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Ttll1
Gene Detail
 Symbol
Name
ID
Ttll1
tubulin tyrosine ligase-like 1
MGI:2443047
Synonyms 6330444E16Rik
Feature Type protein coding gene
Genetic Map
Chromosome 15
39.40 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr15:83483772-83510893 bp, - strand
From VEGA annotation of GRCm38

  27122 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8174  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Ttll1

Human
homologs
Human Homolog TTLL1, tubulin tyrosine ligase-like family, member 1
NCBI Gene ID 25809
neXtProt AC  NX_O95922
Human Synonyms  C22orf7, HS323M22B
Human Chr (Location)  22q13.1; chr22:43039516-43089428 (-)  GRCh38
Alleles
and
phenotypes
All alleles(7) : Gene trapped(4) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit short sperm flagellum, abnormal tracheal cilia morphology and function, abnormal mucociliary clearance, and rhinosinitus with coughing or sneezing-like noises.
 
Human Diseases Modeled Using Mouse Ttll1 (1)    Alleles Annotated to Human Diseases(1)   
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process axoneme assembly, cellular protein modification process, ...
Component cytoplasm, cytoskeleton, ...
Function ligase activity, protein binding
External Resources: FuncBase
Expression
cDNA source data(37)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(40) Genomic(2) cDNA(37) Primer pair(1)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000023450 (Evidence)
Ensembl Gene ModelENSMUSG00000022442 (Evidence)
Entrez Gene319953 (Evidence)
UniGene235007
DFCITC1575129, TC1593438, TC1762591, TC1763882
DoTSDT.485350, DT.91329215, DT.94274442, DT.94274443
NIA Mouse Gene IndexU036477
EC6.-.-.-
Consensus CDS ProjectCCDS27702.1
International Mouse Knockout Project StatusTtll1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023450 VEGA Gene Model | MGI Sequence Detail 27122 C57BL/6J ±  kb
transcript OTTMUST00000057014 VEGA | MGI Sequence Detail 2057 Not Applicable 
polypeptide OTTMUSP00000027458 VEGA | MGI Sequence Detail 423 Not Applicable 

For the selected sequences
All sequences(62) RefSeq(6) UniProt(3)
Polymorphisms SNPs within 2kb(142 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004344 Tubulin-tyrosine ligase
Protein Ontology PR:000032221 probable tubulin polyglutamylase TTLL1
References (Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(37)
Other
accession IDs
MGI:2146161

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory