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Dgki Gene Detail
Summary
  • Symbol
    Dgki
  • Name
    diacylglycerol kinase, iota
  • Synonyms
    C130010K08Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443430
    NCBI Gene: 320127
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:36846022-37300184 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 15.60 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    2680 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443430
protein coding gene Chr6:36837381-37300184 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030575
protein coding gene Chr6:35027037-35503146 (-)
A/J MGP_AJ_G0030548
protein coding gene Chr6:33529387-33991074 (-)
AKR/J MGP_AKRJ_G0030475
protein coding gene Chr6:34602837-35079581 (-)
BALB/cJ MGP_BALBcJ_G0030558
protein coding gene Chr6:33718771-34177908 (-)
C3H/HeJ MGP_C3HHeJ_G0030271
protein coding gene Chr6:34616096-35085906 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031012
protein coding gene Chr6:35911136-36405598 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028224
protein coding gene Chr6:31462717-31904103 (-)
CAST/EiJ MGP_CASTEiJ_G0029673
protein coding gene Chr6:34434837-34917350 (-)
CBA/J MGP_CBAJ_G0030249
protein coding gene Chr6:37295611-37797366 (-)
DBA/2J MGP_DBA2J_G0030393
protein coding gene Chr6:33367524-33824177 (-)
FVB/NJ MGP_FVBNJ_G0030347
protein coding gene Chr6:33156136-33613976 (-)
LP/J MGP_LPJ_G0030480
protein coding gene Chr6:35137917-35597930 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030383
protein coding gene Chr6:39711234-40198521 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031042
protein coding gene Chr6:34511193-34985048 (-)
PWK/PhJ MGP_PWKPhJ_G0029387
protein coding gene Chr6:32969601-33456027 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029223
protein coding gene Chr6:34174794-34674904 (-)
WSB/EiJ MGP_WSBEiJ_G0029749
protein coding gene Chr6:34453365-34934343 (-)



Homology
more
  • Human Ortholog
    DGKI, diacylglycerol kinase iota
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DGKI, diacylglycerol kinase iota
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DGK-IOTA
  • Links
    NCBI Gene ID: 9162
    neXtProt AC: NX_O75912
    UniProt: O75912

  • Chr Location
    7q33; chr7:137384283-137846864 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 37956
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: DGKI
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    8 phenotype references
Mice homozygous for a knock-out allele are grossly normal and do not develop tumors when wounded or when exposed to phorbol ester.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000038665 Ensembl Gene Model | MGI Sequence Detail 454163 C57BL/6J ±  kb
transcript ENSMUST00000101532 Ensembl | MGI Sequence Detail 4596 Not Applicable  
polypeptide ENSMUSP00000099071 Ensembl | MGI Sequence Detail 1071 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    5 Sequences
  • EC
  • InterPro Domains
    IPR002110 Ankyrin repeat
    IPR020683 Ankyrin repeat-containing domain
    IPR036770 Ankyrin repeat-containing domain superfamily
    IPR037607 Diacylglycerol kinase
    IPR000756 Diacylglycerol kinase, accessory domain
    IPR001206 Diacylglycerol kinase, catalytic domain
    IPR017438 Inorganic polyphosphate/ATP-NAD kinase, N-terminal
    IPR016064 NAD kinase/diacylglycerol kinase-like domain superfamily
    IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
Molecular
Reagents
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  • All nucleic 8
    cDNA 6
    Primer pair 2

    Microarray probesets 2
References
more
  • Summaries
    All 27
    Developmental Gene Expression 3
    Gene Ontology 5
    Phenotypes 8
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:277275 Bartsch VB, et al., Enhanced histamine-induced itch in diacylglycerol kinase iota knockout mice. PLoS One. 2019;14(6):e0217819

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory