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Trpm3 Gene Detail
Summary
  • Symbol
    Trpm3
  • Name
    transient receptor potential cation channel, subfamily M, member 3
  • Synonyms
    6330504P12Rik, B930001P07Rik, LTRPC3, melastatin 2, MLSN2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443101
    NCBI Gene: 226025
  • Gene Overview
    MyGene.info: TRPM3
  • Alliance
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:22139119-22989884 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 16.05 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    13654 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443101
protein coding gene Chr19:22137798-22989897 (.)
129S1/SvImJ MGP_129S1SvImJ_G0024982
protein coding gene Chr19:20209495-21090649 (+)
A/J MGP_AJ_G0024959
protein coding gene Chr19:19103731-19950910 (+)
AKR/J MGP_AKRJ_G0024929
protein coding gene Chr19:19832481-20704680 (+)
BALB/cJ MGP_BALBcJ_G0024958
protein coding gene Chr19:19142066-19987887 (+)
C3H/HeJ MGP_C3HHeJ_G0024716
protein coding gene Chr19:19792549-20666787 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025400
protein coding gene Chr19:20887095-21789148 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022819
protein coding gene Chr19:19300245-20137321 (+)
CAST/EiJ MGP_CASTEiJ_G0024184
protein coding gene Chr19:19475621-20368832 (+)
CBA/J MGP_CBAJ_G0024694
protein coding gene Chr19:21724844-22689093 (+)
DBA/2J MGP_DBA2J_G0024826
protein coding gene Chr19:19107153-19962184 (+)
FVB/NJ MGP_FVBNJ_G0024787
protein coding gene Chr19:18986078-19819937 (+)
LP/J MGP_LPJ_G0024910
protein coding gene Chr19:20158706-21033657 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024814
protein coding gene Chr19:21866136-22796291 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025455
protein coding gene Chr19:19765069-20676300 (+)
PWK/PhJ MGP_PWKPhJ_G0023933
protein coding gene Chr19:18672850-19526914 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023738
protein coding gene Chr19:19053568-19920078 (+)
WSB/EiJ MGP_WSBEiJ_G0024252
protein coding gene Chr19:19849181-20719141 (+)



Homology
more
  • Human Ortholog
    TRPM3, transient receptor potential cation channel subfamily M member 3
  • Vertebrate Orthologs
    9
  • Human Ortholog
    TRPM3, transient receptor potential cation channel subfamily M member 3
    Orthology source: HGNC, HomoloGene
  • Synonyms
    GON-2, LTRPC3, MLSN2
  • Links
    NCBI Gene ID: 80036
    neXtProt AC: NX_Q9HCF6
    UniProt: Q9HCF6

  • Chr Location
    9q21.12-q21.13; chr9:70529063-71446989 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation display impaired thermal and chemical nociception.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000052387 Ensembl Gene Model | MGI Sequence Detail 850766 C57BL/6J ±  kb
transcript ENSMUST00000099569 Ensembl | MGI Sequence Detail 6740 Not Applicable  
polypeptide ENSMUSP00000097164 Ensembl | MGI Sequence Detail 1721 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    37 Sequences
  • InterPro Domains
    IPR005821 Ion transport domain
    IPR029588 Transient receptor potential cation channel subfamily M member 1
    IPR029583 Transient receptor potential cation channel subfamily M member 3
    IPR032415 TRPM, tetramerisation domain
    IPR037162 TRPM, tetramerisation domain superfamily
Molecular
Reagents
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  • All nucleic 34
    cDNA 30
    Primer pair 4

    Microarray probesets 6
Other
Accession IDs
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MGI:2147643, MGI:2662432
References
more
  • Summaries
    All 49
    Developmental Gene Expression 13
    Gene Ontology 1
    Phenotypes 12
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:261812 Vandewauw I, et al., A TRP channel trio mediates acute noxious heat sensing. Nature. 2018 Mar 29;555(7698):662-666

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/04/2018
MGI 6.13
The Jackson Laboratory