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Kdm4b Gene Detail
Summary
  • Symbol
    Kdm4b
  • Name
    lysine (K)-specific demethylase 4B
  • Synonyms
    4732474L06Rik, Jmjd2b, MGC:6349, mKIAA0876
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442355
    NCBI Gene: 193796
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:56633062-56709870 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 29.27 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1607 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2442355
 protein coding gene Chr17:56632975-56710774 (+)
129S1/SvImJ ENSMUSG00200016062
 protein coding gene Chr17:51933753-51985030 (+)
A/J ENSMUSG00195007055
 protein coding gene Chr17:53321198-53372432 (+)
AKR/J ENSMUSG00220012762
 protein coding gene Chr17:52370554-52421782 (+)
BALB/cJ ENSMUSG00180005344
 protein coding gene Chr17:53078813-53130047 (+)
C3H/HeJ ENSMUSG00175007395
 protein coding gene Chr17:52394871-52446101 (+)
C57BL/6NJ ENSMUSG00215007819
 protein coding gene Chr17:52008993-52060224 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021776
 protein coding gene Chr17:52912480-52989860 (+)
CAST/EiJ ENSTCUG00005018971
 protein coding gene Chr17:53125179-53176359 (+)
CBA/J ENSMUSG00210027786
 protein coding gene Chr17:52161933-52213166 (+)
DBA/2J ENSMUSG00185009172
 protein coding gene Chr17:55031766-55083004 (+)
FVB/NJ ENSMUSG00205007018
 protein coding gene Chr17:52709453-52760729 (+)
JF1/MsJ ENSUMUG00000020094
 protein coding gene Chr17:54710686-54762172 (+)
LP/J ENSMUSG00230025156
 protein coding gene Chr17:56011131-56062408 (+)
NOD/ShiLtJ ENSMUSG00190009575
 protein coding gene Chr17:52164664-52215943 (+)
NZO/HlLtJ ENSMUSG00225042313
 protein coding gene Chr17:58294990-58346221 (+)
PWK/PhJ ENSLUMG00010009338
 protein coding gene Chr17:51969614-52020876 (+)
SPRET/EiJ ENSMSPG00010005036
 protein coding gene Chr17:52258650-52334831 (+)
WSB/EiJ ENSIUOG00005023154
 protein coding gene Chr17:53070747-53122021 (+)



Homology
more
  • Human Ortholog
    KDM4B, lysine demethylase 4B
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KDM4B, lysine demethylase 4B
  • Synonyms
    JMJD2B, MRD65, TDRD14B
  • Links
    NCBI Gene ID: 23030
    UniProt: O94953

  • Chr Location
    19p13.3; chr19:4969107-5153611 (+)  GRCh38
Human Diseases
more
  • Diseases
    5 with human KDM4B associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 3 alleles in 3 genetic backgrounds
    1 images
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted allele lacking demethylase activity exhibit no gross abnormalities. Mice homozygous for a conditional allele activated in mammary gland epithelial cells exhibit delayed mammary gland development with reduced branching.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    24
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    836
  • Tissues
    106
  • cDNA Data
    121
  • Literature Summary
    14
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024201 Ensembl Gene Model | MGI Sequence Detail 76809 C57BL/6J ±  kb
    transcript ENSMUST00000025036 Ensembl | MGI Sequence Detail 4577 Not Applicable  
    polypeptide ENSMUSP00000025036 Ensembl | MGI Sequence Detail 1086 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 126
      cDNA 121
      Primer pair 5
      Antibodies 2

      Microarray probesets 3
    References
    more
    • Summaries
      All 76
      Developmental Gene Expression 14
      Gene Ontology 11
      Phenotypes 24
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:367355 Peng Z, et al., KDM4B modulates autocrine IL6 in erythroblasts to prevent ineffective erythropoiesis. Leukemia. 2025 May;39(5):1228-1242
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory