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Ttll1 Gene Detail
Summary
  • Symbol
    Ttll1
  • Name
    tubulin tyrosine ligase-like 1
  • Synonyms
    6330444E16Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443047
    NCBI Gene: 319953
  • Gene Overview
    MyGene.info: TTLL1
Location & Maps
more
  • Sequence Map
    Chr15:83483772-83510893 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      27122 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 39.40 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    TTLL1, tubulin tyrosine ligase like 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    TTLL1, tubulin tyrosine ligase like 1
    Orthology source: HomoloGene
  • Synonyms
    C22orf7, HS323M22B
  • Links
    NCBI Gene ID: 25809
    neXtProt AC: NX_O95922

  • Chr Location
    22q13.1; chr22:43039516-43089428 (-)  GRCh38.p2

Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    29 phenotypes from 3 alleles in 3 genetic backgrounds
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    10
  • Chemically induced (other)
    1
  • Gene trapped
    4
  • Radiation induced
    2
  • Targeted
    3
  • Genomic Mutations
    3 involving Ttll1
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit short sperm flagellum, abnormal tracheal cilia morphology and function, abnormal mucociliary clearance, and rhinosinitus with coughing or sneezing-like noises.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023450 VEGA Gene Model | MGI Sequence Detail 27122 C57BL/6J ±  kb
transcript OTTMUST00000057014 VEGA | MGI Sequence Detail 2057 Not Applicable  
polypeptide OTTMUSP00000027458 VEGA | MGI Sequence Detail 423 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    143 from dbSNP Build 142
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000032221 tubulin polyglutamylase TTLL1
  • EC
  • InterPro Domains
    IPR027750 Tubulin polyglutamylase TTLL1
    IPR004344 Tubulin-tyrosine ligase/Tubulin polyglutamylase
Molecular
Reagents
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  • All nucleic 40
    Genomic 2
    cDNA 37
    Primer pair 1

    Microarray probesets 6
Other
Accession IDs
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MGI:2146161
References
more
  • Summaries
    All 32
    Diseases 1
    Gene Ontology 5
    Phenotypes 25
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory