Adamts19 MGI Mouse Gene Detail - MGI:2442875 - a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 19

Adamts19 Gene Detail

Symbol

Adamts19
Name

a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 19
Synonyms

D230034E10Rik

Feature Type

protein coding gene
IDs

MGI:2442875
NCBI Gene: 240322

Sequence Map

Chr18:58836764-59053678 bp, + strand
From Ensembl annotation of GRCm38

Mouse Genome Browser
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Sequence

216915 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 18, 33.78 cM
Mapping Data

3 experiments

Human Ortholog

ADAMTS19, ADAM metallopeptidase with thrombospondin type 1 motif 19

Vertebrate Orthologs

8

Human Ortholog

ADAMTS19, ADAM metallopeptidase with thrombospondin type 1 motif 19
Orthology source: HomoloGene, HGNC
Links

HGNC:17111

NCBI Gene ID: 171019

neXtProt AC: NX_Q8TE59

UniProt: Q8TE59
Chr Location

5q23.3; chr5:129460281-129738683 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 15860
1 human;1 mouse;1 chimpanzee;1 cattle;1 dog;1 chicken;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: ADAMTS19
Gene Tree

Adamts19

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
5 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Targeted

5
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

32 strains or lines available

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All GO Annotations

12
GO References

2

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

175
Tissues

52
cDNA Data

18
Literature Summary

12

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA ADAMTS19

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Adamts19 interacts with 241 markers (Mir10a, Mir10b, Mir17, ...) View All

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All Sequences

34
RefSeq

17
UniProt

3
CCDS

CCDS29266.1
UniGene

71963

Ensembl

ENSMUSG00000053441 (Evidence)
NCBI Gene

240322

			Length	Strain/Species	Flank
genomic	ENSMUSG00000053441	Ensembl Gene Model \| MGI Sequence Detail	216915	C57BL/6J	± kb
transcript	ENSMUST00000052907	Ensembl \| MGI Sequence Detail	4666	Not Applicable
polypeptide	ENSMUSP00000050535	Ensembl \| MGI Sequence Detail	1210	Not Applicable

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SNPs within 2kb

1504 from dbSNP Build 142

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UniProt

3 Sequences
Protein Ontology

PR:000029297 a disintegrin and metalloproteinase with thrombospondin motifs 19

(term hierarchy)
EC

3.4.24.-
InterPro Domains

IPR006586 ADAM, cysteine-rich

IPR010294 ADAM-TS Spacer 1

IPR024079 Metallopeptidase, catalytic domain

IPR001590 Peptidase M12B, ADAM/reprolysin

IPR013273 Peptidase M12B, ADAM-TS

IPR002870 Peptidase M12B, propeptide

IPR010909 PLAC

IPR000884 Thrombospondin type-1 (TSP1) repeat

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All nucleic 23

cDNA 19

Primer pair 4

Microarray probesets 2

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MGI:2147293

Summaries

All 37

Developmental Gene Expression 12

Gene Ontology 2

Phenotypes 5
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:226028 Lewandowski JP, et al., Spatiotemporal regulation of GLI target genes in the mammalian limb bud. Dev Biol. 2015 Oct 1;406(1):92-103

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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