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Ttll1
Gene Detail
Symbol

Name
ID
Ttll1
tubulin tyrosine ligase-like 1
MGI:2443047
Synonyms
6330444E16Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 15
39.40 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr15:83483772-83510893 bp, - strand
From VEGA annotation of GRCm38

  27122 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8174  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: TTLL1
Gene Tree: Ttll1

Human
homologs
TTLL1, tubulin tyrosine ligase-like family member 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 25809
neXtProt AC: NX_O95922

Human Synonyms: C22orf7, HS323M22B

Human Chr (Location): 22q13.1; chr22:43039516-43089428 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(4) Radiation induced(1) Targeted(3)
Genomic Mutations involving Ttll1 (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a knock-out allele exhibit short sperm flagellum, abnormal tracheal cilia morphology and function, abnormal mucociliary clearance, and rhinosinitus with coughing or sneezing-like noises.
 
Phenotype Images(2)
Interactions
Ttll1 interacts with 129 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process axoneme assembly, cellular protein modification process, ...
Component cytoplasm, cytoskeleton, ...
Function ligase activity, protein binding
External Resources: FuncBase
Expression
cDNA source data(37)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase ttll1    NEW 
Molecular
reagents
All nucleic(40) Genomic(2) cDNA(37) Primer pair(1)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000023450 (Evidence)
Ensembl Gene Model ENSMUSG00000022442 (Evidence)
Entrez Gene 319953 (Evidence)
UniGene 235007
DFCI TC1763882, TC1575129, TC1762591, TC1593438
DoTS DT.94274442, DT.94274443, DT.485350, DT.91329215
NIA Mouse Gene Index U036477
EC 6.-.-.-
Consensus CDS Project CCDS27702.1
International Mouse Phenotyping Consortium Status Ttll1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023450 VEGA Gene Model | MGI Sequence Detail 27122 C57BL/6J ±  kb
transcript OTTMUST00000057014 VEGA | MGI Sequence Detail 2057 Not Applicable 
polypeptide OTTMUSP00000027458 VEGA | MGI Sequence Detail 423 Not Applicable 

For the selected sequences
All sequences(66) RefSeq(8) UniProt(3)
Polymorphisms
SNPs within 2kb(142 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004344 Tubulin-tyrosine ligase
Protein Ontology PR:000032221 tubulin polyglutamylase TTLL1
References
(Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(35)
Other
accession IDs
MGI:2146161

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory