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Sp8 Gene Detail
Summary
  • Symbol
    Sp8
  • Name
    trans-acting transcription factor 8
  • Synonyms
    D930049B17Rik, mBtd
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443471
    NCBI Gene: 320145
  • Gene Overview
    MyGene.info: SP8
Location & Maps
more
  • Sequence Map
    Chr12:118846329-118852578 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      6250 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 63.48 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    SP8, Sp8 transcription factor
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SP8, Sp8 transcription factor
    Orthology source: HGNC, HomoloGene
  • Synonyms
    BTD
  • Links
    NCBI Gene ID: 221833
    neXtProt AC: NX_Q8IXZ3

  • Chr Location
    7p21.2; chr7:20781467-20786889 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 18548
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: SP8
  • Gene Tree
    Sp8
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    61 phenotypes from 5 alleles in 7 genetic backgrounds
    17 phenotypes from multigenic genotypes
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant fetuses are characterized by truncated limbs, the lack of a tail, and neural tube defects.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000048562 Ensembl Gene Model | MGI Sequence Detail 6250 C57BL/6J ±  kb
transcript ENSMUST00000063918 Ensembl | MGI Sequence Detail 4480 Not Applicable  
polypeptide ENSMUSP00000065746 Ensembl | MGI Sequence Detail 486 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    11 from dbSNP Build 142
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000015446 transcription factor Sp8
  • InterPro Domains
    IPR030450 Transcription factor Sp1 family
    IPR007087 Zinc finger, C2H2
    IPR015880 Zinc finger, C2H2-like
    IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Molecular
Reagents
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  • All nucleic 13
    Genomic 1
    cDNA 12

    Microarray probesets 2
References
more
  • Summaries
    All 73
    Developmental Gene Expression 49
    Gene Ontology 5
    Phenotypes 19
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:232050 Kennedy MW, et al., Sp5 and Sp8 recruit beta-catenin and Tcf1-Lef1 to select enhancers to activate Wnt target gene transcription. Proc Natl Acad Sci U S A. 2016 Mar 29;113(13):3545-50

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory