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Targeted Allele Detail
Symbol: Plekhm1tm1.2Hzhao
Name: pleckstrin homology domain containing, family M (with RUN domain) member 1; targeted mutation 1.2, Haibo Zhao
MGI ID: MGI:5888869
Synonyms: Plekhm1-
Gene: Plekhm1  Location: Chr11:103255101-103303513 bp, - strand  Genetic Position: Chr11, 67.09 cM
Alliance: Plekhm1tm1.2Hzhao page
Germline Transmission:  Earliest citation of germline transmission: J:236517
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  (129S6/SvEvTac x C57BL/6J)F1
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsThe targeting vector was designed to insert a loxP site upstream of exon 3 and an FRT-flanked neomycin resistance (neo) cassette, followed by a second loxP site, downstream of exon 3. Germline Flp- and Cre- mediated recombination removed the FRT-flanked neo cassette and exon 3 sequences. Quantitative real-time PCR analysis confirmed the absence of exon 3 genomic DNA in several soft tissues and tibial bone from homozygous mutant mice. (J:236517)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Plekhm1 Mutation:  187 strains or lines available
Original:  J:236517 Fujiwara T, et al., PLEKHM1/DEF8/RAB7 complex regulates lysosome positioning and bone homeostasis. JCI Insight. 2016 Oct 20;1(17):e86330
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory