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Mob1a Gene Detail
Summary
  • Symbol
    Mob1a
  • Name
    MOB kinase activator 1A
  • Synonyms
    4022402H07Rik, MGC:6884, Mobk1b, Mobkl1b
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442631
    NCBI Gene: 232157
  • Gene Overview
    MyGene.info: MOB1A
Location & Maps
more
  • Sequence Map
    Chr6:83326016-83343776 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      17761 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 35.94 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    MOB1A, MOB kinase activator 1A
  • Vertebrate Orthologs
    11
  • Human Ortholog
    MOB1A, MOB kinase activator 1A
    Orthology source: HGNC, HomoloGene
  • Synonyms
    C2orf6, MATS1, MOB1, Mob4B, MOBK1B, MOBKL1B
  • Links
    NCBI Gene ID: 55233
    neXtProt AC: NX_Q9H8S9

  • Chr Location
    2p13.1; chr2:74154409-74178886 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 10076
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: MOB1A
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    35 phenotypes from multigenic genotypes
    6 images
    6 phenotype references
  • All Mutations and Alleles
    8
  • Gene trapped
    3
  • Spontaneous
    1
  • Targeted
    4
  • Genomic Mutations
    1 involving Mob1a
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit no abnormal phenotype.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022699 VEGA Gene Model | MGI Sequence Detail 17761 C57BL/6J ±  kb
transcript OTTMUST00000054461 VEGA | MGI Sequence Detail 2292 Not Applicable  
polypeptide OTTMUSP00000025996 VEGA | MGI Sequence Detail 216 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    70 from dbSNP Build 142
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000010505 MOB kinase activator 1A
  • InterPro Domains
    IPR005301 MOB kinase activator family
Molecular
Reagents
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  • All nucleic 274
    cDNA 274

    Microarray probesets 7
References
more
  • Summaries
    All 25
    Gene Ontology 2
    Phenotypes 6
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:193981 Nishio M, et al., Cancer susceptibility and embryonic lethality in Mob1a/1b double-mutant mice. J Clin Invest. 2012 Dec 3;122(12):4505-18

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory