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Osbpl2 Gene Detail
Summary
  • Symbol
    Osbpl2
  • Name
    oxysterol binding protein-like 2
  • Synonyms
    C130070J12Rik, ORP-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442832
    NCBI Gene: 228983
  • Gene Overview
    MyGene.info: OSBPL2
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:180119366-180162682 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 102.64 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    230 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2442832
protein coding gene Chr2:180119306-180162682 (.)
129S1/SvImJ MGP_129S1SvImJ_G0026987
protein coding gene Chr2:186619839-186667219 (+)
A/J MGP_AJ_G0026953
protein coding gene Chr2:178952840-178997978 (+)
AKR/J MGP_AKRJ_G0026923
protein coding gene Chr2:184309727-184355475 (+)
BALB/cJ MGP_BALBcJ_G0026962
protein coding gene Chr2:179416981-179460792 (+)
C3H/HeJ MGP_C3HHeJ_G0026703
protein coding gene Chr2:184661884-184711142 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027408
protein coding gene Chr2:192012132-192058154 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024775
protein coding gene Chr2:169645700-169689222 (+)
CAST/EiJ MGP_CASTEiJ_G0026162
protein coding gene Chr2:182906688-182952294 (+)
CBA/J MGP_CBAJ_G0026680
protein coding gene Chr2:198993047-199043116 (+)
DBA/2J MGP_DBA2J_G0026818
protein coding gene Chr2:178048274-178100856 (+)
FVB/NJ MGP_FVBNJ_G0026784
protein coding gene Chr2:176652892-176697824 (+)
LP/J MGP_LPJ_G0026919
protein coding gene Chr2:186611743-186659200 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026803
protein coding gene Chr2:201621081-201667535 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027467
protein coding gene Chr2:184275164-184320467 (+)
PWK/PhJ MGP_PWKPhJ_G0025898
protein coding gene Chr2:175558936-175603221 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025698
protein coding gene Chr2:180762829-180808079 (+)
WSB/EiJ MGP_WSBEiJ_G0026234
protein coding gene Chr2:185240203-185285114 (+)



Homology
more
  • Human Ortholog
    OSBPL2, oxysterol binding protein like 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    OSBPL2, oxysterol binding protein like 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DFNA67, DNFA67, ORP2, ORP-2
  • Links
    NCBI Gene ID: 9885
    neXtProt AC: NX_Q9H1P3
    UniProt: Q9H1P3

  • Chr Location
    20q13.33; chr20:62238485-62296213 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human OSBPL2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 228983 NCBI Gene Model | MGI Sequence Detail 43317 C57BL/6J ±  kb
transcript NM_144500 RefSeq | MGI Sequence Detail 2807 C57BL/6  
polypeptide Q8BX94 UniProt | EBI | MGI Sequence Detail 484 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 75
    cDNA 74
    Primer pair 1

    Microarray probesets 3
References
more
  • Summaries
    All 31
    Developmental Gene Expression 2
    Gene Ontology 4
    Phenotypes 5
  • Earliest
    J:78568 Anniss AM, et al., An oxysterol-binding protein family identified in the mouse. DNA Cell Biol. 2002 Aug;21(8):571-80
  • Latest
    J:251030 Thoenes M, et al., OSBPL2 encodes a protein of inner and outer hair cell stereocilia and is mutated in autosomal dominant hearing loss (DFNA67). Orphanet J Rare Dis. 2015 Feb 10;10:15

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory