Fancm MGI Mouse Gene Detail - MGI:2442306 - Fanconi anemia, complementation group M

Symbol

Fancm
Name

Fanconi anemia, complementation group M
Synonyms

C730036B14Rik, D12Ertd364e

Feature Type

protein coding gene
IDs

MGI:2442306
NCBI Gene: 104806
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr12:65122377-65178832 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 27.21 cM
Mapping Data

3 experiments

SNPs within 2kb

308 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2442306	protein coding gene	Chr12:65120884-65178832 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019780	protein coding gene	Chr12:64559243-64615453 (+)
A/J	MGP_AJ_G0019739	protein coding gene	Chr12:62173828-62231446 (+)
AKR/J	MGP_AKRJ_G0019714	protein coding gene	Chr12:64153019-64209749 (+)
BALB/cJ	MGP_BALBcJ_G0019719	protein coding gene	Chr12:62615136-62671311 (+)
C3H/HeJ	MGP_C3HHeJ_G0019524	protein coding gene	Chr12:64499087-64556070 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020171	protein coding gene	Chr12:66596707-66654634 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017791	protein coding gene	Chr12:59989814-60047026 (+)
CAST/EiJ	MGP_CASTEiJ_G0019076	protein coding gene	Chr12:59205814-59268399 (+)
CBA/J	MGP_CBAJ_G0019493	protein coding gene	Chr12:69018489-69078895 (+)
DBA/2J	MGP_DBA2J_G0019609	protein coding gene	Chr12:62101667-62157837 (+)
FVB/NJ	MGP_FVBNJ_G0019597	protein coding gene	Chr12:61127887-61184414 (+)
LP/J	MGP_LPJ_G0019681	protein coding gene	Chr12:64577495-64635378 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019635	protein coding gene	Chr12:71885455-71944873 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020205	protein coding gene	Chr12:63540300-63597334 (+)
PWK/PhJ	MGP_PWKPhJ_G0018842	protein coding gene	Chr12:56375273-56433237 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018636	protein coding gene	Chr12:57863265-57922585 (+)
WSB/EiJ	MGP_WSBEiJ_G0019127	protein coding gene	Chr12:64071804-64130714 (+)

Human Ortholog

FANCM, FA complementation group M

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FANCM, FA complementation group M
Synonyms

FAAP250, KIAA1596, POF15, SPGF28
Links

HGNC:23168

NCBI Gene ID: 57697

neXtProt AC: NX_Q8IYD8

UniProt: Q8IYD8
Chr Location

14q21.2; chr14:45135930-45200890 (+) GRCh38

MGI Vertebrate Homology

Fancm stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: FANCM
Gene Tree

Fancm

Diseases

2 with human FANCM associations

				Human Disease	Mouse Models
				primary ovarian insufficiency 15 IDs primary ovarian insufficiency 15 DOID:0080872 OMIM:618096
				spermatogenic failure 28 IDs spermatogenic failure 28 DOID:0111916 OMIM:618086

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

19 phenotypes from 2 alleles in 2 genetic backgrounds
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

19
Chemically induced (ENU)

1
Chemically induced (other)

1
Endonuclease-mediated

4
Gene trapped

9
Targeted

4
Genomic Mutations

1 involving Fancm
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

119 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit reduced female transmission, hypogonadism, premature death, and increased incidence of tumors. Homozygosity for a different KO results in male sterility.

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All GO Annotations

28
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

743
Tissues

3
cDNA Data

57
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase fancm

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All Sequences

70
RefSeq

8
UniProt

9
CCDS

CCDS25941.1

Ensembl

ENSMUSG00000055884 (Evidence)
NCBI Gene

104806

			Length	Strain/Species	Flank
genomic	ENSMUSG00000055884	Ensembl Gene Model \| MGI Sequence Detail	56456	C57BL/6J	± kb
transcript	ENSMUST00000058889	Ensembl \| MGI Sequence Detail	7775	Not Applicable
polypeptide	ENSMUSP00000054797	Ensembl \| MGI Sequence Detail	2021	Not Applicable

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UniProt

9 Sequences
Protein Ontology

PR:000007339 Fanconi anemia group M protein

(term hierarchy)
EC

3.6.4.13
InterPro Domains

IPR011545 DEAD/DEAH box helicase domain

IPR006166 ERCC4 domain

IPR044749 FANCM, DEAH-box helicase domain

IPR039686 FANCM/Mph1-like, insert domain

IPR031879 Fanconi anemia group M protein, MHF binding domain

IPR047418 Fanconi anemia group M protein, XPF-like nuclease domain

IPR001650 Helicase, C-terminal domain-like

IPR014001 Helicase superfamily 1/2, ATP-binding domain

IPR027417 P-loop containing nucleoside triphosphate hydrolase

IPR011335 Restriction endonuclease type II-like

IPR010994 RuvA domain 2-like

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All nucleic 58

cDNA 57

Primer pair 1

Microarray probesets 6

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MGI:1196390, MGI:2144812

Summaries

All 47

Developmental Gene Expression 1

Gene Ontology 9

Phenotypes 14
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:307167 Bloom JC, et al., Sexually dimorphic DNA damage responses and mutation avoidance in the mouse germline. Genes Dev. 2020 Dec 1;34(23-24):1637-1649

TSS for Fancm:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr113605	Chr12:65122356-65122391 (+)	-3 bp
Tssr113606	Chr12:65159863-65159878 (+)	37,494 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23