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Kdm7a Gene Detail
Summary
  • Symbol
    Kdm7a
  • Name
    lysine (K)-specific demethylase 7A
  • Synonyms
    A630082K20Rik, ENSMUSG00000073143, Jhdm1d, Kdm7a, mKIAA1718
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443388
    NCBI Gene: 338523
Location & Maps
more
  • Sequence Map
    Chr6:39136623-39206789 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      70167 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 17.87 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    KDM7A, lysine demethylase 7A
  • Vertebrate Orthologs
    10
  • Human Ortholog
    KDM7A, lysine demethylase 7A
    Orthology source: HomoloGene, HGNC
  • Synonyms
    JHDM1D
  • Links
    NCBI Gene ID: 80853
    neXtProt AC: NX_Q6ZMT4

  • Chr Location
    7q34; chr7:140084746-140176956 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 25281
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: KDM7A
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutants exhibit abnormal hair follicle, tail, sebaceous gland, rib, and vertebrae morphology and decreased circulating iron levels.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022808 VEGA Gene Model | MGI Sequence Detail 70167 C57BL/6J ±  kb
transcript OTTMUST00000054819 VEGA | MGI Sequence Detail 9566 Not Applicable  
polypeptide OTTMUSP00000026192 VEGA | MGI Sequence Detail 940 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    163 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 16
    cDNA 16

    Microarray probesets 5
Other
Accession IDs
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MGI:2141725, MGI:3642369
References
more
  • Summaries
    All 33
    Gene Ontology 3
    Phenotypes 9
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:209956 Liakath-Ali K, et al., Novel skin phenotypes revealed by a genome-wide mouse reverse genetic screen. Nat Commun. 2014;5:3540

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory