Ttll1
Gene Detail

Symbol Name ID

Ttll1 tubulin tyrosine ligase-like 1 MGI:2443047

Synonyms

6330444E16Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 15

39.40 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr15:83483772-83510893 bp, - strand From VEGA annotation of GRCm38   27122 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:8174  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Ttll1

Human homologs

Human Homolog		TTLL1, tubulin tyrosine ligase-like family, member 1
NCBI Gene ID		25809
neXtProt AC		NX_O95922
Human Synonyms		C22orf7, HS323M22B
Human Chr (Location)		22q13.1; chr22:43435522-43485434 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(7) : Targeted(3) Gene trapped(4)
 

Mice homozygous for a knock-out allele exhibit short sperm flagellum, abnormal tracheal cilia morphology and function, abnormal mucociliary clearance, and rhinosinitus with coughing or sneezing-like noises.

 
Human Diseases Modeled Using Mouse Ttll1 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (14 annotations)

Process	cellular protein modification process, cilium axoneme assembly, ...
Component	cytoplasm, cytoskeleton, ...
Function	ATP binding, ligase activity, ...

External Resources: FuncBase

Expression

cDNA source data(37)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(40) Genomic(2) cDNA(37) Primer pair(1)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000023450 (Evidence)
Ensembl Gene Model	ENSMUSG00000022442 (Evidence)
Entrez Gene	319953 (Evidence)
UniGene	235007
DFCI	TC1575129, TC1593438, TC1762591, TC1763882
DoTS	DT.485350, DT.91329215, DT.94274442, DT.94274443
NIA Mouse Gene Index	U036477
EC	6.-.-.-
Consensus CDS Project	CCDS27702.1
International Mouse Knockout Project Status	Ttll1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000023450	VEGA Gene Model | MGI Sequence Detail	27122	C57BL/6J
transcript	OTTMUST00000057014	VEGA | MGI Sequence Detail	2057	Not Applicable
polypeptide	OTTMUSP00000027458	VEGA | MGI Sequence Detail	423	Not Applicable

All sequences(59) RefSeq(2) UniProt(4)

Polymorphisms

SNPs(95 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR013816	ATP-grasp fold, subdomain 2
InterPro	IPR004344	Tubulin-tyrosine ligase
Protein Ontology	PR:000032221	probable tubulin polyglutamylase TTLL1

References

(Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(37)

Other accession IDs

MGI:2146161