About   Help   FAQ
Gak
Gene Detail
 Symbol
Name
ID
Gak
cyclin G associated kinase
MGI:2442153
Synonyms D130045N16Rik, MGC:31204
Feature Type protein coding gene
Genetic Map
Chromosome 5
53.20 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr5:108569411-108629739 bp, - strand
From VEGA annotation of GRCm38

  60329 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3846  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: auxilin/cyclin G-associated kinase
Gene Tree: Gak

Human
homologs
Human Homolog GAK, cyclin G associated kinase
NCBI Gene ID 2580
neXtProt AC  NX_O14976
Human Synonyms  DNAJ26, DNAJC26
Human Chr (Location)  4p16; chr4:849277-932390 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(5) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a deletion of the kinase domain display neonatal lethality with abnormal lung alveolar morphology and development. Mice homozygous for a knock-out allele exhibit lethality during early development.
 
Phenotype Images(3)
Interactions
Gak interacts with 377 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (30 annotations)
Process cell cycle, cell development, ...
Component cell junction, cytoplasm, ...
Function ATP binding, cyclin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (45)    Tissues (36)    Images (8)
Theiler Stages: 19, 20, 22, 23, 24, 26, 28
Assay TypeResults
RNA in situ 45
cDNA source data(147)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(148) cDNA(148)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000027010 (Evidence)
Ensembl Gene ModelENSMUSG00000062234 (Evidence)
Entrez Gene231580 (Evidence)
UniGene276647
DFCITC1573377, TC1593127, TC1604593, TC1615151, TC1631207, TC1689735, TC1706724
DoTSDT.101257636, DT.101308948, DT.101341272, DT.103571328, DT.110668865, DT.110668941, DT.110668969, DT.60118670, DT.91291245, DT.97396523
NIA Mouse Gene IndexU026533, U247676
EC2.7.11.1
Consensus CDS ProjectCCDS19513.1
International Mouse Knockout Project StatusGak
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027010 VEGA Gene Model | MGI Sequence Detail 60329 C57BL/6J ±  kb
transcript OTTMUST00000066768 VEGA | MGI Sequence Detail 4453 Not Applicable 
polypeptide OTTMUSP00000033506 VEGA | MGI Sequence Detail 1305 Not Applicable 

For the selected sequences
All sequences(104) RefSeq(13) UniProt(6)
Polymorphisms SNPs within 2kb(471 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000008 C2 calcium-dependent membrane targeting
InterPro IPR001623 DnaJ domain
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
InterPro IPR014020 Tensin phosphatase, C2 domain
Protein Ontology PR:000007805 cyclin-G-associated kinase
References (Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:179585 Tabara H, et al., Neonatal lethality in knockout mice expressing the kinase-dead form of the gefitinib target GAK is caused by pulmonary dysfunction. PLoS One. 2011;6(10):e26034
All references(39)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/19/2014
MGI 5.19
The Jackson Laboratory