Adamts19 MGI Mouse Gene Detail - MGI:2442875 - a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 19

Symbol

Adamts19
Name

a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 19
Synonyms

D230034E10Rik

Feature Type

protein coding gene
IDs

MGI:2442875
NCBI Gene: 240322
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr18:58836667-59054060 bp, + strand
From Ensembl annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 18, 33.78 cM
Mapping Data

3 experiments

SNPs within 2kb

1505 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2442875	protein coding gene	Chr18:58835992-59054060 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0024455	protein coding gene	Chr18:58413112-58636075 (+)
A/J	MGP_AJ_G0024421	protein coding gene	Chr18:56031678-56245036 (+)
AKR/J	MGP_AKRJ_G0024391	protein coding gene	Chr18:57584836-57796983 (+)
BALB/cJ	MGP_BALBcJ_G0024421	protein coding gene	Chr18:56192522-56399551 (+)
C3H/HeJ	MGP_C3HHeJ_G0024188	protein coding gene	Chr18:57786362-58011969 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0024867	protein coding gene	Chr18:60214809-60443413 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022299	protein coding gene	Chr18:55592584-55787307 (+)
CAST/EiJ	MGP_CASTEiJ_G0023662	protein coding gene	Chr18:57812862-58030441 (+)
CBA/J	MGP_CBAJ_G0024158	protein coding gene	Chr18:62159740-62402608 (+)
DBA/2J	MGP_DBA2J_G0024288	protein coding gene	Chr18:55730501-55949769 (+)
FVB/NJ	MGP_FVBNJ_G0024255	protein coding gene	Chr18:55107127-55317573 (+)
LP/J	MGP_LPJ_G0024373	protein coding gene	Chr18:58329003-58547911 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024285	protein coding gene	Chr18:63677197-63908964 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024914	protein coding gene	Chr18:57697532-57926477 (+)
PWK/PhJ	MGP_PWKPhJ_G0023406	protein coding gene	Chr18:55762455-55970745 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023212	protein coding gene	Chr18:57787592-57995060 (+)
WSB/EiJ	MGP_WSBEiJ_G0023725	protein coding gene	Chr18:57606368-57824236 (+)

Human Ortholog

ADAMTS19, ADAM metallopeptidase with thrombospondin type 1 motif 19

Vertebrate Orthologs

8

Human Ortholog

ADAMTS19, ADAM metallopeptidase with thrombospondin type 1 motif 19
Orthology source: HomoloGene, HGNC
Links

HGNC:17111

NCBI Gene ID: 171019

neXtProt AC: NX_Q8TE59

UniProt: Q8TE59
Chr Location

5q23.3; chr5:129460281-129738683 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 15860
1 human;1 mouse;1 chimpanzee;1 cattle;1 dog;1 chicken;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: ADAMTS19
Gene Tree

Adamts19

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Targeted

6
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

36 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

12
GO References

3

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

877
Tissues

92
cDNA Data

19
Literature Summary

14

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA ADAMTS19

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Adamts19 interacts with 241 markers (Mir10a, Mir10b, Mir17, ...) View All

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All Sequences

56
RefSeq

18
UniProt

3
CCDS

CCDS29266.1
UniGene

71963

Ensembl

ENSMUSG00000053441 (Evidence)
NCBI Gene

240322

			Length	Strain/Species	Flank
genomic	ENSMUSG00000053441	Ensembl Gene Model \| MGI Sequence Detail	217394	C57BL/6J	± kb
transcript	ENSMUST00000052907	Ensembl \| MGI Sequence Detail	5145	Not Applicable
polypeptide	ENSMUSP00000050535	Ensembl \| MGI Sequence Detail	1210	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000029297 a disintegrin and metalloproteinase with thrombospondin motifs 19

(term hierarchy)
EC

3.4.24.-
InterPro Domains

IPR006586 ADAM, cysteine-rich domain

IPR041645 ADAM cysteine-rich domain 2

IPR013273 ADAMTS/ADAMTS-like

IPR010294 ADAM-TS Spacer 1

IPR024079 Metallopeptidase, catalytic domain superfamily

IPR001590 Peptidase M12B, ADAM/reprolysin

IPR002870 Peptidase M12B, propeptide

IPR010909 PLAC

IPR000884 Thrombospondin type-1 (TSP1) repeat

IPR036383 Thrombospondin type-1 (TSP1) repeat superfamily

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All nucleic 26

cDNA 20

Primer pair 5

Other 1

Microarray probesets 2

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MGI:2147293

Summaries

All 41

Developmental Gene Expression 14

Gene Ontology 3

Phenotypes 6
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:287334 Wunnemann F, et al., Loss of ADAMTS19 causes progressive non-syndromic heart valve disease. Nat Genet. 2020 Jan;52(1):40-47

TSS for Adamts19:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr151225	Chr18:58836152-58836182 (+)	-500 bp
Tssr151226	Chr18:58836184-58836209 (+)	-470 bp
Tssr151227	Chr18:58836321-58836339 (+)	-337 bp
Tssr151228	Chr18:58836350-58836374 (+)	-305 bp
Tssr151229	Chr18:58836382-58836396 (+)	-278 bp
Tssr151230	Chr18:58836721-58836751 (+)	69 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 10/13/2020 MGI 6.16