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Lphn3
Gene Detail
 Symbol
Name
ID
Lphn3
latrophilin 3
MGI:2441950
Synonyms 5430402I23Rik, D130075K09Rik, LEC3, lectomedin 3, mKIAA0768
Feature Type protein coding gene
Genetic Map
Chromosome 5
42.62 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr5:81020138-81825133 bp, + strand
From VEGA annotation of GRCm38

  804996 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:22878  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: alpha-latrotoxin receptor, calcium-independent type
Gene Tree: Lphn3

Human
homologs
Human Homolog LPHN3, latrophilin 3
NCBI Gene ID 23284
neXtProt AC  NX_Q9HAR2
Human Synonyms  CIRL3, LEC3
Human Chr (Location)  4q13.1; chr4:61497121-62072450 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(3) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a gene trap allele exhibit increased dopamine and serotonine levels in the dorsal striatum, hyperactivity, increased stereotypic behavior and enhanced hyperactivity in response to cocaine.
 
Interactions
Lphn3 interacts with 553 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process cell surface receptor signaling pathway, G-protein coupled receptor signaling pathway, ...
Component integral component of membrane, membrane, ...
Function carbohydrate binding, G-protein coupled receptor activity, ...
External Resources: FuncBase
Expression
cDNA source data(12)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(12) cDNA(12)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000029552 (Evidence)
Ensembl Gene ModelENSMUSG00000037605 (Evidence)
Entrez Gene319387 (Evidence)
DFCITC1585311, TC1587570, TC1594342, TC1599467, TC1615404, TC1628252, TC1636726
DoTSDT.101235390, DT.40161797, DT.55140055, DT.91352358, DT.91573116, DT.94131824, DT.94133572, DT.97332154, DT.99848840
NIA Mouse Gene IndexU042649
Consensus CDS ProjectCCDS39122.1
International Mouse Knockout Project StatusLphn3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029552 VEGA Gene Model | MGI Sequence Detail 804996 C57BL/6J ±  kb
transcript OTTMUST00000073268 VEGA | MGI Sequence Detail 5178 Not Applicable 
polypeptide OTTMUSP00000037902 VEGA | MGI Sequence Detail 1580 Not Applicable 

For the selected sequences
All sequences(191) RefSeq(30) UniProt(19)
Polymorphisms SNPs within 2kb(4875 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000922 D-galactoside/L-rhamnose binding SUEL lectin domain
InterPro IPR022624 Domain of unknown function DUF3497
InterPro IPR001879 GPCR, family 2, extracellular hormone receptor domain
InterPro IPR003924 GPCR, family 2, latrophilin
InterPro IPR003334 GPCR, family 2, latrophilin, C-terminal
InterPro IPR015630 GPCR, family 2, latrophilin, type 3
InterPro IPR017981 GPCR, family 2-like
InterPro IPR000832 GPCR, family 2, secretin-like
InterPro IPR017983 GPCR, family 2, secretin-like, conserved site
InterPro IPR000203 GPS domain
InterPro IPR003112 Olfactomedin-like
Protein Ontology PR:000001235 latrophilin-3
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:185872 Wallis D, et al., Initial characterization of mice null for Lphn3, a gene implicated in ADHD and addiction. Brain Res. 2012 Jun 29;1463:85-92
All references(33)
Other
accession IDs
MGI:1921745

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory