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Adgrl3
Gene Detail
Symbol

Name
ID
Adgrl3
adhesion G protein-coupled receptor L3
MGI:2441950
Synonyms
5430402I23Rik, D130075K09Rik, LEC3, lectomedin 3, Lphn3, mKIAA0768
Feature Type
protein coding gene
Genetic Map
Chromosome 5
42.62 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr5:81020138-81825133 bp, + strand
From VEGA annotation of GRCm38

  804996 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:22878  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ADGRL3
Protein SuperFamily: alpha-latrotoxin receptor, calcium-independent type
Gene Tree: Adgrl3

Human
homologs
ADGRL3, adhesion G protein-coupled receptor L3
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 23284
neXtProt AC: NX_Q9HAR2

Human Synonyms: CIRL3, CL3, LEC3, LPHN3

Human Chr (Location): 4q13.1; chr4:61383124-62078335 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(3) Targeted(5)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a gene trap allele exhibit increased dopamine and serotonine levels in the dorsal striatum, hyperactivity, increased stereotypic behavior and enhanced hyperactivity in response to cocaine.
 
Interactions
Adgrl3 interacts with 552 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
cDNA source data(12)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA LPHN3 ZFIN adgrl3.1    NEW 
Molecular
reagents
All nucleic(12) cDNA(12)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000029552 (Evidence)
Ensembl Gene Model ENSMUSG00000037605 (Evidence)
Entrez Gene 319387 (Evidence)
DFCI TC1585311, TC1587570, TC1594342, TC1599467, TC1615404, TC1628252, TC1636726
DoTS DT.101235390, DT.40161797, DT.55140055, DT.91352358, DT.91573116, DT.94131824, DT.94133572, DT.97332154, DT.99848840
NIA Mouse Gene Index U042649
PDB 5AFB
Consensus CDS Project CCDS39122.1
International Mouse Phenotyping Consortium Status Adgrl3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029552 VEGA Gene Model | MGI Sequence Detail 804996 C57BL/6J ±  kb
transcript OTTMUST00000073268 VEGA | MGI Sequence Detail 5178 Not Applicable 
polypeptide OTTMUSP00000037902 VEGA | MGI Sequence Detail 1580 Not Applicable 

For the selected sequences
All sequences(195) RefSeq(48) UniProt(2)
Polymorphisms
SNPs within 2kb(4875 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000922 D-galactoside/L-rhamnose binding SUEL lectin domain
InterPro IPR001879 GPCR, family 2, extracellular hormone receptor domain
InterPro IPR003924 GPCR, family 2, latrophilin
InterPro IPR003334 GPCR, family 2, latrophilin, C-terminal
InterPro IPR017981 GPCR, family 2-like
InterPro IPR000832 GPCR, family 2, secretin-like
InterPro IPR017983 GPCR, family 2, secretin-like, conserved site
InterPro IPR000203 GPS motif
InterPro IPR015630 Latrophilin-3
InterPro IPR003112 Olfactomedin-like domain
Protein Ontology PR:000001235 latrophilin-3
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:218304 Hamann J, et al., International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G Protein-Coupled Receptors. Pharmacol Rev. 2015 Apr;67(2):338-67
All references(37)
Other
accession IDs
MGI:1921745

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory