Rnf43
Gene Detail

Symbol Name ID

Rnf43 ring finger protein 43 MGI:2442609

Synonyms

4732452J19Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 11

52.17 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr11:87662722-87735539 bp, + strand From VEGA annotation of GRCm38   72818 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:37742  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Gene Tree: Rnf43

Human homologs

Human Homolog		RNF43, ring finger protein 43
NCBI Gene ID		54894
neXtProt AC		NX_Q68DV7
Human Synonyms		RNF124, URCC
Human Chr (Location)		17q22; chr17:56431037-56494931 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(2) : Targeted(2)

Gene Ontology (GO) classifications

All GO classifications: (18 annotations)

Process	negative regulation of Wnt receptor signaling pathway, protein ubiquitination, ...
Component	endoplasmic reticulum, integral to membrane, ...
Function	frizzled binding, ligase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (5 records)
Data Summary: Results (83)    Tissues (31)    Images (30)
Theiler Stages: 17, 18, 22, 23, 28

Assay Type	Results
RNA in situ	83

cDNA source data(12)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(12) cDNA(12)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000001292 (Evidence)
Ensembl Gene Model	ENSMUSG00000034177 (Evidence)
Entrez Gene	207742 (Evidence)
DFCI	TC1583152, TC1593366, TC1656419, TC1728983
NIA Mouse Gene Index	U013145
EC	6.3.2.-
Consensus CDS Project	CCDS25215.2
International Mouse Knockout Project Status	Rnf43

Sequences

Length	Strain/Species
genomic	OTTMUSG00000001292	VEGA Gene Model | MGI Sequence Detail	72818	C57BL/6J
transcript	OTTMUST00000002595	VEGA | MGI Sequence Detail	4037	Not Applicable
polypeptide	OTTMUSP00000001287	VEGA | MGI Sequence Detail	784	Not Applicable

All sequences(52) RefSeq(2) UniProt(4)

Polymorphisms

SNPs(37 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR013083	Zinc finger, RING/FYVE/PHD-type
InterPro	IPR001841	Zinc finger, RING-type
Protein Ontology	PR:000014137	RING finger protein 43

References

(Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:186765 Koo BK, et al., Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors. Nature. 2012 Aug 30;488(7413):665-9
All references(28)