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Kdm4b Gene Detail
Summary
  • Symbol
    Kdm4b
  • Name
    lysine (K)-specific demethylase 4B
  • Synonyms
    4732474L06Rik, Jmjd2b, MGC:6349, mKIAA0876
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442355
    NCBI Gene: 193796
  • Gene Overview
    MyGene.info: KDM4B
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr17:56326062-56402870 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      76809 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 29.27 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    KDM4B, lysine demethylase 4B
  • Vertebrate Orthologs
    10
  • Human Ortholog
    KDM4B, lysine demethylase 4B
    Orthology source: HGNC, HomoloGene
  • Synonyms
    JMJD2B, TDRD14B
  • Links
    NCBI Gene ID: 23030
    neXtProt AC: NX_O94953
    UniProt: O94953

  • Chr Location
    19p13.3; chr19:4969112-5153603 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 27773
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: KDM4B
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 3 alleles in 3 genetic backgrounds
    1 images
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted allele lacking demethylase activity exhibit no gross abnormalities. Mice homozygous for a conditional allele activated in mammary gland epithelial cells exhibit delayed mammary gland development with reduced branching.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000024381 VEGA Gene Model | MGI Sequence Detail 76809 C57BL/6J ±  kb
    transcript OTTMUST00000059734 VEGA | MGI Sequence Detail 4577 Not Applicable  
    polypeptide OTTMUSP00000029076 VEGA | MGI Sequence Detail 1086 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      15 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 126
      cDNA 121
      Primer pair 5

      Microarray probesets 3
    References
    more
    • Summaries
      All 54
      Developmental Gene Expression 10
      Gene Ontology 6
      Phenotypes 13
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:262875 Cheng Y, et al., KDM4B protects against obesity and metabolic dysfunction. Proc Natl Acad Sci U S A. 2018 Jun 12;115(24):E5566-E5575

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    09/11/2018
    MGI 6.12
    The Jackson Laboratory