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Gen1 Gene Detail
Summary
  • Symbol
    Gen1
  • Name
    GEN1, Holliday junction 5' flap endonuclease
  • Synonyms
    5830483C08Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443149
    NCBI Gene: 209334
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:11239718-11266029 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 5.58 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    161 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443149
protein coding gene Chr12:11238920-11266029 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019598
protein coding gene Chr12:8430619-8457261 (-)
A/J MGP_AJ_G0019565
protein coding gene Chr12:8124892-8149572 (-)
AKR/J MGP_AKRJ_G0019535
protein coding gene Chr12:8655680-8684285 (-)
BALB/cJ MGP_BALBcJ_G0019540
protein coding gene Chr12:8313119-8338166 (-)
C3H/HeJ MGP_C3HHeJ_G0019346
protein coding gene Chr12:8458454-8483022 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019989
protein coding gene Chr12:8724314-8750068 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017616
protein coding gene Chr12:7881974-7908991 (-)
CAST/EiJ MGP_CASTEiJ_G0018902
protein coding gene Chr12:8416874-8443030 (-)
CBA/J MGP_CBAJ_G0019317
protein coding gene Chr12:9336778-9363260 (-)
DBA/2J MGP_DBA2J_G0019430
protein coding gene Chr12:8092251-8117670 (-)
FVB/NJ MGP_FVBNJ_G0019421
protein coding gene Chr12:8038815-8064808 (-)
LP/J MGP_LPJ_G0019501
protein coding gene Chr12:8487913-8513806 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019454
protein coding gene Chr12:9162101-9187882 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020028
protein coding gene Chr12:8332666-8359956 (-)
PWK/PhJ MGP_PWKPhJ_G0018668
protein coding gene Chr12:8189219-8214122 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018458
protein coding gene Chr12:8412101-8440724 (-)
WSB/EiJ MGP_WSBEiJ_G0018953
protein coding gene Chr12:8405713-8432174 (-)



Homology
more
  • Human Ortholog
    GEN1, GEN1, Holliday junction 5' flap endonuclease
  • Vertebrate Orthologs
    8
  • Human Ortholog
    GEN1, GEN1, Holliday junction 5' flap endonuclease
    Orthology source: HomoloGene, HGNC
  • Synonyms
    Gen
  • Links
    NCBI Gene ID: 348654
    neXtProt AC: NX_Q17RS7
    UniProt: Q17RS7

  • Chr Location
    2p24.2; chr2:17753687-17785920 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 209334 NCBI Gene Model | MGI Sequence Detail 26312 C57BL/6J ±  kb
transcript NM_177331 RefSeq | MGI Sequence Detail 3302 C57BL/6  
polypeptide Q8BMI4 UniProt | EBI | MGI Sequence Detail 908 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 12
    Genomic 2
    cDNA 10

    Microarray probesets 3
References
more
  • Summaries
    All 29
    Gene Ontology 5
    Phenotypes 8
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:265628 Gaudet P, et al., Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief Bioinform. 2011 Sep;12(5):449-62

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory