Plekhm1
Gene Detail

Symbol Name ID

Plekhm1 pleckstrin homology domain containing, family M (with RUN domain) member 1 MGI:2443207

Synonyms

AP162, B2, D330036J23Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 11

67.09 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr11:103365088-103412664 bp, - strand From VEGA annotation of GRCm38   47577 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:8871  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken; 1 zebrafish

Gene Tree: Plekhm1

Human homologs

Human Homolog		PLEKHM1, pleckstrin homology domain containing, family M (with RUN domain) member 1
NCBI Gene ID		9842
neXtProt AC		NX_Q9Y4G2
Human Synonyms		AP162, B2, OPTB6
Human Chr (Location)		17q21.31; chr17:43513266-43568146 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human PLEKHM1

Alleles and phenotypes

All alleles(234) : Targeted(3) Gene trapped(231)
 

Mice homozygous for a gene trap insertion do not exhibit a detectable mutant phenotype.

 

Gene Ontology (GO) classifications

All GO classifications: (5 annotations)

Process	intracellular signal transduction
Component	cytoplasm
Function	metal ion binding, phospholipid binding, ...

External Resources: FuncBase

Expression

cDNA source data(9)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(9) cDNA(9)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000002841 (Evidence)
Ensembl Gene Model	ENSMUSG00000034247 (Evidence)
Entrez Gene	353047 (Evidence)
DFCI	TC1574689, TC1637403, TC1646257, TC1704917
DoTS	DT.110540079, DT.110540082, DT.110540123, DT.530755, DT.91410552
NIA Mouse Gene Index	U033507, U093714
Consensus CDS Project	CCDS25518.1
International Mouse Knockout Project Status	Plekhm1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000002841	VEGA Gene Model | MGI Sequence Detail	47577	C57BL/6J
transcript	OTTMUST00000005762	VEGA | MGI Sequence Detail	5132	Not Applicable
polypeptide	OTTMUSP00000002735	VEGA | MGI Sequence Detail	1074	Not Applicable

All sequences(49) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(230 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR025258	Domain of unknown function DUF4206
InterPro	IPR001849	Pleckstrin homology domain
InterPro	IPR011993	Pleckstrin homology-like domain
InterPro	IPR002219	Protein kinase C-like, phorbol ester/diacylglycerol binding
InterPro	IPR004012	RUN
Protein Ontology	PR:000012864	pleckstriny domain-containing family M member 1

References

(Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:180994 Ye S, et al., LIS1 regulates osteoclast formation and function through its interactions with dynein/dynactin and Plekhm1. PLoS One. 2011;6(11):e27285
All references(37)