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Sp8
Gene Detail
Symbol

Name
ID
Sp8
trans-acting transcription factor 8
MGI:2443471
Synonyms
D930049B17Rik, mBtd
Feature Type
protein coding gene
Genetic Map
Chromosome 12
63.48 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr12:118846329-118852578 bp, + strand
From Ensembl annotation of GRCm38

  6250 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:18548  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: SP8
Gene Tree: Sp8

Human
homologs
SP8, Sp8 transcription factor
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 221833
neXtProt AC: NX_Q8IXZ3

Human Synonyms: BTD

Human Chr (Location): 7p21.2; chr7:20781467-20786889 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutant fetuses are characterized by truncated limbs, the lack of a tail, and neural tube defects.
 
Interactions
Sp8 interacts with 350 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process dorsal/ventral pattern formation, embryonic limb morphogenesis, ...
Component nucleus
Function DNA binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (42 records)
Data Summary: Results (57)    Tissues (47)    Images (16)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 57
cDNA source data(12)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase sp8 ; ZFIN sp8a, sp8b    NEW 
Molecular
reagents
All nucleic(13) Genomic(1) cDNA(12)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000048562 (Evidence)
Entrez Gene 320145 (Evidence)
UniGene 51682
DFCI TC1587219, TC1630342, TC1655441
DoTS DT.101353496, DT.55182179, DT.91432758
NIA Mouse Gene Index U014496
Consensus CDS Project CCDS26213.1
International Mouse Phenotyping Consortium Status Sp8
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000048562 Ensembl Gene Model | MGI Sequence Detail 6250 C57BL/6J ±  kb
transcript ENSMUST00000063918 Ensembl | MGI Sequence Detail 4480 Not Applicable 
polypeptide ENSMUSP00000065746 Ensembl | MGI Sequence Detail 486 Not Applicable 

For the selected sequences
All sequences(37) RefSeq(18) UniProt(3)
Polymorphisms
SNPs within 2kb(11 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007087 Zinc finger, C2H2
InterPro IPR015880 Zinc finger, C2H2-like
InterPro IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology PR:000015446 transcription factor Sp8
References
(Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:222465 Borello U, et al., Sp8 and COUP-TF1 reciprocally regulate patterning and Fgf signaling in cortical progenitors. Cereb Cortex. 2014 Jun;24(6):1409-21
All references(68)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory