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Adgrl3 Gene Detail
Summary
  • Symbol
    Adgrl3
  • Name
    adhesion G protein-coupled receptor L3
  • Synonyms
    5430402I23Rik, D130075K09Rik, LEC3, lectomedin 3, Lphn3, mKIAA0768
  • Feature Type
    protein coding gene
  • IDs
    MGI:2441950
    NCBI Gene: 319387
  • Gene Overview
    MyGene.info: ADGRL3
  • Alliance
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:81020138-81825133 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 42.62 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    4861 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2441950
protein coding gene Chr5:81019560-81827825 (.)
129S1/SvImJ MGP_129S1SvImJ_G0029660
protein coding gene Chr5:81594703-82425686 (+)
A/J MGP_AJ_G0029628
protein coding gene Chr5:78301617-79084566 (+)
AKR/J MGP_AKRJ_G0029576
protein coding gene Chr5:80914372-81732773 (+)
BALB/cJ MGP_BALBcJ_G0029637
protein coding gene Chr5:79134427-79940513 (+)
C3H/HeJ MGP_C3HHeJ_G0029360
protein coding gene Chr5:81406570-82233322 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030091
protein coding gene Chr5:84915654-85800679 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027333
protein coding gene Chr5:74469571-75230102 (+)
CAST/EiJ MGP_CASTEiJ_G0028768
protein coding gene Chr5:80584701-81406643 (+)
CBA/J MGP_CBAJ_G0029329
protein coding gene Chr5:87614490-88520680 (+)
DBA/2J MGP_DBA2J_G0029474
protein coding gene Chr5:78441664-79241862 (+)
FVB/NJ MGP_FVBNJ_G0029435
protein coding gene Chr5:77520459-78319066 (+)
LP/J MGP_LPJ_G0029561
protein coding gene Chr5:81956671-82808002 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029463
protein coding gene Chr5:91307395-92288856 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030124
protein coding gene Chr5:80518107-81318695 (+)
PWK/PhJ MGP_PWKPhJ_G0028492
protein coding gene Chr5:77451836-78252419 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028326
protein coding gene Chr5:79835690-80662219 (+)
WSB/EiJ MGP_WSBEiJ_G0028849
protein coding gene Chr5:80784507-81613434 (+)



Homology
more
  • Human Ortholog
    ADGRL3, adhesion G protein-coupled receptor L3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ADGRL3, adhesion G protein-coupled receptor L3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CIRL3, CL3, LEC3, LPHN3
  • Links
    NCBI Gene ID: 23284
    neXtProt AC: NX_Q9HAR2
    UniProt: Q9HAR2

  • Chr Location
    4q13.1; chr4:61201256-62078335 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 3 alleles in 3 genetic backgrounds
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap allele exhibit increased dopamine and serotonine levels in the dorsal striatum, hyperactivity, increased stereotypic behavior and enhanced hyperactivity in response to cocaine.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000037605 Ensembl Gene Model | MGI Sequence Detail 804996 C57BL/6J ±  kb
transcript ENSMUST00000120673 Ensembl | MGI Sequence Detail 5178 Not Applicable  
polypeptide ENSMUSP00000113482 Ensembl | MGI Sequence Detail 1580 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 15
    cDNA 15

    Microarray probesets 2
Other
Accession IDs
less
MGI:1921745
References
more
  • Summaries
    All 49
    Gene Ontology 11
    Phenotypes 19
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:259247 Orsini CA, et al., Behavioral and transcriptomic profiling of mice null for Lphn3, a gene implicated in ADHD and addiction. Mol Genet Genomic Med. 2016 May;4(3):322-43

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory