Kdm4b
Gene Detail

Symbol Name ID

Kdm4b lysine (K)-specific demethylase 4B MGI:2442355

Synonyms

4732474L06Rik, Jmjd2b, MGC:6349, mKIAA0876

Feature Type

protein coding gene

Genetic Map

Chromosome 17

29.27 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr17:56326062-56402870 bp, + strand From VEGA annotation of GRCm38   76809 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:27773  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Kdm4b

Human homologs

Human Homolog		KDM4B, lysine (K)-specific demethylase 4B
NCBI Gene ID		23030
neXtProt AC		NX_O94953
Human Synonyms		JMJD2B, TDRD14B
Human Chr (Location)		19p13.3; chr19:4969124-5153609 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(15) : Targeted(4) Gene trapped(11)
 

Mice homozygous for a targeted allele lacking demethylase activity exhibit no gross abnormalities. Mice homozygous for a conditional allele activated in mammary gland epithelial cells exhibit delayed mammary gland development with reduced branching.

 

Gene Ontology (GO) classifications

All GO classifications: (9 annotations)

Process	chromatin modification, oxidation-reduction process, ...
Component	nucleus
Function	metal ion binding, oxidoreductase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (6 records)
Data Summary: Results (191)    Tissues (82)    Images (29)
Theiler Stages: 1, 2, 3, 4, 5, 17, 21, 23, 28

Assay Type	Results
RNA in situ	148
RT-PCR	43

cDNA source data(118)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(120) cDNA(118) Primer pair(2)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000024381 (Evidence)
Ensembl Gene Model	ENSMUSG00000024201 (Evidence)
Entrez Gene	193796 (Evidence)
UniGene	45047
DFCI	TC1575456, TC1604906, TC1622949, TC1753644, TC1766610
DoTS	DT.101189217, DT.101325894, DT.101401035, DT.530340, DT.94218589, DT.97407194
NIA Mouse Gene Index	U043614
EC	1.14.11.-
Consensus CDS Project	CCDS28904.1
International Mouse Knockout Project Status	Kdm4b

Sequences

Length	Strain/Species
genomic	OTTMUSG00000024381	VEGA Gene Model | MGI Sequence Detail	76809	C57BL/6J
transcript	OTTMUST00000059734	VEGA | MGI Sequence Detail	4577	Not Applicable
polypeptide	OTTMUSP00000029076	VEGA | MGI Sequence Detail	1086	Not Applicable

All sequences(67) RefSeq(2) UniProt(7)

Polymorphisms

SNPs(3 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR003347	JmjC domain
InterPro	IPR003349	Transcription factor jumonji, JmjN
InterPro	IPR002999	Tudor domain
InterPro	IPR001965	Zinc finger, PHD-type
InterPro	IPR013083	Zinc finger, RING/FYVE/PHD-type
Protein Ontology	PR:000009214	JmjC domain-containing histone demethylation protein 3B

References

(Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:183406 Mallette FA, et al., RNF8- and RNF168-dependent degradation of KDM4A/JMJD2A triggers 53BP1 recruitment to DNA damage sites. EMBO J. 2012 Apr 18;31(8):1865-78
All references(45)