About   Help   FAQ
Kdm4b
Gene Detail
Symbol

Name
ID
Kdm4b
lysine (K)-specific demethylase 4B
MGI:2442355
Synonyms
4732474L06Rik, Jmjd2b, MGC:6349, mKIAA0876
Feature Type
protein coding gene
Genetic Map
Chromosome 17
29.27 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr17:56326062-56402870 bp, + strand
From VEGA annotation of GRCm38

  76809 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:27773  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: KDM4B
Gene Tree: Kdm4b

Human
homologs
KDM4B, lysine (K)-specific demethylase 4B
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 23030
neXtProt AC: NX_O94953

Human Synonyms: JMJD2B, TDRD14B

Human Chr (Location): 19p13.3; chr19:4969112-5153598 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(15) : Gene trapped(11) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a targeted allele lacking demethylase activity exhibit no gross abnormalities. Mice homozygous for a conditional allele activated in mammary gland epithelial cells exhibit delayed mammary gland development with reduced branching.
 
Interactions
Kdm4b interacts with 164 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (7 records)
Data Summary: Results (172)    Tissues (76)    Images (29)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 148
RT-PCR 24
cDNA source data(118)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase kdm4b    NEW 
Molecular
reagents
All nucleic(120) cDNA(118) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000024381 (Evidence)
Ensembl Gene Model ENSMUSG00000024201 (Evidence)
Entrez Gene 193796 (Evidence)
UniGene 45047
DFCI TC1753644, TC1622949, TC1766610, TC1604906, TC1575456
DoTS DT.530340, DT.101401035, DT.97407194, DT.94218589, DT.101325894, DT.101189217
NIA Mouse Gene Index U043614
EC 1.14.11.-
Consensus CDS Project CCDS28904.1
International Mouse Phenotyping Consortium Status Kdm4b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024381 VEGA Gene Model | MGI Sequence Detail 76809 C57BL/6J ±  kb
transcript OTTMUST00000059734 VEGA | MGI Sequence Detail 4577 Not Applicable 
polypeptide OTTMUSP00000029076 VEGA | MGI Sequence Detail 1086 Not Applicable 

For the selected sequences
All sequences(80) RefSeq(16) UniProt(6)
Polymorphisms
SNPs within 2kb(15 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003347 JmjC domain
InterPro IPR003349 Transcription factor jumonji, JmjN
InterPro IPR002999 Tudor domain
InterPro IPR011011 Zinc finger, FYVE/PHD-type
InterPro IPR001965 Zinc finger, PHD-type
InterPro IPR013083 Zinc finger, RING/FYVE/PHD-type
Protein Ontology PR:000009214 lysine-specific demethylase 4B
References
(Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:205909 Das PP, et al., Distinct and combinatorial functions of Jmjd2b/Kdm4b and Jmjd2c/Kdm4c in mouse embryonic stem cell identity. Mol Cell. 2014 Jan 9;53(1):32-48
All references(50)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/23/2015
MGI 5.22
The Jackson Laboratory