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Taf2 Gene Detail
Summary
  • Symbol
    Taf2
  • Name
    TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor
  • Synonyms
    150kDa, 4732460C16Rik, CIF150, TAF2B, TAFII150
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443028
    NCBI Gene: 319944
Location & Maps
more
  • Sequence Map
    Chr15:55015129-55072152 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      57024 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    TAF2, TATA-box binding protein associated factor 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TAF2, TATA-box binding protein associated factor 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CIF150, MRT40, TAF2B, TAFII150
  • Links
    NCBI Gene ID: 6873
    neXtProt AC: NX_Q6P1X5

  • Chr Location
    8q24.12; chr8:119730773-119832858 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 31137
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: TAF2
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human TAF2 associations

Human Disease Mouse Models
       Mental Retardation, Autosomal Recessive 40; MRT40   OMIM: 615599
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    16 phenotype references
  • All Mutations and Alleles
    13
  • Chemically induced (other)
    3
  • Gene trapped
    4
  • Radiation induced
    1
  • Targeted
    5
  • Genomic Mutations
    4 involving Taf2
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000037343 Ensembl Gene Model | MGI Sequence Detail 57024 C57BL/6J ±  kb
transcript ENSMUST00000041733 Ensembl | MGI Sequence Detail 5033 Not Applicable  
polypeptide ENSMUSP00000043733 Ensembl | MGI Sequence Detail 1198 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    288 from dbSNP Build 137
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000016025 transcription initiation factor TFIID subunit 2
  • InterPro Domains
    IPR016024 Armadillo-type fold
    IPR014782 Peptidase M1, membrane alanine aminopeptidase, N-terminal
Molecular
Reagents
less
  • All nucleic 96
    cDNA 96

    Microarray probesets 2
Other
Accession IDs
less
MGI:2145997
References
more
  • Summaries
    All 30
    Developmental Gene Expression 3
    Diseases 1
    Gene Ontology 5
    Phenotypes 16
  • Earliest
    J:78343 Loebel DA, et al., Isolation of differentially expressed genes from wild-type and Twist mutant mouse limb buds. Genesis. 2002 Jul;33(3):103-13
  • Latest
    J:181994 Kamileri I, et al., Defective transcription initiation causes postnatal growth failure in a mouse model of nucleotide excision repair (NER) progeria. Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):2995-3000

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory