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Fancm
Gene Detail
 Symbol
Name
ID
Fancm
Fanconi anemia, complementation group M
MGI:2442306
Synonyms C730036B14Rik, D12Ertd364e
Feature Type protein coding gene
Genetic Map
Chromosome 12
27.21 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr12:65075606-65132058 bp, + strand
From NCBI annotation of GRCm38

  56453 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:35378  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Gene Tree: Fancm

Human
homologs
Human Homolog FANCM, Fanconi anemia, complementation group M
NCBI Gene ID 57697
neXtProt AC  NX_Q8IYD8
Human Synonyms  FAAP250, KIAA1596
Human Chr (Location)  14q21.2; chr14:45135933-45200890 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human FANCM
Alleles
and
phenotypes
All alleles(39) : Gene trapped(35) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit reduced female transmission, hypogonadism, premature death, and increased incidence of tumors.
 
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process cellular response to DNA damage stimulus, DNA metabolic process, ...
Component FANCM-MHF complex, Fanconi anaemia nuclear complex, ...
Function ATP binding, chromatin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (37)    Tissues (3)    Images (23)
Theiler Stages: 23
Assay TypeResults
RNA in situ 37
cDNA source data(56)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(57) cDNA(56) Primer pair(1)
Microarray probesets(6)
Other database
links
Ensembl Gene ModelENSMUSG00000055884 (Evidence)
Entrez Gene104806 (Evidence)
UniGene374847
DFCITC1583028, TC1585410, TC1593831, TC1597085, TC1601305, TC1615843, TC1633189
DoTSDT.101724042, DT.102544352, DT.102553839, DT.55256531, DT.91365775, DT.91564897, DT.94285872, DT.97367196
NIA Mouse Gene IndexU014001
EC3.6.4.13
Consensus CDS ProjectCCDS25941.1
International Mouse Knockout Project StatusFancm
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 104806 NCBI Gene Model | MGI Sequence Detail 56453 C57BL/6J ±  kb
transcript NM_178912 RefSeq | MGI Sequence Detail 7775 C57BL/6 
polypeptide Q8BGE5 UniProt | EBI | MGI Sequence Detail 2021 Not Applicable 

For the selected sequences
All sequences(56) RefSeq(12) UniProt(5)
Polymorphisms SNPs within 2kb(310 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR020819 DNA repair nuclease, XPF-type/Helicase
InterPro IPR011545 DNA/RNA helicase, DEAD/DEAH box type, N-terminal
InterPro IPR006166 ERCC4 domain
InterPro IPR001650 Helicase, C-terminal
InterPro IPR014001 Helicase, superfamily 1/2, ATP-binding domain
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR011335 Restriction endonuclease type II-like
InterPro IPR010994 RuvA domain 2-like
Protein Ontology PR:000007339 Fanconi anemia group M protein
Graphical View of Protein Domain Structure
References (Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(35)
Other
accession IDs
MGI:1196390, MGI:2144812

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory