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Plekhm1
Gene Detail
 Symbol
Name
ID
Plekhm1
pleckstrin homology domain containing, family M (with RUN domain) member 1
MGI:2443207
Synonyms AP162, B2, D330036J23Rik
Feature Type protein coding gene
Genetic Map
Chromosome 11
67.09 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:103364275-103412687 bp, - strand
From VEGA annotation of GRCm38

  48413 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8871  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Plekhm1

Human
homologs
Human Homolog PLEKHM1, pleckstrin homology domain containing, family M (with RUN domain) member 1
NCBI Gene ID 9842
neXtProt AC  NX_Q9Y4G2
Human Synonyms  AP162, B2, OPTB6
Human Chr (Location)  17q21.31; chr17:45435900-45490780 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human PLEKHM1
Mutations,
alleles, and
phenotypes
All mutations/alleles(236) : Gene trapped(231) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a gene trap insertion do not exhibit a detectable mutant phenotype.
 
Interactions
Plekhm1 interacts with 278 markers (Mir7b, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (4 annotations)
Process intracellular signal transduction
Component cytoplasm
Function metal ion binding, protein binding
External Resources: FuncBase
Expression
cDNA source data(9)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(9) cDNA(9)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000002841 (Evidence)
Ensembl Gene ModelENSMUSG00000034247 (Evidence)
Entrez Gene353047 (Evidence)
DFCITC1574689, TC1637403, TC1646257, TC1704917
DoTSDT.110540079, DT.110540082, DT.110540123, DT.530755, DT.91410552
NIA Mouse Gene IndexU033507, U093714
Consensus CDS ProjectCCDS25518.1
International Mouse Knockout Project StatusPlekhm1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000002841 VEGA Gene Model | MGI Sequence Detail 48413 C57BL/6J ±  kb
transcript OTTMUST00000005762 VEGA | MGI Sequence Detail 5968 Not Applicable 
polypeptide OTTMUSP00000002735 VEGA | MGI Sequence Detail 1074 Not Applicable 

For the selected sequences
All sequences(54) RefSeq(2) UniProt(2)
Polymorphisms SNPs within 2kb(304 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR025258 Domain of unknown function DUF4206
InterPro IPR001849 Pleckstrin homology domain
InterPro IPR011993 Pleckstrin homology-like domain
InterPro IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol binding
InterPro IPR004012 RUN
Protein Ontology PR:000012864 pleckstrin homology domain-containing family M member 1
References (Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:180994 Ye S, et al., LIS1 regulates osteoclast formation and function through its interactions with dynein/dynactin and Plekhm1. PLoS One. 2011;6(11):e27285
All references(38)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory