
NIA Mouse Gene IndexU014496
Consensus CDS ProjectCCDS26213.1
International Mouse Knockout Project StatusSp8
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000048562 Ensembl Gene Model | MGI Sequence Detail 6250 C57BL/6J ±  kb
transcript ENSMUST00000063918 Ensembl | MGI Sequence Detail 4480 Not Applicable 
polypeptide ENSMUSP00000065746 Ensembl | MGI Sequence Detail 486 Not Applicable 

For the selected sequences
All sequences(37) RefSeq(16) UniProt(5)
Polymorphisms
SNPs within 2kb(11 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007087 Zinc finger, C2H2
InterPro IPR015880 Zinc finger, C2H2-like
InterPro IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology PR:000015446 transcription factor Sp8
References
(Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:214014 Vogt D, et al., Lhx6 directly regulates Arx and CXCR7 to determine cortical interneuron fate and laminar position. Neuron. 2014 Apr 16;82(2):350-64
All references(66)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
12/09/2014
MGI 5.20
The Jackson Laboratory