Kdm4b Phenotype Annotations

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Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Kdm4b
lysine (K)-specific demethylase 4B
MGI:2442355

14 phenotypes from 3 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Kdm4b^tm1.1Okad/Kdm4b^tm1.1Okad involves: 129P2/OlaHsd	no abnormal phenotype detected	J:171678
Kdm4b^tm1.1Okad/Kdm4b^tm1.1Okad involves: 129P2/OlaHsd	decreased mammary gland epithelial cell proliferation	J:171678
Kdm4b^tm1.1Okad/Kdm4b^tm1.1Okad Tg(MMTV-cre)1Mam/0 involves: 129P2/OlaHsd * FVB	abnormal branching of the mammary ductal tree	J:171678
	abnormal mammary gland development	J:171678
Kdm4b^tm1.2Okad/Kdm4b^tm1.2Okad involves: 129P2/OlaHsd	no abnormal phenotype detected	J:171678
Kdm4b^{tm1a(EUCOMM)Wtsi}/Kdm4b⁺ B6Dnk;B6Brd;B6N-Tyr^c-Brd Kdm4b^{tm1a(EUCOMM)Wtsi}/WtsiH	abnormal behavior	J:175295
	abnormal brain size	J:302280
	absent corpus callosum	J:302280
	decreased circulating total protein level	J:175295
	decreased dentate gyrus size	J:302280
	enlarged lateral ventricles	J:302280
	increased body length	J:175295
	increased circulating creatinine level	J:175295
Kdm4b^{tm1a(EUCOMM)Wtsi}/Kdm4b^{tm1a(EUCOMM)Wtsi} B6Dnk;B6Brd;B6N-Tyr^c-Brd Kdm4b^{tm1a(EUCOMM)Wtsi}/WtsiH	lethality throughout fetal growth and development, incomplete penetrance	J:302280
	preweaning lethality, incomplete penetrance	J:211773, J:302280

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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