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Gak Gene Detail
Summary
  • Symbol
    Gak
  • Name
    cyclin G associated kinase
  • Synonyms
    D130045N16Rik, MGC:31204
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442153
    NCBI Gene: 231580
  • Gene Overview
    MyGene.info: GAK
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:108569411-108629755 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 53.20 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    471 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2442153
protein coding gene Chr5:108569107-108629777 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029859
protein coding gene Chr5:110691826-110758992 (-)
A/J MGP_AJ_G0029823
protein coding gene Chr5:106435546-106496197 (-)
AKR/J MGP_AKRJ_G0029768
protein coding gene Chr5:109861678-109925884 (-)
BALB/cJ MGP_BALBcJ_G0029835
protein coding gene Chr5:107574953-107635884 (-)
C3H/HeJ MGP_C3HHeJ_G0029557
protein coding gene Chr5:110360116-110428230 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030289
protein coding gene Chr5:115210837-115277714 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027523
protein coding gene Chr5:101449355-101512817 (-)
CAST/EiJ MGP_CASTEiJ_G0028971
protein coding gene Chr5:109249175-109311756 (-)
CBA/J MGP_CBAJ_G0029525
protein coding gene Chr5:119099833-119168862 (-)
DBA/2J MGP_DBA2J_G0029671
protein coding gene Chr5:106563007-106623908 (-)
FVB/NJ MGP_FVBNJ_G0029628
protein coding gene Chr5:105290000-105354023 (-)
LP/J MGP_LPJ_G0029759
protein coding gene Chr5:111274785-111337582 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029660
protein coding gene Chr5:123990063-124054076 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030323
protein coding gene Chr5:109419203-109479231 (-)
PWK/PhJ MGP_PWKPhJ_G0028684
protein coding gene Chr5:105383770-105445986 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028522
protein coding gene Chr5:106946841-107010847 (-)
WSB/EiJ MGP_WSBEiJ_G0029044
protein coding gene Chr5:109739440-109802967 (-)



Homology
more
  • Human Ortholog
    GAK, cyclin G associated kinase
  • Vertebrate Orthologs
    11
  • Human Ortholog
    GAK, cyclin G associated kinase
    Orthology source: HGNC, HomoloGene
  • Synonyms
    DNAJ26, DNAJC26
  • Links
    NCBI Gene ID: 2580
    neXtProt AC: NX_O14976
    UniProt: O14976

  • Chr Location
    4p16.3; chr4:849275-932390 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    30 phenotypes from 3 alleles in 5 genetic backgrounds
    3 images
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a deletion of the kinase domain display neonatal lethality with abnormal lung alveolar morphology and development. Mice homozygous for a knock-out allele exhibit lethality during early development.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000062234 Ensembl Gene Model | MGI Sequence Detail 60345 C57BL/6J ±  kb
    transcript ENSMUST00000046603 Ensembl | MGI Sequence Detail 4453 Not Applicable  
    polypeptide ENSMUSP00000036705 Ensembl | MGI Sequence Detail 1305 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 149
      cDNA 149

      Microarray probesets 5
    References
    more
    • Summaries
      All 42
      Developmental Gene Expression 4
      Gene Ontology 10
      Phenotypes 13
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:225348 Park BC, et al., The clathrin-binding and J-domains of GAK support the uncoating and chaperoning of clathrin by Hsc70 in the brain. J Cell Sci. 2015 Oct 15;128(20):3811-21

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    12/11/2018
    MGI 6.13
    The Jackson Laboratory