Gen1 Phenotype Annotations - Multigenic Genotypes

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Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Gen1
GEN1, Holliday junction 5' flap endonuclease
MGI:2443149

5 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Eme1^{Tn(pb-Act-RFP)1.1Zhu}/Eme1⁺ Gen1^{Tn(pb-Act-RFP)1.1Zhu}/Gen1^{Tn(pb-Act-RFP)1.1Zhu} FVB/NJ-Eme1^{Tn(pb-Act-RFP)1.1Zhu} Gen1^{Tn(pb-Act-RFP)1.1Zhu}	increased cellular sensitivity to DNA damaging agents	J:330453
Eme1^{Tn(pb-Act-RFP)1.1Zhu}/Eme1⁺ Gen1^{Tn(pb-Act-RFP)1.1Zhu}/Gen1^{Tn(pb-Act-RFP)1.1Zhu} involves: C57BL/6J * FVB/NJ	abnormal cell physiology	J:330453
	normal reproductive system phenotype	J:330453
Eme1^{Tn(pb-Act-RFP)1.1Zhu}/Eme1^{Tn(pb-Act-RFP)1.1Zhu} Gen1^{Tn(pb-Act-RFP)1.1Zhu}/Gen1⁺ FVB/NJ-Eme1^{Tn(pb-Act-RFP)1.1Zhu} Gen1^{Tn(pb-Act-RFP)1.1Zhu}	prenatal lethality, complete penetrance	J:330453
Eme1^{Tn(pb-Act-RFP)1.1Zhu}/Eme1^{Tn(pb-Act-RFP)1.1Zhu} Gen1^{Tn(pb-Act-RFP)1.1Zhu}/Gen1^{Tn(pb-Act-RFP)1.1Zhu} FVB/NJ-Eme1^{Tn(pb-Act-RFP)1.1Zhu} Gen1^{Tn(pb-Act-RFP)1.1Zhu}	embryonic lethality before implantation, complete penetrance	J:330453

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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