Osbpl2^em1Cya
Endonuclease-mediated Allele Detail

Summary

• Symbol: Osbpl2^em1Cya
• Name: oxysterol binding protein-like 2; endonuclease-mediated mutation 1, Cyagen Biosciences
• MGI ID: MGI:7331342
• Gene: Osbpl2 Location: Chr2:179761099-179804473 bp, + strand Genetic Position: Chr2, 102.64 cM
• Alliance: Osbpl2^em1Cya page

Mutation origin

• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR/Cas9 technology targeting the region flanking exon 3 and exon 4 generated a 3571 bp deletion. (J:324115)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Osbpl2 Mutation: 21 strains or lines available

References

• Original: J:324115 Shi H, et al., Mutations in OSBPL2 cause hearing loss associated with primary cilia defects via sonic hedgehog signaling. JCI Insight. 2022 Feb 22;7(4):e149626
• All: 1 reference(s)