Symbol
Name
ID

Sp8
trans-acting transcription factor 8
MGI:2443471

Phenotype annotations related to craniofacial

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Mouse Phenotypes

craniofacial phenotype

abnormal craniofacial morphology

abnormal frontal bone morphology

absent frontal bone

abnormal interparietal bone morphology

absent interparietal bone

abnormal supraoccipital bone morphology

small supraoccipital bone

abnormal parietal bone morphology

absent parietal bone

abnormal maxilla morphology

abnormal premaxilla morphology

small premaxilla

small maxilla

abnormal craniofacial development

abnormal lateral nasal prominence morphology

abnormal maxillary prominence morphology

abnormal medial nasal prominence morphology

abnormal palatal shelf elevation

palatal shelves fail to meet at midline

decreased palatal shelf size

abnormal face development

cleft upper lip

abnormal palate morphology

cleft palate

abnormal nose morphology

small snout

midline facial cleft

Availability

Mouse Genotype

Sp8^tm1Aman/Sp8^tm1Aman

Sp8^tm1Smb/Sp8^tm1Smb

Sp8^tm1Smb/Sp8^tm1Smb
Shh^{tm1(EGFP/cre)Cjt}/Shh⁺ (conditional)

Sp8^tm2.1Aman/Sp8^tm2.1Aman
Foxg1^tm1(cre)Skm/Foxg1⁺ (conditional)

Sp8^tm1Smb/Sp8^tm2Smb
Foxg1^tm1(cre)Skm/Foxg1⁺ (conditional)

Sp8^tm1Smb/Sp8^tm2Smb
H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺ (conditional)

Sp8^tm1Smb/Sp8^tm2Smb
Mesp1^tm2(cre)Ysa/Mesp1⁺ (conditional)

Sp8^tm1Smb/Sp8^tm2Smb
Pax3^tm1(cre)Joe/Pax3⁺ (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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